一、 基本信息

高磊，男，1992年2月生，山西运城人，博士，副教授，硕士生导师。

2011-2015年就读于山西农业大学动物科学专业，获得农学学士学位；2015-2020年就读于中国农业大学动物遗传育种与繁殖专业（硕博连读），获得农学博士学位。2020年-至今，任职于西北农林科技大学动物科技学院。

一、社会兼职

《Journal of Pineal Research》审稿人

二、研究方向

主要从事哺乳动物配子与胚胎生物技术、动物生殖生理学研究

四、科研项目

1. MCU对猪卵母细胞减数分裂的影响机制，博士启动经费，主持

2. MCU对猪冷冻卵母细胞减数分裂中动粒-微管连接的影响机制，国家自然科学基金青年项目，主持

3.母猪妊娠后期关键调控技术研发，陕西省科协青年人才托举计划项目，主持

4.猪高产优质高效性状形成的调控网络及多基因互作机制，国家重点研发计划课题，参与

5.猪批次化生产精准繁殖调控技术升级与新产品研发，国家重点研发计划课题，参与

6.杂种优势评估与预测技术开发与应用，农业农村部保密项目，参与

五、学术成果

通讯作者文章

1. Sun H#, Guo Y#, Yu R, Wang J, Liu Y, Chen H, Pang W, Yang G, Chu G*, Gao L*. Ru360 protects against vitrification-induced oocyte meiotic defects by restoring mitochondrial function. Theriogenology. 2023 Jul 1;204:40-49.

2. Yaoyao Guo#, Haowei Sun#, Hui Chen, Gongshe Yang, Jialun Wang, Zhengjun Qi, Weijun Pang, Guiyan Chu, Lei Gao*,

Vitrification induces a focused spindle pole in mouse MI oocytes, Theriogenology, 2023 Nov;211:232-240.

3. Huang L, Zhang L, Shi S, Zhou X, Yuan H, Song X, Hu Y, Pang W, Yang G, Gao L*, Chu G*. Mitochondrial function and E2 synthesis are impaired following alteration of CLOCK gene expression in porcine ovarian granulosa cells. Theriogenology. 2023 May;202:51-60.

4. Sheng-jie SHI, Lu-tong ZHANG, Li-guang WANG, Huan YUAN, Hao-wei SUN, Mielie MADANIYATI, Chuan-jiang CAI, Wei-jun PANG, Lei GAO*, Gui-yan CHU*. MicroRNA-24-3p promotes proliferation and inhibits apoptosis of porcine granulosa cells by targeting P27, Journal of Integrative Agriculture, 2023, ISSN 2095-3119.

5. Yin L, Wang W, Pang W, Yang G, Gao L*, Chu G*. Insulin regulates gap junction intercellular communication in porcine granulosa cells through modulation of connexin43 protein expression. Theriogenology. 2023 Dec;212:172-180.

第一作者文章

6. Lei Gao#, Lutong Zhang#, Yuli Zhang, Mielie Madaniyati, Shengjie Shi, Liang Huang, Xiangrong Song, Weijun Pang, Guiyan Chu*, Gongshe Yang*. miR-10a-5p inhibits steroid hormone synthesis in porcine granulosa cells by targeting CREB1 and inhibiting cholesterol metabolism, Theriogenology, Volume 212, 2023, Pages 19-29

7. Lei Gao, Yunpeng Hou, Shenming Zeng, Junyou Li, Shien Zhu, Xiangwei Fu*. 2020.

The Error-Prone Kinetochore-Microtubule Attachments During Meiosis I in Vitrified Oocytes. Front Cell Dev Biol. 8: 621.

8. Lei Gao#, Gongxue Jia#, Zhengyuan Huang, Mingxing Yue, Chao Zhang, Shien Zhu, Yunpeng Hou, Xiangwei Fu*. 2020. Effect of Aging on Meiosis Progression, Developmental Competence and DNA Double-Strand Breaks in Mouse Oocytes. Pak J Zool. 52(4), 1463-1470.

9. Lei Gao#, Ming Du#, Qingrui Zhuan,Yuxi Luo , Junyou LI, Yunpeng Hou, Shenming Zeng, Shien Zhu, Xiangwei Fu*. 2019. Melatonin rescues the aneuploidy in mice vitrified oocytes by regulating mitochondrial heat product. Cryobiology, 89, 68-75.

10. Lei Gao#, Gongxue Jia#, Ai Li, Haojia Ma, Zhengyuan Huang, Zhu, Yunpeng Hou, Shien Zhu, Xiangwei Fu*. 2017. RNA-Seq transcriptome profiling of mouse oocytes after in vitro maturation and/or vitrification. Sci Rep, 7(1), 13245.

11. Jiao JH#, Gao L#, Yong WL, Kou ZY, Ren ZQ, Cai R, Chu GY, Pang WJ*. Resveratrol improves estrus disorder induced by bisphenol A through attenuating oxidative stress, autophagy, and apoptosis. J Biochem Mol Toxicol. 2022 Sep;36(9):e23120.

参与作者文章

12. Lihong Zhao, Tengfei Lu, Lei Gao, Xiangwei Fu, Shien Zhu, Yunpeng Hou*.

2017. Enriched endoplasmic reticulummitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice. J Anim Sci Biotechno, 8:62.

13. Zhengyuan Huang#, Jinghao Liu#, Lei Gao, Qingrui Zhuan, Yuxi Luo, Shien Zhu, Kaiyu Lei, Xiangwei Fu*. 2018.

The impacts of laser zona thinning on hatching and implantation of vitrified-warmed mouse embryos. Laser Med Sci. 34 (5): 939-945.

14. Qingrui Zhuan#, Haojia Ma#, Jing Chen#, Yuxi Luo, Yan Luo, Lei Gao, Yunpeng Hou, Shien Zhu, Xiangwei Fu*. 2020.

Cytoplasm lipids can be modulated through hormone-sensitive lipase and are related to mitochondrial function in porcine IVM oocytes. Reprod Fert Develop. 32 (7): 667-675.

15. 贾功雪，程柯仁，高磊，傅祥伟，朱士恩*.

2016. 玻璃化冷冻后小鼠卵母细胞及其早期胚胎中DNA甲基转移酶的表达模式. 中国畜牧杂志. 52 (09):18-21+92.

六、联系方式

通讯地址：陕西省咸阳市杨凌区西农路22号西北农林科技大学动物科技学院

邮编：712100

Email：gaolei5414@163.com