魏迎辉，男，1989年10月生，教授，博士生导师。入选国家“万人计划”青年拔尖人才、陕西省三秦英才引进计划、西北农林科技大学高层次人才支持计划。长期聚焦高效安全的基因编辑工具创新及具有优异性状的动物新种质创制等方向开展研究，以第一或通讯作者在Cell、Nature Chemical Biology、Nature Communications、Genome Biology等期刊发表多篇论文。主持农业生物育种重大项目-课题、国家自然科学基金生物育种专项、国家自然科学基金青年基金等多个项目。担任Journal of Genetics and Genomics、Agriculture Communications、Advanced Biotechnology等杂志的学术编辑或青年编委。

1. 教育经历

2013.09—2019.01 中国农业科学院，北京畜牧兽医研究所，动物遗传育种与繁殖，博士

2009.09—2013.07 河南科技学院，动物科技学院，动物科学，学士

2. 工作经历

2023.03—至今 西北农林科技大学，动物科技学院，教授

2021.10—2023.02 辉大（上海）生物科技有限公司，研究员/项目负责人

2019.08—2021.09 中国科学院，脑科学与智能技术卓越创新中心/神经科学研究所，博士后

3. 主要研究方向

（1）利用分子生物学、细胞生物学结合生物信息学，进行基因编辑工具的开发及优化工作。

（2）利用优化的基因编辑工具结合动物克隆技术，进行绵山羊育种新材料的创制，主要包括抗病育种及相关经济性状育种方向的新品系（种）培育。

4. 主持项目

（1）科技创新2030-重大项目，2023-2025，1083万，结题，课题主持。

（2）中组部国家万人计划青年拔尖人才项目，2026-2028，140万，在研，主持。

（3）国家自然科学基金生物育种青年专项，2025-2029，96万，在研，主持。

（4）国家自然科学基金青年项目，2024-2026，30万，在研，主持。

（5）西北农林科技大学引才经费，2023-2028，100万，在研，主持。

（6）陕西省创新创业人才项目，2024-2026，21万，在研，主持。

（7）新疆自治区重大科技专项，子课题，2024-2028，55万, 在研, 主持。

6. 代表性论文

(1) Yinghui Wei^#*, Pengfei Gao^#, Deng Pan^#, Guoling Li^#, Yufei Chen^#, Shangpu Li, Henan Jiang, Yang Yue, Zhenmin Wu, Zujiang Liu, Min Zhou, Yulin Chen, Kun Xu^*, Zhaowei Wu^*, Xiaolong Wang^*. Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals. Nature Chemical Biology, 2026, 22 (1): 48-57. (IF=13.7, Co-first author, Co-corresponding author)

(2) Shangpu Li^#, Kun Xu^#, Guoling Li^#, Henan Jiang^#, Zhenmin Wu^#, Pengfei Gao^#, Yang Yue, Yufei Chen, Zujiang Liu, Bingqian Zhou, Min Zhou, Yulin Chen, Xu Liu^*, Xiaolong Wang^*, Zhaowei Wu^*, Yinghui Wei^*. Engineering the MmeFz2-ωRNA system for efficient genome editing through an integrated computational-experimental framework. Nature Communications, 2026, 17 (1): 1867. (IF=15.7, Co-corresponding author)

(3) Xu Yan^#, Mingyue Chen^#, Shunkai Yang^#, Yuyang Guo^#, Yichao Dai^#, Yutong Chen, Haijiang Zhong, Taisen Ma, Dingrui Zha, Yutao He, Baiyu Li, Xinyu Jia, Long Guo^*, Jianhong Hu^*, Yinghui Wei^*, Xiaoxu Chen^*. Mitochondrial genome editing tools: prospects in animal breeding. Journal of Genetics and Genomics, 2026, S1673-8527(26)00062-7. Online ahead of print. (IF=7.1, Co-corresponding author)

(4) Yinghui Wei^#*, Xi Cao^#, Shuhong Huang^#, Yang Yue^#, Muhua Luo^#, Zujiang Liu^#, Bo Liu, Qijing Zhang, Yangsheng Wu, Liqin Wang, Jiapeng Lin, Yulin Chen, Wenxin Zheng, Weiwei Wu^*, Kun Xu^*, Xiaolong Wang^*. Efficient glycosylase-mediated base editing with minimal off-target effects in mammalian embryos. Genome Biology, 2025, 26 (1): 360. (IF=9.4, Co-first author, Co-corresponding author)

(5) Nei Li, Bowen Wu, Yudian Xiao, Yijia Hao, Fan Wu, Yinghui Wei^*, Ying Xu^*, Xuexiang Han^*. Tools and delivery technologies for mitochondrial gene editing, Cell Biomaterials, 2025, 100254. (Co-corresponding author)

(6) Zheng Li^#, Wei Zhao^#, Shaokang Li^#, Xi Luo^#, Yinghui Wei^#, Yuanyan Zhang, Zhengyan Ye, Shangpu Li, Ming Wang, Junjie Tan^*, Ralph Bock. Engineering of high-precision C-to-G base editors with expanded site selectivity and target compatibility. Nucleic Acids Research, 2025, 53 (15): gkaf717. (IF=13.1, Co-first author)

(7) Jia Huang^#, Bingbing He^#, Xiali Yang^#, Xin Long^#, Yinghui Wei^#, Leijie Li^#, Min Tang, Yanxia Gao, Yuan Fang, Wenqin Ying, Zikang Wang, Chao Li, Yingsi Zhou, Shuaishuai Li, Linyu Shi, Seungwon Choi^*, Haibo Zhou^*, Fan Guo^*, Hui Yang^*, Jun Wu^*. Generation of rat forebrain tissues in mice. Cell, 2024, 187 (9): 2129-2142.e17. (IF=64.5, Co-first author)

(8) Yinghui Wei^#*, Ming Jin^#, Shuhong Huang^#, Fangyao Yao^#, Ningxin Ren, Kun Xu, Shangpu Li, Pengfei Gao, Yingsi Zhou, Yulin Chen, Hui Yang, Wen Li^*, Chunlong Xu^*, Meiling Zhang^*, Xiaolong Wang^*. Enhanced C-To-T and A-To-G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED. Advanced Science, 2024, 11 (3): e2304113. (IF=15.1, Co-first author, Co-corresponding author)

(9) Yinghui Wei^#, Meiling Zhang^#*, Jing Hu^#, Yingsi Zhou^#, Mingxing Xue^#, Jianhang Yin, Yuanhua Liu, Hu Feng, Ling Zhou, Zhifang Li, Dongshuang Wang, Zhiguo Zhang, Yin Zhou, Hongbin Liu, Ning Yao, Erwei Zuo, Jiazhi Hu, Yanzhi Du^*, Wen Li^*, Chunlong Xu^*, Hui Yang^*. Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor. Protein & Cell, 2023, 14: 1-17. (IF=21.1, Co-first author)

(10) Huawei Tong^#*, Nana Liu^#, Yinghui Wei^#, Yingsi Zhou^#, Yun Li^#, Danni Wu^#, Ming Jin, Shuna Cui, Hengbin Li, Guoling Li, Jingxing Zhou, Yuan Yuan, Hainan Zhang, Linyu Shi, Xuan Yao, Hui Yang^*. Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase. National Science Review, 2023, 10 (8): nwad143. (IF=20.6, Co-first author)

(11) Yinghui Wei^#, Zhifang Li^#, Kui Xu^#, Hu Feng^#, Long Xie^#, Di Li, Zhenrui Zuo, Meiling Zhang^*, Chunlong Xu^*, Hui Yang^*, Erwei Zuo^*. Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos. Cell Discovery, 2022, 8 (1): 27. (IF=33.5, Co-first author)

(12) Yinghui Wei^#, Chunlong Xu^#, Hu Feng^#, Kui Xu^#, Zhifang Li^#, Jing Hu, Ling Zhou, Yu Wei, Zhenrui Zuo, Erwei Zuo, Wen Li^*, Hui Yang^*, Meiling Zhang^*. Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE. Cell Discovery, 2022, 8 (1): 7. (IF=33.5, Co-first author)

(13) Yinghui Wei^#, Qian Gao^#, Pengxia Niu^#, Kui Xu, Yiqing Qiu, Yanqing Hu, Shasha Liu, Xue Zhang, Miaoying Yu, Zhiguo Liu, Bingyuan Wang, Yulian Mu^*, Kui Li^*. Integrative Proteomic and Phosphoproteomic Profiling of Testis from Wip1 Phosphatase-Knockout Mice: Insights into Mechanisms of Reduced Fertility. Molecular & Cellular Proteomics, 2019, 18 (2): 216-230. (IF=4.9, Co-first author)

(14) Yinghui Wei, Junhua Fan, Lin Li, Zhiguo Liu^*, Kui Li. Pretreating porcine sperm with lipase enhances developmental competence of embryos produced by intracytoplasmic sperm injection. Zygote, 2016, 24 (4): 594-602.

7. 联系方式

通讯地址：陕西省咸阳市杨凌区西农路22号西北农林科技大学动物科技学院

邮编：712100

E-mail：yinghuiwei@nwafu.edu.cn; yinghuiwei1019@126.com