1．基本信息

孙超，男，教授，博导，教育部新世纪优秀人才，宝钢优秀教师，国家自然科学基金委学科评审组会评专家。1993年在原西北农业大学本科毕业并留校任教，2001年在西北农林科技大学获博士学位，2002年晋升副教授并开始招收硕士生，2006年破格聘任为博导，2008年晋升教授，2009年在美国宾州州立大学做2年博士后，2004年-2007年任学校实验室管理处副处长，2013年-2021年任动物科技学院副院长。主编教材8本，获省级教学成果特等奖、一等奖各1项；主持国家973计划课题、国家转基因重大专项、十四五重点研发计划子课题各1项、国家自然基金面上项目5项等科研项目，公开发表学术论文130余篇，其中中科院1区论文16篇，获省科学技术二等奖3项、三等奖1项。

2.研究方向

动物脂质代谢的可塑性调控及其遗传机理、动物肉脂性状形成的分子遗传调控机理、肥胖症与糖尿病的发生机理及其防治。

3.开设课程

《动物生化》 《分子生物学》 《高级动物生物化学》 《现代动物生物化学》 《动物生物技术》等课程。

4.学术成果

发表的主要学术论文：

1.Wei, D., Tian, X., Zhu, L., Wang, H., & Sun, C. (2023). USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1. Cell Death & Disease, 14(8), 566.

2.Yang, H., Li, C., Che, M., Li, Y., Feng, R., & Sun, C. (2023). Gut microbiota mediates the anti-obesity effect of intermittent fasting by inhibiting intestinal lipid absorption. The Journal of Nutritional Biochemistry, 116, 109318.

3.Li, Y., Liang, J., Tian, X., Chen, Q., Zhu, L., Wang, H., ... & Sun, C. (2023). Intermittent fasting promotes adipocyte mitochondrial fusion through Sirt3-mediated deacetylation of Mdh2. British Journal of Nutrition, 1-14.

4.Li, C., Chen, Q., Liu, Y., Sun, Z., Shen, Z., Li, S., ... & Sun, C. (2023). Methionine enkephalin promotes white fat browning through cAMP/PKA pathway. Life Sciences, 312, 121189.

5.Wei, D., Li, Y., Che, M., Li, C., Wu, Q., & Sun, C. (2022). Melatonin relieves hepatic lipid dysmetabolism caused by aging via modifying the secondary bile acid pattern of gut microbes. Cellular and Molecular Life Sciences, 79(10), 527.

6.Pan, M., Sun, Q., Li, C., Tai, R., Shi, X. E., & Sun, C. (2022). Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2/STAT3 signaling pathway in mice. Biochemistry and Cell Biology, 100(4), 325-337.

7.Liu, Y., Li, Y., Liang, J., Sun, Z., Wu, Q., Liu, Y., & Sun, C. (2022). Leptin: an entry point for the treatment of peripheral tissue fibrosis and related diseases. International Immunopharmacology, 106, 108608.

8.Chen, Y., Che, M., Li, C., Li, Y., Zhang, T., Li, X., & Sun, C. (2022). PP1A prevents ROS‐induced pyroptosis by inhibiting MAPK/caspase‐3 in mouse adipose tissue. The FEBS Journal, 289(13), 3839-3853.

9.Wu, Q., Yang, H., Tai, R., Li, C., Xia, T., Liu, Y., & Sun, C. (2022). Lnc‐hipk1 inhibits mouse adipocyte apoptosis as a sponge of miR‐497. BioFactors, 48(1), 135-147.

10.Yang, H., Li, C., Li, Y., Tai, R., & Sun, C. (2021). Adipose-derived stem cells and obesity: The spear and shield relationship. Genes & Diseases.

11.Rong, B., Wu, Q., Reiter, R. J., & Sun, C. (2021). The mechanism of oral melatonin ameliorates intestinal and adipose lipid dysmetabolism through reducing Escherichia Coli-derived lipopolysaccharide. Cellular and Molecular Gastroenterology and Hepatology, 12(5), 1643-1667.

12.Rong, B., Wu, Q., Saeed, M., & Sun, C. (2021). Gut microbiota—A positive contributor in the process of intermittent fasting-mediated obesity control. Animal Nutrition, 7(4), 1283-1295.

13.Shen, Z., Liu, P., Sun, Q., Li, Y., Acharya, R., Li, X., & Sun, C. (2021). FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes. Apoptosis, 26(7-8), 474-487.

14.Liu, Y., Yang, H., Liu, X., Gu, H., Li, Y., & Sun, C. (2021). Protein acetylation: a novel modus of obesity regulation. Journal of Molecular Medicine, 99(9), 1221-1235.

15.Gu, H., Yang, K., Shen, Z., Jia, K., Liu, P., Pan, M., & Sun, C. (2021). ER stress—induced adipocytes secrete-aldo-keto reductase 1B7—containing exosomes that cause nonalcoholic steatohepatitis in mice. Free Radical Biology and Medicine, 163, 220-233.

16.Yang, H., Chen, L., Sun, Q., Yao, F., Muhammad, S., & Sun, C. (2021). The role of HDAC11 in obesity‐related metabolic disorders: A critical review. Journal of Cellular Physiology, 236(8), 5582-5591.

17.Zhang, T., Chen, Y., Cai, J., Pan, M., Sun, Q., Zhang, J., & Sun, C. (2020). SOCS2 inhibits mitochondrial fatty acid oxidation via suppressing LepR/JAK2/AMPK signaling pathway in mouse adipocytes. Oxidative Medicine and Cellular Longevity, 2020.

18.Xia, T., Shen, Z., Cai, J., Pan, M., & Sun, C. (2020). ColXV aggravates adipocyte apoptosis by facilitating abnormal extracellular matrix remodeling in mice. International Journal of Molecular Sciences, 21(3), 959.

19.Yang, K., Cai, J., Pan, M., Sun, Q., & Sun, C. (2020). Mark4 inhibited the browning of white adipose tissue by promoting adipocytes autophagy in mice. International Journal of Molecular Sciences, 21(8), 2752.

20.Yang, H., Yang, K., Gu, H., & Sun, C. (2020). Dynamic post‐translational modifications in obesity. Journal of Cellular and Molecular Medicine, 24(3), 2384.

21.Saeed, M., Khan, M. S., Kamboh, A. A., Alagawany, M., Khafaga, A. F., Noreldin, A. E., ... & Chao, S. (2020). L-theanine: an astounding sui generis amino acid in poultry nutrition. Poultry science, 99(11), 5625-5636.

22.Saeed, M., Naveed, M., BiBi, J., Ali Kamboh, A., Phil, L., & Chao, S. (2019). Potential nutraceutical and food additive properties and risks of coffee: A comprehensive overview. Critical reviews in food science and nutrition, 59(20), 3293-3319.

23.Rong, B., Feng, R., Liu, C., Wu, Q., & Sun, C. (2019). Reduced delivery of epididymal adipocyte‐derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice. Journal of Pineal Research, 66(4), e12561.

24.Zhang, Z., Zhang, T., Feng, R., Huang, H., Xia, T., & Sun, C. (2019). circARF3 alleviates mitophagy-mediated inflammation by targeting miR-103/TRAF3 in mouse adipose tissue. Molecular Therapy-Nucleic Acids, 14, 192-203.

25.Bohan, R., Tianyu, X., Tiantian, Z., Ruonan, F., Hongtao, H., Qiong, W., & Chao, S. (2019). Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism. The journal of nutritional biochemistry, 64, 206-217.

26.Zhang, T., Zhang, Z., Xia, T., Liu, C., & Sun, C. (2019). circNrxn2 promoted WAT browning via sponging miR-103 to relieve its inhibition of FGF10 in HFD mice. Molecular Therapy-Nucleic Acids, 17, 551-562.

27.Cao, W., Zhang, T., Feng, R., Xia, T., Huang, H., Liu, C., & Sun, C. (2019). Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue. Journal of cellular and molecular medicine, 23(10), 7029-7042.

28.Saeed, M., Yatao, X., Tiantian, Z., Qian, R., & Chao, S. (2019). 16S ribosomal RNA sequencing reveals a modulation of intestinal microbiome and immune response by dietary L-theanine supplementation in broiler chickens. Poultry science, 98(2), 842-854.

29.Song, Z., Wang, Y., Zhang, F., Yao, F., & Sun, C. (2019). Calcium signaling pathways: key pathways in the regulation of obesity. International Journal of Molecular Sciences, 20(11), 2768.

30.Liu, Z., Gan, L., Zhang, T., Ren, Q., & Sun, C. (2018). Melatonin alleviates adipose inflammation through elevating α‐ketoglutarate and diverting adipose‐derived exosomes to macrophages in mice. Journal of pineal research, 64(1), e12455.

31.Gan, L., Liu, Z., & Sun, C. (2018). Obesity linking to hepatocellular carcinoma: a global view. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1869(2), 97-102.

32.Cao, W., Huang, H., Xia, T., Liu, C., Muhammad, S., & Sun, C. (2018). Homeobox a5 promotes white adipose tissue browning through inhibition of the tenascin C/toll-like receptor 4/nuclear factor kappa B inflammatory signaling in mice. Frontiers in Immunology, 9, 647.

33.Zhang, Z., Wu, S., Muhammad, S., Ren, Q., & Sun, C. (2018). miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/β-catenin/ATF6 pathway in preadipocytes. Journal of lipid research, 59(5), 843-853.

34.Saeed, M., Yatao, X., Hassan, F. U., Arain, M. A., Abd El-Hack, M. E., Noreldin, A. E., & Sun, C. (2018). Influence of graded levels of l-theanine dietary supplementation on growth performance, carcass traits, meat quality, organs histomorphometry, blood chemistry and immune response of broiler chickens. International Journal of Molecular Sciences, 19(2), 462.

35.Gan, L., Liu, Z., Feng, F., Wu, T., Luo, D., Hu, C., & Sun, C. (2018). Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice. International Journal of Obesity, 42(2), 252-259.

36.Li, M., Beauchemin, H., Popovic, N., Peterson, A., d’Hennezel, E., Piccirillo, C. A., ... & Polychronakos, C. (2017). The common, autoimmunity-predisposing 620Arg> Trp variant of PTPN22 modulates macrophage function and morphology. Journal of autoimmunity, 79, 74-83.

37.Liu, Z., Gan, L., Xu, Y., Luo, D., Ren, Q., Wu, S., & Sun, C. (2017). Melatonin alleviates inflammasome‐induced pyroptosis through inhibiting NF‐κB/GSDMD signal in mice adipose tissue. Journal of Pineal Research, 63(1), e12414.

38.Liu, Z., Gan, L., Luo, D., & Sun, C. (2017). Melatonin promotes circadian rhythm‐induced proliferation through C lock/histone deacetylase 3/c‐M yc interaction in mouse adipose tissue. Journal of pineal research, 62(4), e12383.

39.Saeed, M., Naveed, M., Arif, M., Kakar, M. U., Manzoor, R., Abd El-Hack, M. E., ... & Sun, C. (2017). Green tea (Camellia sinensis) and l-theanine: Medicinal values and beneficial applications in humans—A comprehensive review. Biomedicine & Pharmacotherapy, 95, 1260-1275.

40.Liu, Z., Gan, L., Wu, T., Feng, F., Luo, D., Gu, H., ... & Sun, C. (2016). Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell death & disease, 7(11), e2487-e2487.

主持的科研项目：

1. 猪高产优质高效性状形成的调控网络及多基因互作机制，“十四五”国家重点研发计划，2021.01-2026.12，120万。（子课题负责人）

2. 复合微生态制剂替代抗生素添加剂的系列产品研发和应用，青海省重点研发与转化计划，2022.01-2025.12，60万。

3. 生猪低碳健康养殖与养分高效利用技术研究与实践，陕西省2021年重点研发计划，2021.01-2022.12，10万。

4. Hoxa5通过脂肪组织固有淋巴细胞促进猪白色脂肪棕色化的分子机制，国家自然科学基金，2019.01-2021.12，49万元。

5. 猪肌内脂肪形成分子调控与新品种选育创新团队，陕西省重点科技创新团队建设项目（2017KCT-24），2017/01-2019/12，100万

6. Leptin及相关因子调控猪脂肪发育的分子机制，973计划项目（2015CB943102），2016/01-2019/12，450万

7. 胶原XV通过“Ca2+-内质网”轴调节猪白色脂肪棕色化的作用机制，国家自然科学基金（31572365），2016/01-2019/12，76.8万

8. 猪脂肪沉积关键基因bambi的克隆及功能验证,农业部转基因重大专项，2014/01-2016/12，170万元

9. αMSH通过PKA和ERK信号通路调节猪脂肪沉积和Leptin及Foxc2分泌的分子机制，国家自然科学基金（31172185），2014/01-2016/12，58.0万

10. SOCS-2在GH信号通路调控猪脂代谢中的分子机理及与SOCS-3的关系，国家自然科学基金，2009.01-2011.12，38万元。

荣获的奖励：

科研奖励

1. Leptin调控脂肪细胞发育与代谢的分子机制，吴常信动物遗传育种科技成果奖， 2015，排名1；

2. 西北五省区重要地方畜禽遗传资源研究，陕西省人民政府，陕西省科学技术奖，二等，2012，排名3；

3. 猪脂肪沉积及其调控机制研究，陕西省人民政府，陕西省科学技术奖，三等，2016，排名4；

个人奖励

1. 陕西省教学成果特等奖，陕西省人民政府，2020，排名2；

2. 陕西省教学成果一等奖，陕西省人民政府，2020，排名8；

3. 陕西省一流课程（负责人），陕西省教育厅，2019，排名1；

4. 全国宝钢优秀教师奖，宝钢教育基金会，2017，排名1；

5. 陕西省优秀教学团队（负责人），陕西省教育厅，2015，排名1；

6. 入选教育部“新世纪优秀人才”，教育部，2007，排名1

5.联系方式

通讯地址：陕西杨凌西农路22号 西北农林科技大学动物科技学院

邮编：712100

Email: sunchao2775@163.com