一、基本信息
陈宁博,男,1987年生,博士,副教授,博士生导师,2019年获西北农林科技大学动物遗传育种与繁殖专业博士学位,同年留校为副教授,陕西省青年科技新星。兼任中国畜牧兽医学会畜禽标记分会理事,陕西省遗传学会常务理事。致力于中国地方黄牛的起源与迁徙历史和适应性进化的分子机制研究;从线粒体DNA、Y-DNA到全基因组分析,从生物信息学大数据挖掘到细胞功能验证,再到史前牛科动物(古DNA)的时空研究方法,探讨东亚地区黄牛的群体历史及其环境适应的分子机制,从遗传学、考古学等交叉科学的视角,揭示东亚家牛复杂的遗传背景、群体历史及其与环境适应的关系。现兼任BMC Biology、BMC Genomics、Genomics Proteomics Bioinformatics (GPB), Animal Research and One Health (AROH);Journal of Genetics and Genomics (JGG)和Journal of Integrative Agriculture (JIA)、中国农业科学等杂志编委及青年编委。应邀为PNAS,Genome Biology,Science China Life Sciences,iScience,BMC Genomics,Journal of Animal Breeding and Genetics,Animal Genetics,Genetic Selection Evolution,BMC Ecology and Evolution 等杂志审稿。
二、联系方式
Email: ningbochen@nwafu.edu.cn; ningboch@126.com
三、招生与研究方向
欢迎有意从事牛遗传资源研究和牛基因组学分析等相关研究的学生报考硕、博士研究生。
[1] 利用古代、现代牛族动物基因组解析中国地方黄牛的群体演化规律及适应性渗入;
[2] 利用 de novo 组装、二代、三代测序技术挖掘中国地方黄牛基因组关键遗传变异;
[3] 利用转录组、调控组等多组学数据研究中国地方黄牛抗逆性状的遗传机制;
[4] 牛基因组遗传变异和调控网络数据库构建。
四、主持科研项目
[1]国家自然科学基金-生物育种专项,2024-2028;100万;
[2]国家自然科学基金-青年项目,2022-2024,30万;
[3]陕西省青年科技新星项目,2022-2023;10万;
[4]高端外国专家引进计划,2022-2023,37万;
[5]中国博士后科学基金面上项目-特别资助,2021-2022,18万;
[6]陕西省自然科学基金-一般项目,2021-2022,3万;
[7]中国博士后科学基金-面上项目,2020-2022,8万;
五、参与科研项目
[1]国家自然基金面上项目,2019-2022,59万;
[2]国家重点研发计划-青年科学家项目,2022-2025年,400万。
[3]西藏自治区重点研发计划,2023-2025,200万。
六、奖励
[1] 西北农林科技大学校级优秀博士论文,2019年;
[2] 中国畜牧兽医学会奖(优秀论文奖),2020年;
[3]
吴常信动物遗传育种科技成果奖,2021年;
[4] 陕西省优秀博士论文,2021年;
[5] 陕西省青年科技新星,2022年;
[6] ISAG Bursary Winner,2023年。
七、代表性论文
围绕中国黄牛的起源进化和遗传资源研究,利用古代、现代基因组解析了中国黄牛的群体演化规律和适应性进化。以第一和通讯作者在Science Advances、Genome Biology、PNAS、Nature Communications、Science Bulletin等期刊发表科研论文16篇。其中影响因子>10的期刊8 篇,累计影响因子127。
[1]Shungang Chen *, Lele Ren, Yu Gao, Guanghui Dong, Guilian Sheng, Jianlin Han, Xinyi Liu, Ningbo Chen*, Fahu Chen. (2024) Evidence of hybridization of cattle and aurochs on the Tibetan Plateau ~3750 years ago. Science Bulletin【提供青藏高原早期东亚原牛和家养黄牛杂交证据】【IF=18.8】
[2]Yang Lyu#, Fuwen Wang#, Haijian Cheng#, Jing Han#, Ruihua Dang#, Xiaoting Xia#, Hui Wang, Jincheng Zhong, Johannes A. Lenstra, Hucai Zhang, Jianlin Han, David MacHugh, Ivica Medugorac, Maulik Upadhyay, Alexander S Leonard, He Ding, Xiaorui Yang, Mingshan Wang, Suolang Quji, Basang Zhuzha, Pubu Quzhenp, Silang Wangmu, Nima Cangjue, Da Wa, Weidong Ma, Jianyong Liu, Jicai Zhang, Bizhi Huang, Xingshan Qi , Fuqiang Li , Yongzhen Huang, Yun Ma , Yu Wang, Yuanpeng Gao*, Wenfa Lu*, Chuzhao Lei*, Ningbo Chen*. (2024). Recent selection and adaptive introgression facilitated high-altitude adaptation of Qinghai-Tibetan Plateau cattle Science Bulletinhttps://doi.org/10.1016/j.scib.2024.05.030【从全基因组水平深度解析了青藏高原黄牛的起源和高原适应性,发现近期选择和牦牛的基因组渗入共同促进黄牛适应高海拔环境】【IF=18.8】
[3]Ningbo Chen#, Xiaoting Xia#, Quratulain Hanif#, Fengwei Zhang#, Ruihua Dang#, Bizhi Huang#, Yang Lyu, Xiaoyu Luo, Hucai Zhang, Shikang Wang, Fuwen Wang, Jialei Chen, Xiwen Guan, Yangkai Liu, Shuang Li, Liangliang Jin, Pengfei Wang, Luyang Sun, Haijian Cheng, Jicai Zhang, Jianyong Liu, Kaixing Qu, Yanhong Cao, Junli Sun, Yuying Liao, Zhengzhong Xiao, Ming Cai,Lan Mu, AMAM Zonaed Siddiki, Muhammad Asif, Shahid Mansoor, Masroor Ellahi Babar, Tanveer Hussain, Gamamada Liyanage Lalanie Pradeepa Silva, Neena Amatya Gorkhali, Endashaw Terefe,, Gurja Belay, Abdulfatai Tijjani, Tsadkan Zegeye, Mebrate Genet Gebre, Yun Ma, Yu Wang, Yongzhen Huang, Xianyong Lan, Hong Chen, Nicola Rambaldi Migliore, Giulia Colombo, Ornella Semino, Alessandro Achilli, Mikkel-Holger S Sinding, Johannes A Lenstra, Olivier Hanotte*, Jianlin Han*, Yu Jiang*, Chuzhao Lei*. (2023) Global genetic diversity, introgression and evolutionary adaptation of indicine cattle revealed by whole genome sequencing. Nature Communications. 14, 7803.【利用全球57个主要瘤牛品种354个样品,从全基因组水平深度解析了全世界瘤牛常染色体、父系和母系遗传特征,系统阐述了全球瘤牛的起源迁徙扩散路线及其对不同环境的适应性进化】【IF=14.7】
[4]Ningbo Chen#, Zhengwei Zhang#, Jiawen Ho#, Jialei Chen#, Xuan Gao, Li Tang, Shargan Wangdue, Xiaoming Zhang, Mikkel-Holger S Sinding, Xuexue Liu, Jianlin Han, Hongliang Lü*, Chuzhao Lei*,
Fiona Marshall* and Xinyi Liu*. (2023) Evidence for early domestic yak, taurine cattle, and their hybrids on the Tibetan Plateau. Science Advances. 9, eadi6857.【综合运用动物考古学和古DNA分析技术,发现西藏邦嘎遗址鲜明同时饲养、利用了牦牛与黄牛。提供了邦嘎黄牛和牦牛发生杂交的遗传学证据】【IF=11.7】
[5]Xiaoting Xia, Fengwei Zhang, Shuang Li, Xiaoyu Luo, Lixin Peng, Zheng Dong, Hubert Pausch, Alexander S. Leonard, Danang Crysnanto, Shikang Wang, Bin Tong, Johannes A. Lenstra, Jianlin Han, Fuyong Li, Tieshan Xu, Lihong Gu, Liangliang Jin, Ruihua Dang, Yongzhen Huang, Xianyong Lan, Gang Ren, Yu Wang, Yuanpeng Gao, Zhijie Ma, Haijian Cheng, Yun Ma, Hong Chen, Weijun Pang*, Chuzhao Lei*, Ningbo Chen* (2023) Structural variation and introgression from wild populations in East Asian cattle genomes confer adaptation to local environment. Genome Biology. 24, 211.【Featured article, 组装了东亚瘤牛和欧亚普通牛代表性品种的基因组,利用三代、二代群体数据,鉴定两个群体的基因组结构变异特征及其来源,利用多组学数据和分子生物学方法鉴定两个群体环境适应性相关SV,并进一步验证结核病相关基因 SPN 的作用】【IF=10.1】
[6]Chen Ningbo#; Ren Lele#; Du Linyao#; Hou Jiawen#; Mullin Victoria E; Wu Duo; Zhao Xueye; Li Chunmei; Huang Jiahui; Qi Xuebin; Capodiferro Marco Rosario; Achilli Alessandro; Lei Chuzhao; Chen Fahu; Su Bing*; Dong Guanghui*; Zhang Xiaoming*. (2020) Ancient genomes reveal tropical bovid species in the Tibetan Plateau contributed to the prevalence of hunting game until the late Neolithic. Proceedings of the National Academy of Sciences, 2020, 117(45): 28150-28159. 【当期亮点论文,古代基因组证据揭示热带牛科动物在青藏高原东北部的史前分布及其对中国地方黄牛的影响) (作为交叉学科合作研究并取得重要发现的范例,该成果发表后受到了多个领域和公众的广泛关注,相继被CCTV新闻频道(科技新闻)、中科院官网、新华社国际网、美国科学促进会(AAAS)、科普中国、科学网、中新网和科技日报等20多个主流媒体和宣传平台报道】【IF=11.205】
[7]Chen Ningbo#; Cai Yudong#; Chen Qiuming#; Li Ran#; Wang Kun#; Huang Yongzhen#; Hu Songmei; Huang Shisheng; Zhang Hucai; Zheng Zhuqing; Song Weining; Ma Zhijie; Ma Yun; Dang Ruihua; Zhang Zijing; Xu Lei; Jia Yutang; Liu Shanzhai; Yue Xiangpeng; Deng Weidong; Zhang Xiaoming; Sun Zhouyong; Lan Xianyong; Han Jianlin; Chen Hong; Bradley Daniel G; Jiang Yu*; Lei Chuzhao*. (2018) Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia. Nature Communications 9. 【Featured Article 解析了中国地方家牛的群体演化规律和适应性渗入位点,中国地方黄牛拥有三个祖先血统,东亚瘤牛和东亚普通牛分别受到爪哇牛和牦牛的适应性渗入。】【IF=14.7】
[8]Chen, Ningbo#; Fu, Weiwei#; Zhao, Jianbang; Shen, Jiafei; Chen, Qiuming; Zheng, Zhuqing; Chen, Hong; Sonstegard, Tad S.; Lei, Chuzhao; Jiang, Yu*. (2020) BGVD: Integrated Web-database for Bovine Sequencing Variations and Selective Signatures. Genomics, Proteomics & Bioinformatics. 2020, 18(2): 186-193.【构建全世界家牛基因组遗传变异数据库】【IF=11.5】
[9]Ningbo Chen, Artem Nedoluzhko. (2023) Ancient DNA: the past for the future. BMC Genomics 2023 24:309.【IF=4.4】
[10]Yang Lyu, Yaxuan Ren, Kaixing Qu, Suolang Quji, Basang Zhuzha, Chuzhao Lei*, Ningbo Chen* (2023) Local ancestry and selection in admixed Sanjiang cattle. Stress Biology. 3:30.
[11]Fengwei Zhang#, Chong Wang#, Haiyue Xu#, Xiaoting Xia, Xiaoyu Luo, Kaihui Li, Jianlin Han, Chuzhao Lei*, Ningbo Chen*, Xiangpeng Yue*. (2023) Genomic analysis reveals a KIT-related chromosomal translocation associated with the white coat phenotype in yak. Journal of Animal Breeding and Genetics. 140(3):330-342. 【利用GWAS解析了白牦牛白色与KIT基因易位相关,并发现该易位基因来源于普通牛的渗入】【IF=3.271】
[12]Xiaoting Xia, Kaixing Qu, Yan Wang, Mikkel‑Holger S. Sinding, Fuwen Wang, Quratulain Hanif, Zulfqar Ahmed, Johannes A. Lenstra, Jianlin Han, Chuzhao Lei* and Ningbo Chen*. (2023) Global dispersal and adaptive evolution of domestic cattle: a genomic perspective. Stress Biology. 3:8. 【从基因组角度综述全世界家牛的扩散规律和适应性进化】
[13]陈宁博,雷初朝.从DNA角度认识中国黄牛的起源和利用历史.第四纪研究,2022,42(1):92-100.
[14]Yuqing Han#, Lulan Zeng#, Shuang Li, Gaoxiang Yuan, Ying Liu, Xuhong Ding, Kaixing Qu, Fuqiang Li, Jicai Zhang, Chuzhao Le, Bizhi Huang*, Ningbo Chen*. (2021) T2R12 gene variation in Chinese native cattle owing to banteng introgression. Animal Genetics,52(4):565-566. 【IF=3.169】
[15]Xiao-Ting Xia, Alessandro Achilli, Johannes A. Lenstra, Bin Tong, Yun Ma, Yong-Zhen Huang, Jian-Lin Han, Zhou-Yong Sun, Hong Chen, Chu-Zhao Lei1, Song-Mei Hu*, Ning-Bo Chen*. (2021) Mitochondrial genomes from modern and ancient Turano-Mongolian cattle reveal an ancient diversity of taurine maternal lineages in East Asia. Heredity, 126(6):100-1008.【利用古代和现代线粒体基因组解析东亚普通牛特异的线粒体单倍型T3055, T3119和T4】【IF=3.821】
[16]Chen Ningbo#; Huang Jieping#; Zulfiqar Abbasi; Li Ran; Xi Yulian; Zhang Mingming; Dang Ruihua; Lan Xianyong; Chen Hong; Ma Yun; Lei Chuzhao*. (2018) Population structure and ancestry of Qinchuan cattle. Animal Genetics 49, 246-8. 【IF=1.841】
八、发明专利
[1] 陈宁博;雷初朝;许星龙;夏小婷;党瑞华;黄永震;蓝贤勇;陈宏.一种利用Y染色体单核苷酸遗传标记鉴定瘤牛公牛来源的方法(授权专利号:ZL202111277432.3)
[2] 陈宁博;雷初朝;陈嘉磊;张俸伟;宋仁德;晓虎;贺顺忠;白玛求措;宋维茹;李淑玲;索南代青;拉巴永措;巴阳.一种利用MC1R基因单核苷酸遗传标记鉴定金丝牦牛品种的方法(授权专利号:ZL202111165152.3)
九、参加的国内国际大会
[1]Recent selection and introgression facilitated high-altitude adaptation in cattle, PAG Asia (Shenzhen, 2024);
[2]Structural Variations in East Asian Cattle, PAG Asia (Shenzhen, 2024);
[3]Structural Variation and Wild Introgression in East Asian Cattle, PAG Australia (Perth, 2023);
[4]History and unique evolutionary adaptation of indicine cattle, PAG Australia (Perth, 2023);
[5]全世界瘤牛基因组遗传变异与环境适应性研究,第二十二次全国动物遗传育种学术讨论会 (太原,2023);
[6]全世界瘤牛的起源进化和适应性研究,第十八次全国畜禽遗传标记学术研讨会 (大会报告,南京,2023);
[7]中国地方黄牛的群体演化规律和适应性研究,中国畜牧兽医学会家畜生态学分会2023年学术研讨会(大会报告,扬州,2023);
[8]青藏高原黄牛的起源和环境适应性研究,第六届中国肉牛选育改良与产业发展国际研讨会(大会报告,杨凌,2023);
[9]中国地方黄牛的群体演化规律和适应性研究,第二届动物生物育种国际研讨会(分会报告,西安,2023);
[10]Genomic landscape of Chinese cattle, PAG ASIA (Online Conference, 2022);
[11]The tropical and subtropical adaptation and genetic diversity of Chinese local cattle based on the whole-genome data,PAG ASIA (深圳,2019);
[12]中国黄牛的遗传多样性来源,第二十次全国动物遗传育种学术讨论会 (广州,2019);