1．基本信息

朱斌，男，1985年12月生，湖北宜昌人，博士，教授，博士生导师。主要从事水产动物病害防控方面的教学和科研工作。入选西北农林科技大学“青年英才计划”、西北农林科技大学“卓越新星”、西北农林科技大学首批“高层次人才发展支持计划”青年拔尖人才。担任《水生生物学报》青年编委，《Journal of Virology》、《Aquaculture》、《Vaccine》、《Vaccines》、《Fish & Shellfish Immunology》和《Journal of Fish Diseases》等10多个期刊审稿人。

2．教育经历

2005年9月-2009年6月，西北农林科技大学动物科技学院，水产养殖学学士

2009年9月-2012年6月，西北农林科技大学动物科技学院，水生生物学硕士

2012年9月-2015年6月，西北农林科技大学动物科技学院，水生生物学博士

3．工作经历

2015年6月-2015年8月，西北农林科技大学动物科技学院，讲师

2015年9月-2021年12月，西北农林科技大学动物科技学院，副教授

2022年1月至今西北农林科技大学动物科技学院，教授

4．研究方向

[1] 水产疫苗设计与分子免疫机制；

[2] 水产纳米载药系统开发应用；

[3] 水产病原抗体诊断与靶向治疗。

5．开设课程与学生培养

承担本科生《水产动物免疫学》、《水产动物病害学实验》和研究生《水产动物病害学研究进展》等课程教学任务。主持课程建设项目3项，参与编写本科和研究生课程教材3部。

指导本科毕业论文19人，荣获校级百篇优秀毕业论文1人，校级优秀毕业论文2人，院级优秀毕业论文7人。指导大学生科创项目7项（国家级2项、省级2项、校级3项），发表SCI论文6篇，获第十届大学生创新创业论坛特等奖、全国大学生生命科学竞赛创新创业类一等奖等。

在读研究生10人（博士4人，硕士6人）。已毕业1名博士和12名硕士，1名博士入职海南大学，8名硕士继续攻读博士学位（厦门大学、华东师范大学、中国海洋大学和西北农林科技大学），2名硕士录取为选调生，1名硕士入职事业单位。研究生累计荣获国家奖学金7次、校长奖学金1次、陕西省优秀毕业生1次、校级优秀毕业生1次、校级优秀博士学位论文1次、校级优秀学术型硕士学位论文2次、校级优秀专业学位硕士学位论文2次、大学生创新创业大赛陕西省银奖、校级优秀研究生等。

6．主持科研项目

主持科研项目10余项，包括国家基金面上项目、国家基金青年基金、中国博士后基金特别资助、中国博士后基金面上项目、陕西省自然科学基金面上项目和青年项目等。

[1] 国家自然科学基金-面上项目（32173011），2022-2025。

[2] 国家自然科学基金-青年基金（31602204），2017-2019。

[3] 中国博士后科学基金-特别资助（2016T90956），2016-2017。

[4] 中国博士后科学基金-面上项目一等资助（2015M580888），2015-2017。

[5] 陕西省自然科学基础研究计划-面上项目（2019JM-035），2019-2020。

[6] 陕西省自然科学基础研究计划-青年人才项目（2016JQ3016），2016-2017。

[7] 陕西省博士后科学基金二等资助（2016BSHEDZZ114），2016-2017。

[8] 农业部渔用药物创制重点实验室开放课题（201602），2017-2018。

[9] 深圳万可森生物科技有限公司横向课题，2020-2021。

[10] 深圳万可森生物科技有限公司横向课题，2021-2022。

7．学术论文（第一^#或通讯作者论文*）

以第一作者或通讯作者在《Journal of Virology》、《Journal of Nanobiotechnology》、《Antiviral Research》、《Nanotoxicology》、《European Journal of Medicinal Chemistry》、《Chemosphere》、《Microbiology Spectrum》、《ACS Biomaterials Science & Engineering》、《Virus Research》、《Vaccine》、《Vaccines》、《Aquaculture》和《Fish & Shellfish Immunology》等期刊发表SCI论文74篇，累积影响因子373.7，其中包括中科院大类1区论文19篇、2区论文33篇，TOP期刊论文46篇。

2023年

[1] Gong Yu-Ming^#, Wei Xue-Feng^#, Zheng Yu-Ying, Li Yang, Yu Qing, Li Peng-Fei*, Zhu Bin*. Combining phage display technology with  in silico -designed epitope vaccine to elicit robust antibody responses against emerging pathogen Tilapia Lake Virus. Journal of Virology. 2023, 97(4):e00050-23. (IF="5.4，中科院2区)

[2] Zheng Yu-Ying^#, Li Yang^#, Sun Tian-Zi, Wei Xue-Feng, Liu Ming-Zhu, Li Peng-Fei*, Wang Gao-Xue*, Zhu Bin*. Inulin acetate as a novel recombinant subunit vaccine carrier for immunization of tilapia against tilapia lake virus. Aquaculture. 2023, 571:739439. (IF="4.5，中科院1区)

[3] Wei Xue-Feng, Gong Yu-Ming, Xia Jun-Yao, Liu Ming-Zhu, Li Peng-Fei*, Wang Gao-Xue*, Zhu Bin*. Biomimetic nanovaccine based on erythrocyte membrane enhances immune response and protection against Tilapia Lake Virus. Virology. 2023, 580:41-49. (IF="3.7，中科院3区)

2022年

[4] Zhang Chen, Zhao Zhao, Zhang Peng-Qi, Guo Sheng, Zhu Bin*. TLR2-mediated mucosal immune priming boosts anti-rhabdoviral immunity in early vertebrates. Antiviral Research. 2022, 203:105346. (IF="7.6，中科院2区)

[5] Zhang Chen, Zhang Peng-Qi, Guo Sheng, Zhao Zhao, Wang Gao-Xue*, Zhu Bin*. Dual-targeting polymer nanoparticles efficiently deliver DNA vaccine and induce robust prophylactic immunity against spring viremia of carp virus infection. Microbiology Spectrum. 2022, 10(5):e0308522. (IF="3.7，中科院1区)

[6] Zhao Zhao, Jiang Fu-Yi, Zhou Guo-Qing, Duan Hui-Xin, Xia Jun-Yao, Zhu Bin*. Protective immunity against spring viremia of carp virus by mannose modified chitosan loaded DNA vaccine. Virus Research. 2022, 320:198896. (IF="5.0，中科院3区)

[7] Zhang Chen, Guo Sheng, Chen Guo, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Mucosal delivery of mannose functionalized biomimetic nanoparticles via the branchial route induces robust mucosal and systemic immune responses against fish viral disease. Aquaculture. 2022, 546:737329. (IF="4.5，中科院1区)

[8] Gong Yu-Ming, Wei Xue-Feng, Zhou Guo-Qing, Liu Ming-Zhu, Li Peng-Fei*, Zhu Bin*. Mannose functionalized biomimetic nanovaccine enhances immune responses against tilapia. Aquaculture. 2022, 560:738535. (IF="4.5，中科院1区)

[9] Jia Yi-Jun, Xia Jun-Yao, Jiang Fu-Yi, Li Yang, Chen Guo, Zhu Bin*. Antigenic epitope screening and functional modification of mannose enhance the efficacy of largemouth bass virus subunit vaccines. Journal of Fish Diseases. 2022, 45: 1635-1643. (IF="2.5，中科院3区)

[10] Xu Fei-Fan, Jiang Fu-Yi, Zhou Guo-Qing, Xia Jun-Yao, Yang Fei, Zhu Bin*. The recombinant subunit vaccine encapsulated by alginate-chitosan microsphere enhance the immune effect against Micropterus Salmoides rhabdovirus. Journal of Fish Diseases. 2022, 45: 1757-1765. (IF="2.5，中科院3区)

[11] Zhao Zhao^#, Li Yang^#, Chen Guo, Zhang Chen, Wang Gao-Xue*, Zhu Bin*. Protective immunity against infectious spleen and kidney necrosis virus induced by mannose modified subunit vaccine with carbon nanotubes in mandarin fish. Aquaculture Research. 2022, 53:2175-2184. (IF="2.0，中科院3区)

2021年

[12] Zhao Zhao, Ma Rui, Guo Zi-Rao, Zhang Chen, Xiong Yan, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as drug carrier loaded with moroxydine hydrochloride against infectious spleen and kidney necrosis virus in mandarin fish. Aquaculture. 2021, 536:736469. (IF="4.5，中科院1区)

[13] Qiu De-Kui, Jia Yi-Jun, Gong Yu-Ming, Zheng Yu-Ying, Wang Gao-Xue, Zhu Bin*. Optimizing the immunization procedure of single-walled carbon nanotubes based vaccine against grass carp reovirus for grass carp. Aquaculture. 2021, 533:736152. (IF=4.5，中科院1区)

[14] Qiu De-Kui, Xiong Yan, Gong Yu-Ming, Zheng Yu-Ying, Ma Rui, Zhang Chen, Wang Gao-Xue, Zhu Bin*. Dominant antigen of Grass Carp Reovirus and immunity assessment with DNA vaccine for grass carp. Aquaculture. 2021, 530:735948. (IF="4.5，中科院1区)

[15] Zheng Yu-Ying, Qiu De-Kui, Guo Zi-Rao, Gong Yu-Ming, Wang Gao-Xue*, Zhu Bin*. Evaluation of SWCNTs-loaded DNA vaccine encoding predominant antigen epitope VP4-3 against type II GCRV. Aquaculture. 2021, 534:736197. (IF="4.5，中科院1区)

[16] Zheng Yu-Ying^#, Zhang Chen^#, Li Yang, Zhang Peng-Qi, Chen Guo, Wang Gao-Xue, Zhu Bin*. Immersion immunization of common carp with bacterial ghost-based DNA vaccine induces prophylactic protective immunity against spring viremia of carp virus. Journal of Fish Diseases. 2021, 44(12): 2021-2029. (IF="2.5，中科院3区)

[17] Gong Yu-Ming^#, Zhang Chen^#, Li Yang, Chen Guo, Wang Gao-Xue, Zhu Bin*. Optimization of immunization procedure for SWCNTs-based subunit vaccine with mannose modification against spring viremia of carp virus in common carp. Journal of Fish Diseases. 2021, 44(12): 1925-1936. (IF="2.5，中科院3区)

[18] Duan Hui-Xin^#, Zhao Zhao^#, Jin Ying-Jie, Wang Zi-Long, Deng Jie-Fang, He Jie, Zhu Bin*. PEG-modified subunit vaccine encoding dominant epitope to enhance immune response against spring viraemia of carp virus. Journal of Fish Diseases. 2021, 44(10):1587-1594. (IF="2.5，中科院3区)

[19] Liu Gao-Yang, Li Jian, Zhang Zhong-Yu, Liu Jing-Yao, Zhang Chen, Zhu Bin*, Wang Gao-Xue*. An immersion subunit vaccine loaded by single-walled carbon nanotube protects pearl gentian grouper from viral nervous necrosis virus. Aquaculture. 2021, 541:736813. (IF="4.5，中科院1区)

2020年

[20] Zhang Chen, Wang Gao-Xue, Zhu Bin*. Application of antigen presenting cell-targeted nanovaccine delivery system in rhabdovirus disease prophylactics using fish as a model organism. Journal of Nanobiotechnology. 2020, 18(1):24. (IF="10.2，中科院1区)

[21] Zhang Chen, Zhang Peng-Qi, Guo Sheng, Chen Guo, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Application of biomimetic cell-derived nanoparticles with mannose modification as a novel vaccine delivery platform against teleost fish viral disease. ACS Biomaterials Science & Engineering. 2020, 6(12):6770-6777. (IF=5.8，中科院2区)

[22] Zhao Zhao, Xiong Yan, Zhang Chen, Jia Yi-Jun, Qiu De-Kui, Wang Gao-Xue*, Zhu Bin*. Optimization of the efficacy of a SWCNTs-based subunit vaccine against infectious spleen and kidney necrosis virus in mandarin fish. Fish & Shellfish Immunology. 2020, 106:190-196. (IF=4.7，中科院2区)

[23] Liu Gao-Yang^#, Wang Er-Long^#, Qu Xiang-Yu, Yang Ke-Chen, Zhang Zhong-Yu, Liu Jing-Yao, Zhang Chen, Zhu Bin*, Wang Gao-Xue*. Single-walled carbon nanotubes enhance the immune protective effect of a bath subunit vaccine for pearl gentian grouper against Iridovirus of Taiwan. Fish & Shellfish Immunology. 2020.106:510-517. (IF="4.7，中科院2区)

[24] Zhang Chen, Guo Sheng, Zhao Zhao, Guo Zi-Rao, Ma Rui, Wang Gao-Xue, Zhu Bin*. Surface display of spring viremia of carp virus glycoprotein on  Lactococcus lactis and its protection efficacy in common carp ( Cyprinus carpio L.). Fish & Shellfish Immunology. 2020, 104:262-268. (IF="4.7，中科院2区)

[25] Zhao Zhao, Zhang Chen, Jia Yi-Jun, Wang Gao-Xue*, Zhu Bin*.  In vivo efficacy of ganciclovir by using single-walled carbon nanotubes as a drug carrier against infectious spleen and kidney necrosis virus in mandarin fish. Aquaculture. 2020, 526:735434. (IF="4.5，中科院1区)

[26] Huang Ai-Guo, Tan Xiao-Ping, Cui Hai-Bo, Qi Xiao-Zhou, Zhu Bin*, Wang Gao-Xue*. Antiviral activity of geniposidic acid against white spot syndrome virus replication in red swamp crayfish  Procambarus clarkia . Aquaculture. 2020, 528:735533. (IF="4.5，中科院1区)

[27] Jia Yi-Jun, Guo Zi-Rao, Ma Rui, Qiu De-Kui, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Immune efficacy of carbon nanotubes recombinant subunit vaccine against largemouth bass ulcerative syndrome virus. Fish & Shellfish Immunology. 2020, 100:317-323. (IF="4.7，中科院2区)

[28] Guo Zi-Rao, Zhao Zhao, Zhang Chen, Jia Yi-Jun, Qiu De-Kui, Zhu Bin*, Wang Gao-Xue*. Carbon nanotubes-loaded subunit vaccine can increase protective immunity against rhabdovirus infections of largemouth bass ( Micropterus Salmoides ). Fish & Shellfish Immunology. 2020, 99:548-554. (IF="4.7，中科院2区)

[29] Zhao Zhao, Zhang Chen, Lin Qiang, Li Ning-qiu, Huang Zhi-Bin, Zhao Mi, Fu Xiao-Zhe*, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of an immersion DNA vaccine against infectious spleen and kidney necrosis virus in mandarin fish. Fish & Shellfish Immunology. 2020, 97:432-439. (IF="4.7，中科院2区)

[30] Zhang Zhong-Yu, Liu Gao-Yang, Ma Rui, Qi Xiao-Zhou, Wang Gao-Xue, Zhu Bin*, Ling Fei*. The immunoprotective effect of whole-cell lysed inactivated vaccine with SWCNT as a carrier against  Aeromonas hydrophila infection in grass carp. Fish & Shellfish Immunology. 2020, 97:336-343. (IF="4.7，中科院2区)

[31] Qiu De-Kui, Zhao Zhao, Ma Rui, Guo Zi-Rao, Jia Yi-Jun, Zhang Chen, Wang Gao-Xue, Zhu Bin*. Antigen epitope screening of grass carp reovirus and its protectively immunity assessment for grass carp. Aquaculture. 2020, 515:734550. (IF="4.5，中科院1区)

[32] Zhu Bin^#*, Zhang Chen^#, Zhao Zhao, Wang Gao-Xue. Targeted delivery of mannosylated nanoparticles improve prophylactic efficacy of immersion vaccine against fish viral disease. Vaccines. 2020, 8(1):87. (IF="7.8，中科院3区)

[33] Jia Yi-Jun, Guo Zi-Rao, Ma Rui, Qiu De-Kui, Wang Gao-Xue, Zhu Bin*. Protective immunity of largemouth bass immunized with immersed DNA vaccine against largemouth bass ulcerative syndrome virus. Fish & Shellfish Immunology. 2020, 107:269-276. (IF="4.7，中科院2区)

8．发明专利

[1] Zhu Bin. TiLV-2 protein or gene encoding TiLV-2 protein in preparation of subunit vaccine against Tilapia lake virus. Date of grant: 2022-6-3, Netherlands, Patent Number: 2028806.

[2] Zhu Bin, Zhang Chen, Guo Sheng. Dual-targeting DNA vaccine of spring viraemia of carp virus and a preparation method thereof. Date of grant: 2021-10-27, South African, Patent Number: 2021/05991.

[3] 王高学，朱斌，凌飞，郭孜饶，焦铁军. 一种鲈鱼弹状病毒亚单位疫苗及其制备方法，2021.11，中国，授权号ZL202111066165.5。

[4] 王高学，朱斌，凌飞，郭孜饶，焦铁军. 一种鲈鱼弹状病毒重组G2蛋白及其应用，2021.11，中国，授权号ZL202111066177.8。

[5] 王高学，朱斌，刘广路，凌飞. 碳纳米管载体免注射疫苗、制备方法及其在制备水产免疫苗种中的应用，2016.01，中国，授权号ZL201310482649.7.

[6] 王高学，刘广路，朱斌，凌飞. 碳纳米管载抗病毒药物复合物、制备方法及其在水产养殖无病毒携带苗生产中的应用，2016.01，中国，授权号ZL201310482759.3.

[7] 王高学，赵昭，朱斌，凌飞，马瑞，龚宇明. 截短表达的鳜传染性脾肾坏死病毒主衣壳蛋白及其应用，2023.07，中国，授权号ZL202111449927.X.

9．联系方式

通讯地址：陕西杨凌西农路22号 西北农林科技大学动物科技学院

邮编：712100

电话：13572487467

E-mail：zhubin1227@126.com  zhubin@nwsuaf.edu.cn