一、 基本信息

吴江维，女，博士，博士生导师，西北农林科技大学动物科技学院三级教授。入选国家级青年人才、陕西省人才计划、陕西省中青年科技领军人才，获全国优秀博士学位论文、陕西青年科技奖、陕西青年科技标兵等荣誉奖励。

现为国家自然科学基金委员会生命科学部通讯评议专家、教育部学位中心学位论文评审专家、中国畜牧兽医学会动物遗传育种学分会理事、中国细胞生物学学会细胞代谢分会委员、陕西省细胞生物学学会理事、中国生物化学与分子生物学报编委。兼任《PLOS Biology》Academic Editor,《Frontiers in Cell and Developmental Biology》Guest associate editor，担任Cell Metabolism、Signal Transduction and Targeted Therapy、生物化学与生物物理进展等数个国内外期刊审稿人。以通讯作者在 Cell Metabolism （亮点文章）、 Nature Communications 、 Advanced Science 及 PLOS Biology 等期刊发表30余篇学术论文。

二、学习工作经历

2016/09-至今西北农林科技大学，教授

2012/04-2016/04，加拿大蒙特利尔大学，博士后

2011/07-2012/03，加拿大蒙特利尔大学，研究助理

2008/09-2011/05，加拿大蒙特利尔大学，联合培养博士

2006/09-2011/07，西北农林科技大学，动物科技学院，博士

2003/09-2006/07，西北农林科技大学，动物科技学院，硕士

1999/09-2003/07，西北农林科技大学，动物科技学院，学士

三、研究方向

1）猪肉品质改良：

通过分析大规模猪群体表型和环境因子数据，从遗传变异、环境变异和营养因素三个层面解析优质猪肉形成的调控机制，明确关键基因、功能突变和环境因子在表型变异中的作用，为优质猪肉生产提供依据。

2）动物糖脂代谢调控：

以实践应用潜能为出发点，围绕动物糖脂代谢紊乱问题，通过系统的生物信息学和网络药理学筛选并鉴定具有调控动物糖脂稳态的天然小分子，推动基础研究成果的转化应用。

四、主持项目

1）主持项目/课题：

1．国家自然科学基金面上项目，基于内质网应激信号通路探究ASGR1基因缺失导致肝损伤的机制，2024-2027

2. 十四五国家重点研发计划课题，猪高产优质高效性状形成的调控网络及多基因互作机制，2021-2026

3. 科技创新2030—重大项目子课题，猪优质高产性状功能基因和变异位点鉴定，2023-2025

4. 国家自然科学基金面上项目，利用CRISPR-Cas9技术构建ASGR1基因敲除猪作为人类动脉粥样硬化疾病模型的研究，2021-2024

5. 陕西省创新能力支撑计划项目

，肌肉生物学与猪遗传改良创新团队，2023-2025

6. 十三五国家重点研发计划子课题，日粮组成与饲养体制对畜禽健康优质肉形成的调控及机制，2018-2020

7. 陕西省“**********计划”创新全职项目，2017-2022

8. 西北农林科技大学科研启动经费，脂代谢在动物肌内脂肪沉积和肌肉发育中的作用及其调控机理，2016-2021

9. 陕西省重点研究计划，转录因子ZBED6在调控猪骨骼肌生长发育中的作用及其机制研究，2020-2021

10. 生命科学教学科研平台配套设备购置项目，2021-2022

11. 中央高校基本科研业务费专项资金项目-科技创新专项项目， 2018.1-2018.12

五、代表性论文（#并列第一作者；*通讯作者）

1.Zhe Zhang^#, Xiang Kai Leng^#, Yuan Yuan Zhai^#, Xiao Zhang, Zhi Wei Sun, Jun Ying Xiao, Jun Feng Lu, Kun Liu, Bo Xia, Qi Gao, Miao Jia, Cheng Qi Xu, Yi Na Jiang, Xiao Gang Zhang*, Kai Shan Tao*, Jiang Wei Wu*, Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress,  Nature communications , 2024 Mar 8. (西北农林科技大学高质量期刊G1, 通讯作者, 2023年影响因子16.6, 中科院1区TOP期刊)

2.Jun Feng Lu^#, Meng Qing Zhu^#, Bo Xia^#, Na Na Zhang^#, Xiao Peng Liu, Huan Liu, Rui Xin Zhang, Jun Ying Xiao, Hui Yang, Ying Qi Zhang, Xiao Miao Li*, Jiang Wei Wu*. GDF15 is a major determinant of ketogenic diet-induced weight loss. Cell Metabolism. 2023 Dec 5. (西北农林科技大学高质量期刊G1, 通讯作者, 2023年影响因子29.0, 中科院1区TOP期刊)

3.Huan Liu^#, Dengke Pan^#, Pu Li^#, Dandan Wang^#, Bo Xia, Ruixin Zhang, Junfeng Lu, Xiangyang Xing, Jiaxiang Du, Xiao Zhang, Long Jin, Lin Jiang*,  Linong Yao*, Mingzhou Li*, Jiangwei Wu*. Loss of ZBED6 Protects Against Sepsis-Induced Muscle Atrophy by Upregulating DOCK3-Mediated RAC1/PI3K/AKT Signaling Pathway in Pigs.  Advanced Science.  2023 Aug 7. (西北农林科技大学高质量期刊G1，通讯作者, 2023年影响因子15.1, 中科院1区TOP期刊)

4.Luxi Chen^#, Jing Li^#, Renqiang Yuan^#, Yujie Wang^#, Jiaman Zhang^#, Yu Lin^#, Lina Wang, Xingxing Zhu, Wei Zhu, Jingyi Bai, Fanli Kong, Bo Zeng, Lu Lu, Jideng Ma, Keren Long, Long Jin, Zhiqing Huang, Jinlong Huo, Yiren Gu, Danyang Wang, Delin Mo, Diyan Li, Qianzi Tang, Xuewei Li, Jiangwei Wu*, Yaosheng Chen*, Mingzhou Li*.Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver. Cell Discovery . 2022 Jun 14. (通讯作者, 2023年影响因子33.5, 中科院1区TOP期刊)

5.Xiao Chen Shi#, Bo Xia#, Jian Feng Zhang, Rui Xin Zhang, Dan Yang Zhang, Huan Liu, Bao Cai Xie, Yong Liang Wang*, Jiang Wei Wu*. Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β.  PLOS Biology . 2022 Apr 27. (通讯作者, 2023年影响因子9.8, 中科院1区TOP期刊)

6.Jun Feng Lu#, Meng Qing Zhu#, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Rui Xin Zhang, Bo Xia, Jiang Wei Wu*. Camptothecin effectively treats obesity in mice through GDF15 induction.  PLOS Biology . 2022 Feb 24. (通讯作者, 2023年影响因子9.8, 中科院1区TOP期刊)

7.Bo Xia#, Xiao Chen Shi#, Bao Cai Xie#, Meng Qing Zhu, Yan Chen, Xin Yi Chu, Guo He Cai, Min Liu, Shi Zhen Yang, Grant A. Mitchell, Wei Jun Pang*, Jiang Wei Wu*. Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.  PLOS Biology . 2020 Mar 27. (通讯作者, 2023年影响因子9.8, 中科院1区TOP期刊)

8.Yongliang Wang, Huan Liu, Ruixin Zhang, Yuyao Xiang, Junfeng Lu, Bo Xia*, Liang Peng*, Jiangwei Wu*. AdipoRon exerts opposing effects on insulin sensitivity via fibroblast growth factor 21–mediated time-dependent mechanisms.Journal of Biological Chemistry . 2022 Jan 25 . (通讯作者, 2023年影响因子4.8, 中科院2区TOP期刊)

9.Dandan Wang#, Denke Pan#, Baocai Xie#, Shengnan Wang, Xiangyang Xing, Xuexue Liu, Yuehui Ma, Leif Andersson, Jiangwei Wu*, Lin Jiang*.  Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets.  PLOS Genetics . 2021 Oct 28. (通讯作者, 2023年影响因子4.5, 中科院2区TOP期刊)

10. Bao Cai Xie#, Xiao Chen Shi#, Yan Li#, Bo Xia, Jia Zhou, Minjie Du, Xiangyang Xing, Liang Bai, Enqi Liu, Fernando Alvarez, Long Jin, Shaoping Deng, Grant A. Mitchell, Dengke Pan*, Mingzhou Li*, Jiangwei Wu*. Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans.  PLOS Genetics . 2021 Nov 11. (通讯作者, 2023年影响因子4.5, 中科院2区TOP期刊)

11. Jiang Wei Wu*^#, Christoph Preuss^#, Shu Pei Wang, Hao Yang, Bo Ji, Gregory W. Carter, Rebecca Gladdy, Gregor Andelfinger*, Grant A. Mitchell*. Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.  PLOS Genetics . 2017 May 1. (通讯作者, 2023年影响因子4.5, 中科院2区TOP期刊)

12. Bo Xia^#, Guo He Cai^#, Hao Yang, Shu Pei Wang, Grant A. Mitchell*, Jiang Wei Wu*, Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice.  PLOS Genetics . 2017 Dec 12. (通讯作者, 2023年影响因子4.5, 中科院2区TOP期刊)

13. Jiang Wei Wu, Hao Yang, Grant A. Mitchell*. Potential Mechanism Underlying the PNPLA3I148M-Hepatic Steatosis Connection.  Hepatology . 2015 Jun 19. (第一作者，2023年影响因子13.5，中科院1区TOP期刊)

14. Jiang Wei Wu, Shu Pei Wang, Fernando Alvarez, Stéphanie Casavant, Nicolas Gauthier, Lynda Abed, Krishnakant G. Soni, Gongshe Yang*, Grant A. Mitchell*. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis.  Hepatology . 2011 Apr 04. (第一作者，2023年影响因子13.5，中科院1区TOP期刊)

15. Baocai Xie^#, Dengke Pan^#, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu^*. Diosmetin Protects Against Obesity and Metabolic Dysfunctions Through Activation of Adipose Estrogen Receptors in Mice.  Molecular Nutrition & Food Research . 2021 Jul 05. (通讯作者, 2023年影响因子5.2, 中科院1区TOP期刊)

六、其他论文

1.Jianfeng Zhang^#, Jiangwei Wu^#, Xiaochen Shi, Defu Li, Shizhen Yang, Ruixin Zhang, Bo Xia, Gongshe Yang^*. A Propolis-Derived Small Molecule Tectochrysin Ameliorates Type 2 Diabetes in Mice by Activating Insulin Receptor β.  Molecular Nutrition & Food Research . 2023 October 27. (共同第一作者, 2023年影响因子5.2 中科院1区TOP期刊)

2.Yuyao Xiang^#, Ruolan Huang^#, Yongliang Wang^#, Shanshan Han^#, Xiaochen Qin^#, Zhenzhen Li, Xu Wang, Yuqing Han, Tao Wang, Bo Xia, Jiangwei Wu, Gongshe Yang^*. Protocatechuic acid ameliorates high fat diet-induced obesity and insulin resistance in mice.  Molecular Nutrition & Food Research . 2023 October 14. (参与作者, 2023年影响因子5.2, 中科院1区TOP期刊)

3.Xin Yi Chu^#, Cong Cong Zhang^#, Rui Xin Zhang, Jian Feng Zhang, Bo Xia, Jiang Wei Wu^*. Identification of Dacinostat as a potential anti-obesity compound through transcriptional activation of adipose thermogenesis in mice.  BBA-Molecular Basis of Disease . 2021 May 15. (通讯作者, 2023年影响因子6.633, 中科院2区期刊)

4.Xin Zhang, Doudou Xu, Meixia Chen, Yubo Wang, Linjuan He, Lu Wang, Jiangwei Wu, Jingdong Yin^*. Impacts of Selected Dietary Nutrient Intakes on Skeletal Muscle Insulin Sensitivity and Applications to Early Prevention of Type 2 Diabetes.  Advances in Nutrition . 2021 Jan 8. (参与作者, 2023年影响因子9.3 中科院1区TOP期刊)

5.Jun Feng Lu^#, Meng Qing Zhu^#, Heng Zhang, Hao Liu, Bo Xia, Yong Liang Wang, Xin’e Shi, Liang Peng^*, Jiang Wei Wu^*. Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high-fat diet-fed mice.  The FASEB Journal . 2020 Jul 30. (通讯作者, 2023年影响因子5.834, 中科院2区TOP期刊)

6.Yan Chen^#, Guo He Cai^#, Bo Xia, Xin Wang, Cong Cong Zhang, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Jun Feng Lu, Rui Xin Zhang, Meng Qing Zhu, Min Liu, Shi Zhen Yang, Dan Yang Zhang, Xin Yi Chu, Rajwali Khan, Yong Liang Wang, Jiang Wei Wu^*. Mitochondrial aconitase controls adipogenesis through mediation of cellular ATP production.  The FASEB Journal . 2020 Mar 24. (通讯作者, 2023年影响因子5.834, 中科院2区TOP期刊)

7.Xin Yi Chu, Shi Zhen Yang, Meng Qing Zhu, Dan Yang Zhang, Xiao Chen Shi, Bo Xia, Ye Yuan, Min Liu, Jiang Wei Wu^*. Isorhapontigenin Improves Diabetes in Mice via Regulating the Activity and Stability of PPARgamma in Adipocytes.  Journal of Agricultural and Food Chemistry . 2020 Mar 16. (通讯作者, 2023年影响因子6.1, 中科院1区TOP期刊)

8.Xin Wang^#, Min Liu^#, Guo He Cai, Yan Chen, Xiao Chen Shi, Cong Cong Zhang, Bo Xia, Bao Cai Xie, Huan Liu, Rui Xin Zhang, Jun Feng Lu, Meng Qing Zhu, Shi Zhen Yang, Xin Yi Chu, Dan Yang Zhang, Yong Liang Wang, Jiang Wei Wu^*. A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion.  Cells . 2020 Jan 31. (通讯作者, 2023年影响因子6.0, 中科院2区期刊)

9.Xiao Zhang, Cong Cong Zhang, Hao Yang, Krishnakant G. Soni, Shu Pei Wang, Grant A. Mitchell^*, Jiang Wei Wu^*. An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis.  Cells . 2019 Apr 29. (通讯作者, 2023年影响因子6.0, 中科院2区期刊)

10. Hao Yang, Jiang Wei Wu, Shu Pei Wang, Ilenia Severi, Loris Sartini, Norma Frizzell, Saverio Cinti, Gongshe Yang^*, Grant A. Mitchell^*. Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance.  Diabetes . 2012 Dec. (参与作者, 2023年影响因子9.79, 中科院1区TOP期刊)

11. Jiang Wei Wu, Hao Yang, Shu Pei Wang, Krishnakant G. Soni, Catherine Brunel-Guitton & Grant A. Mitchell^*. Inborn errors of cytoplasmic triglyceride metabolism.  Journal of Inherited Metabolic Disease . 2014 Oct 10. (Invited review第一作者, 2023年影响因子4.2, 中科院2区期刊)

12. Jiang Wei Wu, Shu Pei Wang, Stéphanie Casavant, Alain Moreau, Gong She Yang, Grant A. Mitchell^*. Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase.  Endocrinology . 2012 May 01. (第一作者, 2023年影响因子4.8, 中科院2区TOP期刊)

七、培养学生

指导研究生37名，在读18名（博士生10名，硕士生8名）；毕业19名。其中，指导学生获得国家奖学金、校长奖学金、校优秀博士学位论文、校优秀硕士学位论文、校优秀共产党员、优秀研究生和优秀毕业生等荣誉累计40余次。

八、招生学科

动物遗传育种与繁殖（博士，学硕），畜牧（专硕），动物营养与饲料科学（博士，学硕），欢迎考生邮件联系。

九、联系方式

通讯地址：陕西杨凌西农路22号西北农林科技大学动物科技学院

邮编：712100

Email: wujiangwei@nwafu.edu.cn