Huiping Xue

　　 　　

Basic information

Huping Xue received his PhD from Fudan University. He studied at McGill University from 2009 to 2011 and started to work in 2012 at the College of Animal Science and Technology, Northwest A&F University. He is now an associate professor, PhD supervisor, evaluating expert of NSFC, communication review expert for dissertations of the Ministry of Education in China, delegate to the national genetics congress, standing member of Shaanxi Pharmacological Society and member of Chinese society of microbiology.

Research direction and courses offered

Research Direction: With the comprehensive implementation of the policy of " Antibiotics are prohibited in feeding and restricted in breeding", it is urgent to develop antibiotic substitutes. Focusing on the needs, we are committed to the research of antimicrobial peptides: (1) Mining new antimicrobial peptides and antibacterial agents from natural products, and reforming them; (2) The mechanism of antimicrobial peptides was elucidated by using Staphylococcus aureus as target bacteria; (3) Escherichia coli, Bacillus subtilis, lactic acid bacteria and Pichia pastoris were used as expression hosts to construct high expression system of antimicrobial peptides and achieve large-scale production of antimicrobial peptides.

The research group has instruments and equipment worth 10 million, related to molecular biology, cell biology and microbiology research. Students who are interested in bacteriology research are welcome to apply for it.

Academic achievements

1. Yifei Cai, Liangjun Zheng, Yao Lu, Xu Zhao, Yanting Sun, Xingyuan Tang, Jinhe Xiao, Chen Wang, Chao Tong, Lili Zhao, Yingping Xiao, Xin Zhao, Huping Xue*. 2021. Inducible resistance to β-lactams in oxacillin-susceptible meca1-positive Staphylococcus sciuri isolated from retail pork. Frontiers in Microbiology. 12:721426.

2. Xingxing Li, Dongliang Liu, Zhaowei Wu, Dan Li, Yifei Cai, Yao Lu, Xin Zhao, Huping Xue*. 2020. Multiple Tolerance and Dye Decolorization Ability of a Novel Laccase Identified from Staphylococcus Haemolyticus. Journal of microbiology and biotechnology. 30(4):1-7.

3. Zhaowei Wu, Limin Zhang, Dandan Qiao, Huping Xue* and Xin Zhao*. 2018. Functional Analyses of Cassette Chromosome Recombinase C2 (CcrC2) and Its Use in Eliminating Methicillin Resistance by Combining CRISPR−Cas9. ACS Synthetic Biology. 16;7(11):2590-2599

4. Chao Tong, Zhaowei Wu, Xin Zhao and Huping Xue*. 2018. Arginine Catabolic Mobile Elements in Livestock-Associated Methicillin-Resistant Staphylococcal Isolates from Bovine Mastitic Milk in China. Frontiers in Microbiology. 16;9:1031.

5. Liangliang Wang, Wei Si, Huping Xue and Xin Zhao. 2018. Characterization of a functional insertion sequence ISSau2 from Staphylococcus aureus. Mobile DNA. 9:3

6. Pilong Liu, Zhaowei Wu, Huping Xue and Xin Zhao. 2017.Antibiotics trigger initiation of SCCmec transfer by inducing SOS responses. Nucleic Acids Research. 20;45(7):3944-3952.

7. Liangliang Wang, Wei Si, Huping Xue and Xin Zhao. 2017. A fibronectin‐binding protein (FbpA) of  Weissella cibaria  inhibits colonization and infection of  Staphylococcus aureus  in mammary glands. Cellular Microbiology. 19(8)，e12731

8. Huping Xue, Zhaowei Wu, Dandan Qiao, Chao Tong and Xin Zhao. 2017. Global acquisition of genetic materials from different bacteria into the staphylococcal cassette chromosome elements of a  Staphylococcus epidermidis . International Journal of Antimicrobial Agents. S0924-8579(17)30264-9.

9. Pilong Liu#, Huping Xue#, Zhaowei Wu, Junfei Ma and Xin Zhao. 2016. Effect of bla regulators on the susceptible phenotype and phenotypic conversion for oxacillin-susceptible mecA-positive staphylococcal isolates. Journal of Antimicrobial Chemotherapy. 71(8):2105-12.

10. Huping Xue, Zhaowei Wu, Fan Li, Longping Li, Yiqing Wang and Xin Zhao. 2015. Coexistence of heavy metal and antibiotic resistance within a novel composite staphylococcal cassette chromosome in a  Staphylococcus haemolyticus  isolate from bovine mastitis milk. Antimicrobial Agents and Chemotherapy. 59:5788-5792.

11. Zhaowei Wu, Fan Li, Dongliang Liu, Huping Xue* and Xin Zhao*. 2015. Novel type XII staphylococcal cassette chromosome mec harboring a new cassette chromosome recombinase, CcrC2. Antimicrobial Agents and Chemotherapy. 59(12):7597-7601.

12. Longping Li, Luoxiong Zhou, Lihong Wang, Huping Xue and Xin Zhao. 2015. Characterization of methicillin-resistant and -susceptible staphylococcal isolates from bovine milk in Northwestern China. PLoS One 10:e0116699.

13. Longping Li, Weiwei Feng, Zhiping Zhang, Huping Xue and Xin Zhao. 2015. Macrolide-lincosamide-streptogramin resistance phenotypes and genotypes of coagulase-positive  Staphylococcus aureus  and coagulase-negative staphylococcal isolates from bovine mastitis. BMC Vet. Res. 11:168.

14. Zhaowei Wu, Wei Si, Huping Xue, MingmingYang and Xin Zhao. 2015. Molecular characterization and expression profiling of novel laccase isoenzymes from  Fusarium solani  X701, a wood-rotting ascomycete. Int. Biodeterior. Biodegr. 104:123-128.

15. Liangliang Wang, Huping Xue, Longping Li and Xin Zhao. 2015. Characterization of Insertion Sequence ISSau2 in the Human and Livestock-Associated  Staphylococcus aureus.  PLoS One 10(5): e0127183

16. Xue Huping, Zhou Jungang, You Chun, Huang Qiang and Lu Hong. 2012. Amino acid substitutions in the n-terminus, cord and alpha-helix domains improved the thermostability of a family 11 xylanase Xynr8. J Ind Microbiol Biotechnol. 39(9):1279-88

17. Cheng Jing, Xue Huping# and Zhao Xin. 2012. Variation of serine-aspartate repeats in membrane proteins possibly contributes to staphylococcal microevolution. PLoS One. 7(4):e34756

18. Xue Huping, Lu Hong and Zhao Xin. 2011. Sequence diversities of serine-aspartate repeat genes among  Staphylococcus aureus  isolates from different hosts presumably by horizontal gene transfer. PLoS One. 6(5):e20332

19. You Chun, Huang Qiang, Xue Huping, Xu Yang and Lu Hong. 2010. Potential hydrophobic interaction between two cysteines in interior hydrophobic region improves thermostability of a family 11 xylanase from  Neocallimastix patriciarum . Biotechnol Bioeng. 105(5):861-70

Honors and awards

1. Basic Research on the Generation, Transmission and Prevention and control of Antibiotic resistance in Bovine Mastitis Staphylococcus aureus, 2019, Science and Technology Award of Shaanxi Province, Second prize of Natural Science (the first winner);

2. Director of university-level excellent style of study demonstration class.

Scientific research projects

1, National Natural Science Foundation of China (NSFC): Characterization and network analysis of CRP stress response in a novel expression regulation system of Staphylococcus aureus, 31972652, 2020.01-2023.12;

2, National Natural Science Foundation of China for Young Science Foundation project: Molecular mechanism of staphylococcus ccrC2 gene affecting the transmission of methicillin-resistant bacteria, 31602023, 2017.01-2019.12;

3, China postdoctoral fund project: on the surface of the cell wall anchor protein SdrD influence s. aureus bacteria biofilm formation mechanism research, 2015 m572606, 2016.01-2017.12;

4. Fundamental Research Funds for the Central Universities: Effect and mechanism of functional complementarity and sequence difference of sdrE gene on The virulence of Staphylococcus aureus, 2014.01-2017.01;

5. Ph.D. research fund, Northwest A& F University. Effects of SDRS on the adaptive microevolution of Staphylococcus aureus and its molecular mechanism.

Contact information

Address: Scientific Research Building 4208, South Campus, Northwest A&F University, No. 3 Tai Cheng Road, Yangling Demonstration Area, Shaanxi Province

Email address: xuehuping@hotmail.com