Ruihua Dang

　　 　　

Ruihua Dang, Associate Professor

College of Animal Science and Technology

Northwest A&F University

Yangling, Shaanxi 712100 China

Telephone: 029-87092164

Fax: 029-87092164

Email: dangruihua@nwsuaf.edu.cn

Education:

B.S., Northwest A&F University, Animal Science 1996-2000

M.S., Northwest A&F University, Animal Breeding and Genetics 2002-2005

Ph.D., Hokkaido University(Japan), Veterinary Medicine 2008-2012

Research Interests:

Research interests include analysis of genetic diversity and evolution, genetic variations and function in livestock, and identification of susceptibility genes for Hirschsprung disease.

Teaching:

Animal Genetics

GRANTS:

PI of the project "Fine mapping and fuction study of the immunodeficiency-associated genes of Hirschsprung disease" , funded by the National Natural Science Foundation of China (2018-2021)

PI of the project "Identification of the unknown susceptible genes of Hirschsprung disease and the associated immunodeficiency" , funded by the National Natural Science Foundation of China (2013-2016)

PI of the project "Identification of harmful variation of genes related to genetic defects in Qinchuan cattle and establishment of rapid detection method" , funded by the Key R & D plan of Shaanxi Province (2017-2018)

PI of the project "Development and application of molecular markers for meat and milk traits of Guanzhong donkey" , funded by the Key R & D plan of Shaanxi Province (2020-2021)

Publications: (selected publications from peer-reviewed journals)

1. Lai Zhenyu, Wu Fei, Li Mei, Bai Fuxia,Gao Yuan, Yu Jie, Li Haijing, Lei Chuzhao, Dang Ruihua*. Tissue expression profile, polymorphism of IGF1 gene and its effect on body size traits of Dezhou donkey.Gene. 2021 Jan 15;766:145118. doi:10.1016/j.gene.2020.145118. Epub 2020 Sep 4.

2. Lai ZY, Wu F, Zhou ZH, Li M, Gao Y, Yin GJ, Yu J, Lei CZ, Dang RH*. Expression profiles and polymorphic identification of the ACSL1 gene and their association with body size traits in Dezhou donkeys. ARCHIVES ANIMAL BREEDING. NOV 10 2020. 63(2):377-386.

3. Zihui Zhou, Yingzhi Fan, Gang Wang, Zhenyu Lai, Yuan Gao, Fei Wu, Chuzhao Lei, Ruihua Dang*. Detection of Selection Signatures Underlying Production and Adaptive Traits Based on whole-Genome Sequencing of Six Donkey Populations. Animals (Basel). 2020 Oct7;10(10):1823.

4. Zhenyu Lai, Shipeng Li, Fei Wu, Zihui Zhou, Yuan Gao, Jie Yu, Chuzhao Lei, Ruihua Dang*. Genotypes and haplotype combination of ACSL3 gene sequence variants is associated with growth traits in Dezhou donkey.Gene.2020 Jun 15;743:144600. Epub 2020 Mar 23.

5. Yuan Gao, Fei Wu, Yaxuan Ren, Zihui Zhou, Ningbo Chen, Yongzhen Huang, Chuzhao Lei, Hong Chen, Ruihua Dang*. MiRNAs Expression Profiling of Bovine (Bos taurus) Testes and Effect of bta-miR-146b on Proliferation and Apoptosis in Bovine Male Germline Stem Cells. Int J Mol Sci. 2020 May 28;21(11):3846.

6. Fang X, Lai Z, Liu J, Zhang C, Li S, Wu F, Zhou Z, Lei C, Dang R*. A Novel 13 bp Deletion within the NR6A1 Gene Is Significantly Associated with Growth Traits in Donkeys.Animals.2019 Sep 14;9(9). pii: E681. doi: 10.3390/ani9090681.

7. Wu ML, Li SP, Zhang GL, Fan, YZ, Gao Y, Huang, YZ,  Lan, XY, Lei CZ, Ma Y, Dang RH*. Exploring insertions and deletions (indels) of MSRB3 gene and their association with growth traits in four Chinese indigenous cattle breeds. ARCHIVES ANIMAL BREEDING.2019 JUL 25;62: 465-475.

8. Gao Y, Li S, Lai Z, Zhou Z, Wu F, Huang Y, Lan X, Lei C, Chen H, Dang R*.Analysis of Long Non-Coding RNA and mRNA Expression Profiling in Immature and Mature Bovine (Bos taurus) Testes. Front Genet.2019 Jul 5;10:646.doi: 10.3389/fgene.2019.00646. eCollection 2019.

9. Gao Y, Wu M, Fan Y, Li S, Lai Z, Huang Y, Lan X, Lei C, Chen H, Dang R*.Identification and characterization of circular RNAs in Qinchuan cattle testis.R Soc Open Sci. 2018 Jul 25;5(7):180413. doi: 10.1098/rsos.180413. eCollection 2018 Jul.

10. Sun T, Li S, Xia X, Ji C, Shen S, Zhang G, Yu J, Jiang G, Dang R*, Lei C*.ASIP gene variation in Chinese donkeys.Anim Genet. 2017 Jun;48(3):372-373.

11. Chen N, Wang F, Yu N, Gao Y, Huang J, Dang R*, Huang Y, Lan X, Lei C, Chen H. Polymorphisms in MX2 Gene Are Related with SCS in Chinese Dairy Cows. Anim Biotechnol.2017 May 4:1-9.

12. Chen NB, Wang FQ, Yu NQ, Gao Y, Huang JP, Huang YZ, Lan XY, Lei CZ, Chen H, Dang RH*.Genetic Variations of the Bovine MX1 and Their Association with Mastitis.CZECH J ANIM SCI.2017, 62 (No.4):157-167.

13. Huang J, Dang R*, Torigoe D, Lei C, Lan X, Chen H, Sasaki N, Wang J, Agui T. Identification of genetic loci affecting the severity of symptoms of Hirschsprung disease in rats carrying Ednrb(sl) mutations by quantitative trait locus analysis. PLoS One. 2015 Mar 19; 10(3): e0122068 (2015).

14. Huang J, Dang R*, Torigoe D, Li A, Lei C, Sasaki N, Wang J, Agui T. Genetic variation in the GDNF promoter affects its expression and modifies the severity of Hirschsprung's disease (HSCR) in rats carrying Ednrb(sl) mutations. Gene. 2016 Jan 1;575(1):144-8. Epub 2015 Aug 28.

15. Huang J, Dang R*, Torigoe D, Li A, Lei C, Sasaki N, Wang J, Agui T. QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrb(sl) mutations. Sci Rep. 2016 Jan 22;6:19697.

16. Han HY, Mao CC, Chen NB, Lan, XY, Chen H, Lei CZ, Dang RH*. Single nucleotide polymorphisms of Kit gene in Chinese indigenous horses. Jpn J Vet Res. 2016 Feb;64(1):81-9.

17. Gao KX, Chen NB, Liu WJ, Li R, Lan XY, Chen H, Lei CZ, Dang RH*. Frequency of gray coat color in native Chinese horse breeds.Genet Mol Res. 2015 Oct 30;14(4):14144-50.

18. Dang, R., Torigoe, D., Suzuki, S., Kikkawa, Y., Moritoh, K., Sasaki, N. and Agui, T. (2011) Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying ednrbsl mutations. PLoS. One 6: e24086.

19. Dang, R., Torigoe, D., Sasaki, N. and Agui, T. (2011) QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrbsl mutations. PLoS. One 6: e27902.

20. Dang, R., Torigoe, D., Sasaki, N. and Agui, T. （2012）Anatomic modifications in the enteric nervous system of JF1 mice with the classic piebald mutation. J. Vet. Med. Sci.

21. Dang, R., Torigoe, D., Sasaki, N. and Agui, T. （2012）Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background . Biomed Res.33(4):249-53.