Lu Deng

　　 　　

1. Information

Lu Deng, male, born in January 1989, Jiangxi Shangrao. PhD, Associate Professor of School of Animal Science and Technology, Northwest A&F University, PhD supervisor. Shanghai Young Science and Technology Talent, "Young Talent Program" and "Young Top Talent B1 Post"of Northwest A&F University.

2. Education

2012.09-2017.07   East China Normal University, Biochemistry and

Molecular Biology, PhD

2008.09-2012.07   Jiangxi Normal University, Biotechnology, Bachelor

3. Work Experience

2019.05-to date    Associate Professor, College of Animal Science and Technology,

Northwest A&F University

2017.07-2019.05   Associate Researcher, Tenth People's Hospital, Tongji University

4. Main Research Direction

Insisting on efficient milk production and healthy breeding, aiming to improve the efficiency of lactose synthesis, focusing on the molecular nutritional regulatory network of liver gluconeogenesis in dairy cows, dissecting the important functions of the mTOR pathway in response to nutrients in dairy cattle diets; tapping nutritional targets regulating liver gluconeogenesis in dairy cows; establishing a theoretical system of gastrointestinal microbial-host interactions to modulate the efficiency of gluconeogenic synthesis; and developing nutritional regulation strategies to effectively enhance liver gluconeogenesis and milk production efficiency in dairy cows.

5. Chaired Project

1) Project Source: National Natural Science Foundation of China General Program; Number: 32070782; Start and end time: 2021.01-2024.12; Amount: 58 million.

2) Project Source: National Natural Science Foundation of China Youth Program; Number: 31801177; Start and end time: 2019.01-2021.12; Amount: 26 million.

3) Project Source: "Young Talent Program" of Northwest A&F University; Number: Z111021906; Start and end time: 2019.09-2025.09; Amount: 100 million.

4) Project Source: Guangdong Basic and Applied Basic Research Foundation; Number: 2021A1515220036; Start and end time: 2021.11-2024.10; Amount: 20 million.

5) Project Source: Shanghai Young Science and Technology Talent Sailing Program; Number: 18YF1419500; Start and end time: 2019.01-2021.12; Amount: 20 million.

6) Project Source: Dayu Biotechnology (Xi'an) Industrial Development Research Institute; Number: DYSW2021-001; Start and end time: 2021.09-2022.08; Amount: 7.5 million.

7) Project Source: Northwest A&F University "Special Fund for Basic Scientific Research Business Funds of College of Animal Science and Technology"; Number: DK202102; Start and end time: 2021.06-2022.06; Amount: 6 million.

8) Project Source: Tongji University "Special Fund for Basic Scientific Research Business Funds of Central Universities"; Number: 22120180043; Start and end time: 2018.01-2019.12; Amount: 3 million.

9) Project Source: Shanghai Tenth People's Hospital Municipal and Ministerial Youth Talent Training Program; Start and end time: 2018.9.1-2020.8.31; Amount: 20 million.

10) Project Source: Shanghai Tenth People's Hospital "National Natural Science Foundation Incubation Grant of China"; Number: SYGZRPY2017026; Start and end time: 2018.10.1-2020.09.30; Amount: 6 million.

6. Publications

Lu Deng^#, Lei Chen^#, et al., Ping Wang*. The ubiquitination of Rheb governs growth factor-induced mTORC1 activation.  Cell Research , 2019, 29, 136-150. (IF: 46.3, Q1, First author)

Lu Deng^#*, Tong Meng^#, Lei Chen^#, Wenyi Wei, Ping Wang*. The Role of Ubiquitination in Tumorigenesis and Targeted Drug Discovery, Signal Transduct Target Ther., 2020, 5(11). DOI:10.1038/s41392-020-0107-0. (IF: 38.1, Q1, First and corresponding author)

Lu Deng^#, Cong Jiang^#, Lei Chen^#, Jiali Jin, Jie Wei, Linlin Zhao, Minghui Chen, Weijuan Pan, Yan Xu, Hongshang Chu, Xinbo Wang, Xin Ge, Dali Li, Lujian Liao, Mingyao Liu, Li Li, and Ping Wang*, The Ubiquitination of RagA GTPase byRNF152 Negatively Regulates mTORC1 Activation.  Molecular Cell  .  2015, 5(58):804-818. (IF: 19.3, Q1, First author)

Senlin Qin#, Guoyan Wang#, Lei Chen, Huijun Geng, Yining Zheng, Chao Xia, Shengru Wu, Junhu Yao*, Lu Deng*, Pharmacological Vitamin C Inhibits mTOR Signaling and Tumor Growth by Degrading Rictor and Inducing HMOX1 Expression,  PLOS Genetics , 2023, Accepted. (IF: 6.0, Q1, Corresponding author)

GuoYan Wang#, Lei Chen#, SenLin Qin, YiNing Zheng, Chao Xia, JunHu Yao, Ping Wang, Lu Deng*, Cystine induced-mTORC2 activation through promoting Sin1 phosphorylation to suppress cancer cell ferroptosis,  Molecular Nutrition & Food research , 2022 Dec;66(23):e2200186. (IF: 6.6, Q1, Corresponding author)

GuoYan Wang#, Lei Chen#, SenLin Qin, HuiJun Geng, Chao Xia, YiNing Zheng, XinJian Lei, Jun Zhang, ShengRu Wu, JunHu Yao*, Lu Deng*, Farnesoid X receptor (FXR) regulates mTORC1 signaling and autophagy by inhibiting SESN2 expression,  Molecular Nutrition & Food research , 2023 Jan 30;e2200517. (IF: 6.6, Q1, Corresponding author)

Guoyan Wang#; Jun Zhang#; Shengru Wu#; Senlin Qin; Yining Zheng; Chao Xia; Huijun Geng; Junhu Yao; Lu Deng*, The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α,  Animal Nutrition , 2022 Aug 8;11:121-131. (IF: 5.3, Q1, Corresponding author)

Chao Xia#, Guoyan Wang#, Lei Chen, Huijun Geng, Junhu Yao, Zhangzhen Bai*, Lu Deng*, Trans-gnetin H isolated from the seeds of Paeonia species induces autophagy via inhibiting mTORC1 signalling through AMPK activation,  Cell Proliferation , 2022 Nov 15;e13360. (IF: 8.8, Q1, Corresponding author)

Guoyan Wang#, Lei Chen#, Senlin Qin, Tingting Zhang, Junhu Yao, Yanglei Yi, Lu Deng*, Mechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of Metabolism and Health,  Advances in Nutrition , 2022 Oct 2;13(5):1882-1900. (IF: 11.6, Q1, Corresponding author)

Yining Zheng#, Guoyan Wang#, Rongnuo Li, Huijun Geng, Xinjian Lei, Lei Chen, Shengru Wu, Junhu Yao*, Lu Deng*, Promotion of intestinal epithelial cell apoptosis by enterotoxigenic Escherichia coli via PKA-mediated inhibition of mTORC1 activation,  Microbes and Infection , 2023 Jan 12;105099. (IF: 9.6, Q1, Corresponding author)

Guoyan Wang#; Senlin Qin#; Yining Zheng; Chao Xia; Pei Zhang; Linxuan Zhang; Junhu Yao; Yanglei Yi*; Lu Deng*, T-2 Toxin Induces Ferroptosis by Increasing Lipid Reactive Oxygen Species (ROS) and Downregulating Solute Carrier Family 7 Member 11 (SLC7A11),  Journal of Agricultural and Food Chemistry , 2021 Dec 29;69(51):15716-15727. (IF:5.9, Q1, Corresponding author)

Xiaodong Chen#, Fang Yan#, Tao Liu#, Yuanling Zhang, Xinyi Li, Mengya Wang, Chenguang Zhang, Xiurong Xu, Lu Deng*, Junhu Yao*, Shengru Wu*, Ruminal Microbiota Determines the High-Fiber Utilization of Ruminants: Evidence from the Ruminal Microbiota Transplant,  Microbiology Spectrum , 2022 Aug 31;10(4):e0044622. (IF:9.0, Q1, Co-corresponding author)

Senlin Qin †, Huijun Geng †, Guoyan Wang, Lei Chen, Chao Xia, Junhu Yao, Zhangzhen Bai*, Lu Deng*, Suffruticosol C-Mediated Autophagy and Cell Cycle Arrest via Inhibition of mTORC1 Signaling,  Nutrients , 2022 Nov 24;14(23):5000. (IF: 6.7, Q1, Corresponding author)

邓 露, 张 俊, 姚军虎。胃肠道-肝脏-乳腺协同调节奶牛乳成分的机制, 动物营养学报 2022, 34(10): 6193-6202.

Zhao Linlin^#, Wang Xinbo^#, Yu Yue^#, Deng Lu, et al., Wang Ping*, OTUB1 suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.  Journal of Biological Chemistry . 2018 Mar 30;293(13):4883-4892. (IF: 5.5, Q2)

Rong Li^#, Jie Wei^#, Cong Jiang^#, Dongmei Liu, Lu Deng, Kai Zhang, and Ping Wang. Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis.  Cancer Research . 2013 Sep 15;73(18):5742-53. (IF: 13.3, Q1)

7. Contact

Postal Address：College of Animal Science and Technology, Northwest Agriculture and Forestry University, Xinong Road 22st, Yangling, Shaanxi, China

Post Code：712100

Telephone：18818275171

E-mail：denglu128128@nwafu.edu.cn