Zhepeng Wang

　　 　　

Zhepeng Wang, PhD (Aug. 26, 2023)

Biographical Information

Position title: Associate Professor of Department of Poultry Science

Institution:College of Animal Science and Technology, Northwest A&F University

Address: No. 22 Xinong Road, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, P.R. China

Email: wangzhepeng-001@163.com

Phone: +8615619295726

My research interest and experience

My research interests focus on identifying key mutations governing quantitative and qualitative traits of poultry and breeding of Lueyang black-boned chickens, a Chinese indigenous chicken for higher growth and egg production. I devoted myself to reveal molecular mechanisms controlling appetite and energy balance in the chickens. In this field I have done much work to identify functional variants regulating expression of CCKAR gene which was closely associated with the satiety and the growth of chicken.I am interested to identify genetic variants affecting development of early follicles and egg production of chickens.Several genes that are involved in recruitment and selectionof early follicles and transmembrane transport of yolk were studied in my lab. In addition to economic traits, I worked on identifying the mutations controlling eggshell color. Through linkage mapping and candidate gene study, we successfully recognized blue egg gene as a retrovirus insertion in 5’flanking region of SLCO1B3. Recently, I am interested to find out causative mutations controlling other eggshell color and to reveal evolution process of the blue egg phenotype of difference birds based on our understanding of the molecular mechanisms.

Education

2008.09-2011.06: PhD-degree in Animal Genetics, Breeding & Reproduction at the China Agricultural University

2003.09-2006.06: M.Sc.degree in Animal Genetics, Breeding & Reproduction atthe China Agricultural University

1999.09-2003.06: B.Sc. degree in Animal Science at the University of Nijmegen at the Inner Mongolia Agricultural University

Academic career

2019.08-2020.08 academic visitor at the Roslin Institute, University of Edinburgh

2016 –Associate Professor at the Department of Poultry Science, College ofAnimal Science and Technology, Northwest A&F University

2013 – 2018Post-doc at the Department of Animal Breeding and Genetics, College of Animal Science and Technology, Northwest A&F University

2011 – 2016Lecturer at the Department of Poultry Science, College of Animal Science and Technology, Northwest A&F University

2006 – 2008Lecturer at the Vocational and Technological College, Inner Mongolia Agricultural University

Teaching

Undergraduate courses: “Poultry Production” and “Poultry Production MOOC”

Post graduate courses: “Cellular Genetics”, “Statistics and Experimental Design for Biology” and “Animal Reproduction Biology”

Funding

2021.01-2025.12, Team leader, Breeding of egg laying Lueyang black-boned chicken (Grant No. WJYJY-2021-3).The goal of this project is to breedegg laying performance ofLueyang black-boned chicken.

2021.01-2022.12, Team leader,Key Research and Development Program of Shaanxi Province (Grant No. 2021NY-028) The goal of this project is to reveal regulatory mechanisms of CCKAR gene on feed conversion efficiency of Lueyang black-boned chicken.

2019.06-2020.12, Team leader, Fundamental Research Funds for the Central Universities(Grant No. 2452019202). The goal of this project is to find out cis element variants and epigenetic modifications regulating expression of CCKAR gene.

2018.01-2019.12, Team leader, Natural Science BasicResearch Plan in Shaanxi Province of China (2018JM3002). The goal of this project is to identify candidate genes affecting development of follicles of Lueyang black-boned chicken by RNA-seq.

2015.01 – 2017.12, Team leader, National Natural Science Foundation ofChina (Grant No. 31401051). The goal of this project is to identify differentially expressed genes related to duck blue egg by comparative transcriptome analysis and advance our understanding of molecular mechanisms underlying the phenotype.

2014.01 – 2016.12, Team leader, Natural Science Basic Research Plan inShaanxi Province of China (grant no. 2014JQ3106).The goal of this project is to elucidate the association of very low-density lipoprotein receptor (VLDLR) haplotypeswith egg production.

2014.01 – 2016.01, Team leader, China Postdoctoral Science Foundation (Grant No.2015T81060). The goal of this project is to map mutation causing duck blue egg by GWAS

2013.01 – 2015.12, Team leader, China Postdoctoral Science Foundation (Grant No.2014M550510). The goal of this project is to analyse the association of expression and sequence variants of organic anion transporting polypeptides with duck blue egg

Publications

1. Chen Q, Huang J, Wang Z*. 2023. Establishment of Quantization Method and Genetic Basis Analysis of Brown Eggshell Color in the Lueyang Black-Boned Chicken. Scientia Agricultura Sinica 2023; 56: In press. (*Correspondence)

   Chen Q, Wang ZP*. A new molecular mechanism supports that blue-greenish egg color evolved independently across chicken breeds. Poultry Science, 2022, 101:102223. (*Correspondence)

   Wang ZP, Reid A, Wilson P, Dunn I. Identification of the Core Promoter and Variants Regulating Chicken CCKAR Expression. Genes, 2022, 13: 1083

   Wang ZP, Zhou WX, He JX, Hu QY, Zhao JY. Association of Levels of Cholecystokinin A Receptor Expression and Sequence Variants with Feed Conversion Efficiency of Lueyang Black-Boned Chicken. Scientia Agricultura Sinica, 2022, 55(22): 4539-4549

   Wang ZP, Zhou WX. Fine mapping of sequence variants associated with body weight of Lueyang black-boned chicken in the CCKAR gene. Poultry Science, 2021, 100:101448

   Wang ZP, Zhou WX, He JX, Hu QY, Zhao JY. Association of Levels of CCKAR Expression and Sequence Variants with Feed Conversion Efficiency of Lueyang black-boned chicken. ScientiaAgriculturaSinica, 2021, 54, In press

   Zhang ZY, Lv XY, Zhao JY, Wang ZP*. Analyzing association of genetic factors with age at the onset of egg laying of Lueyang black-boned chickens at the genomic and FSHR gene levels. Journal of China Agricultural University, 2021, 26, In press (*Correspondence)

   Dang LP, Liu RF, Zhao WY, Zhou WX, Min YN, Wang ZP*. Investigating structural impact of a valine to isoleucine substitution on anti-Müllerian hormone in silico and genetic association of the variant and AMH expression with egg production in chickens. Journal of Integrative Agriculture, 2020, 19:1635-1643 (*Correspondence)

   Dang LP, Zhou WX, Liu RF, Bai Y, Wang ZP*. Estimation of genetic parameters of body weight and egg number traits of Lueyang black-boned chicken. ScientiaAgriculturaSinica, 2020, 53(17):3620-3628 (*Correspondence)

   Zhao WY, Yang RH, Liu RF, Min YN, Wang ZP*. Association of expression and sequence variants of TSHR gene with egg laying performance of Lueyang black-boned chicken. China Poultry, 2019, 41(8): 5-9 (*Correspondence)

   Wang ZP, Meng GH, Bai Y, Liu RF, Su LH. Comparative transcriptome analysis provides clues to molecular mechanisms underlying blue-green eggshell color in the Jinding duck (Anas platyrhynchos). BMC Genomics, 2017, 18: 725

   Wang ZP, Yan CL, Zhang GQ, Meng GH, Du Y, Liu RF. Germinal disc region: an appropriate source for obtaining maternal DNA from eggs. Canadian Journal of Animal Science, 2017, 97: 378-382

   Wang ZP, Meng GH, Li N, Yu MF, Liang XW, Min YN, Liu FZ, Gao YP. The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production. Genetics and Molecular Biology, 2016, 39 (3): 380-391

   Wang ZP, Deng XM, Wang AR, Liu RF. High expression of HMOX1 in blue-shelled chickens is associated with a TG haplotype. Brazilian Journal of Poultry Science, 2015, 17(3): 267-274

   Wang ZP, Gao T, Jiang ZQ, Min YN, Mo JX, Gao YP. Effect of ventilation on distributions, concentrations, and emissions of air pollutants in a manure-belt layer house. The Journal of Applied Poultry Research, 2014, 23(4):763-772

   Wang ZP, Qu LJ, Yao JF, Yang XL, Li GQ, Zhang YY, Li JY, Wang XT, Bai JR, Xu GY, Deng XM, Yang N, Wu CX. An EAV-HP insertion in 5’ flanking region of SLCO1B3 causes blue eggshell in the chicken. PLoS Genetics, 2013, 9(1): e1003183

   Wang ZP, Liu RF, Wang AR. Comparison of HMOX1 expression and enzyme activity in blue-shelled chickens and brown-shelled chickens. Genetics and Molecular Biology, 2013, 36(2): 282-286

   Wang ZP, Liu RF, Wang AR, Li JY, Deng XM. Expression and activity analysis reveal that heme oxygenase (decycling) 1 is associated with blue egg formation. Poultry Science, 2011, 90(4): 836-841