Gaoxue WANG

　　 　　

Dr. WANG Gaoxue

Professor and PI of Aquatic Animal Virus Prevention and Control Team

Supervisor of Master's/DoctoralCandidates, Postdoc mentor

Head of the Department of Aquaculture Sciences

Associate Editor, Aquaculture Research

Academic Editor, International Journal of Molecular Sciences

EDUCATION

PhD 2006, Clinical veterinary medicine, Northwest A&F Universityunder supervision of Prof. Yong Zhang (Member of China Engineering Academy),

BSc 1986, Biological Sciences, Shaanxi Normal University

PROFESSIONAL ACTIVITIES

Member of the Subcommittee 11 on Disease Control in Aquaculture of National Technical Committee 156 on Aquaculture of Standardization Administration of China

Member of the National Teaching Steering Committee for Fishery Specialty, Ministry of Education

Member of the Professional Committee of Fish Diseases, China Society of Fisheries

Member of the Professional Committee of Fishery Medicine, China Society of Fisheries

Reviewer: Aquaculture, Journal of Fish Diseases, ACS Nano, Fish and Shellfish Immunology, Journal of Agricultural and Food Chemistry, Aquaculture Reports, Aquaculture Research, Environmental Science and Pollution Research.

REASEARCH

(1)Application of Nanotechnology in the Basic and Applied Research in Aquaculture

Our team has created a multi-valent or multi-conjugate nanoparticle-based immersion vaccine system for diseases prevention and control such as grass carp reovirus, koi spring viremia of carp virus, flounder iridovirus, and so on. This nano-system achieves 65%-95% immune protection for aquatic animals through a single immersion immunization. Currently, some vaccines have entered the stage of applying for new veterinary drug approvals, with the possibility of obtaining 2-3 new veterinary drug certificates for promotion and application. Building upon this foundation, further research has been conducted on degradable, high-safety, and lower-cost organic nanoparticle carriers.

(2)Innovation and Creation of Natural and GreenAquacultureDrugs

After more than 20 years of research, over 30 species with excellent insecticidal and antiviral activity have been selected from more than 800 traditional Chinese medicinal herbs. More than 20 active molecules, including sanguinarine, arctigenin, berberine, and magnolol, have been isolated and identified. Organic chemistry synthesis methods have been used to study the structure-activity relationship of these anti-parasitic/virusmolecules, resulting in a series of novel coumarin and lignin derivatives, laying the foundation for the transformation and application for national veterinary drug raw materials. Recently, various active molecules' drug target has been identified using omics techniques, revealing their mechanisms of action. This provides a scientific basis for the application and promotion of new raw materials for anti-parasitic/anti-virus drugs in aquaculture.

(3)Biotechnological Breeding of Disease-resistant Aquatic Animal Seedlings

Targeting important aquatic pathogens such as grass carp reovirus (GCRV), spring viremia of carp virus (SVCV), white spot syndrome virus (WSSV), and nervous necrosis virus (NNV), a multi-target nanoparticle drug delivery system was developed in conjunction with inorganic nanoparticle carriers and virus-targeted drug delivery technology. This system achieves a killing efficiency of 90%-100% against aquatic viruses through a single immersion method, resulting in an increase of 50%-90% or more in the survival rate of aquatic animals. Combined with the state of the art in CRISPR/Cas system, new disease resistant fish species will be create.This research provides a theoretical and technical foundation for the healthy development of the aquatic animal disease-resistant vaccine and biological breeding industry in the future.

RESEARCH GRANTS

Principal Investigator

1. 2022.01-2025.12 Chinese National Natural Science Foundation (Grant No. 32273180）

2. 2018.01-2021.12 Joint Funds of the National Natural Science Foundation of China (Grant No. U1701233)

3. 2018.01-2021.12 Chinese National Natural Science Foundation (Grant No. 31772873）

4. 2014.01-2017.12 Chinese National Natural Science Foundation (Grant No. 31372559）

5. 2013.01-2013.12 Chinese National Natural Science Foundation (Grant No. 31272693）

6. 2011.01-2013.12 Chinese National Natural Science Foundation (Grant No. 31072242）

7. 2013.01-2013.12 Key project of Agricultural Science and Technology of Shaanxi Province (Grant No. 2010K02-09-3)

8. 2013.01-2013.12 National Spark Program (Grant No. 2013211)

9. 2015.01-2017.12 Key project of Department of Science, Technology and Water Resources of Shaanxi Province. (Grant No. 2016slkj-18)

TEACHING ACTIVITIES

Undergraduate course:Aquatic Animal Disease Control; Freshman Seminar Course

Graduate course: Research ProgressAquatic Animal Disease Control

PUBLICATIONS

Authored or co-authored in more than 220 journal articles, conference papers and chapters in books, of which more than 90 articles were published in JCR Q1 journal, 2 articles were selected as ESI Highly Cited Paper. 26 filed patents.

Representative publications:

[1] Wang EL*, Zhou Y*, Liang Y, Ling F, Xue XS, He XL,Zhai XL, Xue Y, Zhou CL, Tang G, Wang GX*. Rice flowering improves the muscle nutrient, intestinal microbiota diversity, and liver metabolism profiles of tilapia (Oreochromis niloticus) in rice-fish symbiosis. Microbiome 2022; 10: 231.

[2]Ling F, Steinel N, Weber J, Ma L, Smith C, Correa D, Zhu B, Bolnick D*, Wang GX*. The gut microbiota response to helminth infection depends on host sex and genotype. ISME J., 2020, 14:1141-53.

[3] Song KG, Luo F, Chen WC, Qi XZ, Shen YF, Zha JW, Ling F*,Wang GX*. Evaluation on the antiviral activity of Bacillus velezensis extract against spring viremia of carp virus[J]. Aquaculture, 2022, 547: 737477.

[4]Liu GY, Li J, Zhang ZY, Liu JY, Zhang C, Zhu B*, Wang GX*. An immersion subunit vaccine loaded by single-walled carbon nanotube protects pearl gentian grouper from viral nervous necrosis virus[J]. Aquaculture, 2021, 541: 736813.

[5] Tu X, Tan XP, Qi XZ, Huang AG, Ling F*, Wang GX*. Proteome interrogation using gold nanoprobes to identify targets of arctigenin in fish parasites. J. Nanobiotechnology, 2020, 18:32.

[6] 33.Zhang YL, Tan XP, Tu X, Ling F*, Wang GX*. Efficacy and antiparasitic mechanism of curdione from Curcuma zedoaria against Gyrodactylus kobayashii in goldfish. Aquaculture, 2020, 523.

[7] Hu Y, Shen YF, Wu XH,Tu X, Wang GX*. Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. European Journal of Medicinal Chemistry. 2018, 143: 958-969.

CONTACT

Office: College of Animal Science and Technology Building, Room 136

Email: wanggaoxue@126.com

Phone (WeChat):0086 131 8602 6258