LEI ZHANG

　　 　　

LEI ZHANG

College of Animal Science & Technology

Northwest A&F University

Xinong Rd. 22#

712100Yangling

China

E-mail: zhanglei07dongke@163.com

Higher education

2014.09-2017.12

Doctor,Animal genetic breeding and reproduction

College of Animal Science and Technology

Northwest A&F University, P.R.China

2011.09-2014.06

Master, Animal genetic breeding and reproduction

College of Animal Science and Technology

Northwest A&F University, P.R.China

2007.09-2011.06

Bachelor, Animal Science

College of Life Sciences and Engineering

Northwest Minzu University, P.R.China

Research interests

Committed to the breeding and management of new varieties of dairy sheep, as well as the research, development, and promotion of key technologies for efficient reproduction.

Research experience

2020.10-present  Associate research fellow, Northwest A&F University, China

2018.08-2020.09  Research assistant, Northwest A&F University, China 

Selected publications

Ran Li, Mian Gong, Xinmiao Zhang, Fei Wang, Zhenyu Liu, Lei Zhang et al. A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes. Genome Research.2023,33(3):463-477.

Wang Zhanhang, He Yonglong, Liu Shujuan, Xu Xiaolong, Song Yuxuan, Zhang Lei, An Xiaopeng.Toxic effects of zinc oxide nanoparticles as a food additive in goat mammary epithelial cells. Food Research International, 2023, 167:112682.

Li Danni, Zhang Lei, Wang Yuchen, Chen Xingzhuo, Li Fu, Yang Lichun, Cui Jiuzeng, Li Ran, Cao Binyun, An Xiaopeng, Song Yuxuan.FecB mutation and litter size are associated with a 90-base pair deletion in BMPR1B in East Friesian and Hu crossbred sheep. Animal Biotechnology.2023,34(4):1314-1323.

Zhang L, Liu X, Che S, Cui J, Ma X, An X, Cao B, Song Y. Endometrial Epithelial Cell Apoptosis Is Inhibited by a ciR8073-miR181a-Neurotensis Pathway during Embryo Implantation. Mol Ther Nucleic Acids. 2019,14:262-273.

Liu Xiaorui , Zhang Lei *, Cui Jiuzeng , Yang Lichun , Han Jin cheng , Che Sicheng , Cao Binyun, Li Guang, Song Yuxuan. CircRNA landscape of non-pregnant endometrium during the estrus cycle in dairy goats. Journal of Integrative Agriculture.2021, 20(5): 1346–1358

Liu Xiaorui, Zhang, Lei, Yang Lichun, Cui Jiuzeng, Che Sicheng, Liu Yuexia, Han Jincheng, An Xiaopeng, Cao Binyun, Song, Yuxuan. miR-34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ-8073/CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/ mTOR pathways. JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235(12): 10051-10067.

Cui Jiuzeng, Liu Xiaorui, Yang Lichun, Che Sicheng, Guo Hongran, Han Jincheng, Zhu Zhongshi, Cao Binyun, An Xiaopeng, Zhang Lei, Song, Yuxuan. MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway. GENES, 2020, 11(9):1052.

Song Yuxuan; Zhang Lei; Liu Xiaorui; Niu Mengxiao; Cui Jiuzeng; Che Sicheng; Liu Yuexia; An Xiaopeng; Cao Binyun. Analyses of circRNA profiling during the development from prereceptive to receptive phases in the goat endometrium, JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2019, 10(03): 633-647.

Zhang, Lei; Liu, Xiaorui; Cui, Jiuzeng; Che, Sicheng; Liu, Yuexia; An, Xiaopeng; Cao, Binyun; Song, Yuxuan. LncRNA882 regulates leukemia inhibitory factor (LIF) by sponging miR‐15b in the endometrial epithelium cells of dairy goat. Journal of Cellular Physiology, 2018, DOI: 10.1002/jcp.27272.

Zhang L, Liu X, Che S, Cui J, Liu Y, An X , Cao B, Song Y. CircRNA-9119 regulates the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) by sponging miR-26a in the endometrial epithelial cells of dairy goat. Reproduction, Fertility, and Development, 2018, DOI: 10.1071/RD18074.

Zhang L, Liu X, Ma X, Liu Y, Che S, Cui J, An X, Cao B, Song Y*. Testin was regulated by circRNA3175-miR182 and inhibited endometrial epithelial cell apoptosis in pre-receptive endometrium of dairy goats. Journal of Cellular Physiology, 2017, doi: 10.1002/jcp.26614

L. Zhang#, X. R. Liu#, J. Z. Liu, X. P. An, Z. Q. Zhou, B. Y. Cao, Y. X. Song*. Supplemented Organic and Inorganic Selenium Affects Milk Performance and Selenium Concentration in Milk and Tissues in the Guanzhong Dairy Goat. Biol Trace Elem Res, 2017, DOI 10.1007/s12011-017-1112-1.

Xiao-Peng An#, Xiao-Rui Liu#, Lei Zhang#, Junze Liu, Xinyan Zhao, Kaiwen Chen, Haidong Ma, Guang Li, Yuxuan Song*. MiR-449a regulates caprine endometrial stromal cell apoptosis and endometrial receptivity. Scientific reports. 2017, DOI:10.1038/s41598-017-12451-y

Song Y#, An X#, Zhang L#, Fu M, Peng J, Han P, Hou J, Zhou Z, Cao B*. Identification and Profiling of microRNAs in Goat Endometrium during Embryo Implantation. PloS one, 2015, 10(4) :e0122202, DOI:10.1371/journal.pone.0122202.

Patent

Zhang Lei, Song Yuxuan, An Xiaopeng, Zhang Xiyun, Zhou Yong, Zhan Jianhua, Zhu Wanbin, Ma Zhongming, Guo Lei, Du Shuzeng. 2023. A method for improving the lactation ability of dairy sheep. CN114375907B[P], issued March 21, 2023.

Zhang Lei, Song Yuxuan, Liu Xiaorui, Zhang Xiyun, An Xiaopeng, Zhou Yong, Guo Lei,Zhan Jianhua, ZhaoPengshan, ZhuWanbin. 2022. A new breed method for dairy sheep. CN114391508B[P], issued October 21, 2022.

Zhang Lei, Song Yuxuan, Sun Yaojun, Wang Qiang, Liu Xiaorui, Cui Jiuzeng, Zhou Zhanqin. 2023. The utility model relates to an environmentally friendly sheep manure recycling fermentation treatment device. CN218811436U[P], issued April 7, 2023.

Zhang Lei, Song Yuxuan, Liu Xiaorui, Wang Bin, Fu Mingzhe. 2021. A dairy sheep artificial insemination guarantee frame. CN215307021U[P], issued December 28, 2021.

Zhang Lei, Song Yuxuan, Liu Xiaorui, Zhang Xiyun, Fu Mingzhe, Wang Bin. 2021. A dairy sheep embryo transfer rack. CN214857818U[P], issued November 26, 2021.

International oral presentations

Development of dairy sheep industry and breeding progress, The third "Leader Program" academic practice exchange meeting and University alliance annual meeting, 2022, Tencent Conference

Endometrial Epithelial Cell Apoptosis Is Inhibited by a ciR8073-miR181a-Neurotensis Pathway during Embryo Implantation, China Herbivore Science and Technology Conference, 2021, Changchun, China