Ningbo Chen, Ph.D.
Current Position: Associate Professor at College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100 China
E-mail: ningbochen@nwafu.edu.cn;
ACADEMIC FORMATION
June 2019. Ph.D. degree in Animal genetics and breeding, Northwest A&F University.
July 2019. Associate Professor, College of Animal Science and Technology Northwest A&F University.
Aug 2020-Jan 2024. Postdoctoral Fellow, College of Animal Science and Technology Northwest A&F University.
RESEARCH AREA
Cattle Population Omics/ Bovine Genetics/ Molecular Evolution/ Bioinformatics/
My research provides fundamental insight into the origin of cattle, genome organization and plasticity of farm animals, thereby improving our understanding of the molecular-genetic underpinnings of complex traits and diseases. Focus on to dissect genetic architecture of bovine populations, including cattle, yak, and other wild bovine species, quantitatively characterize their admixture features, and reveal their migration history and adaptive divergence. Using next generation sequencing, mitochondrial and the nuclear genome of both ancient and modern bovine species to reveal the population evolution and adaptive introgression.
The four main research goals include:
[1]genome assembly and pangenome integration of Chinese cattle,
[2]the origin and formation of East Asian bovine species, including cattle, yak, aurochs, using ancient and modern DNA technology,
[3]the genetic characterization of cattle adaptation to extremely environments, and
[4]population-scale complex trait genomics using omics data.
EDITORIAL AND REVIEWER ACTIVITY
Editorial Board of
BMC Biology, Genomics Proteomics Bioinformatics, BMC Genomics, BMC Genomic Data, Journal of Integrative Agriculture, Journal of Genetics and Genomics, Animal Research and One Health.
The reviewer activity carried out refers to
Genome Biology, PNAS, iScience, Journal of Animal Breeding and Genetics, Animal Genetics, Genetic Selection Evolution, BMC Ecology and Evolution, Journal of Archaeological Science: Reports.
AWARDS
2020 Technology New Star in Shaanxi province, China
2020 Reward-gainers of the excellent PhD dissertations in Shaanxi Province, China
2023 Travel Bursary Award, 2023 ISAG Conference
2023 Best Poster Presentation, 2023, GPB Omics & Bioinformatics Frontiers Symposium
PUBLICATIONS
Selected publications from peer-reviewed journals, * stands for Corresponding author, # stands for Co-first author.
[1]Shungang Chen *, Lele Ren, Yu Gao, Guanghui Dong, Guilian Sheng, Jianlin Han, Xinyi Liu, Ningbo Chen*, Fahu Chen. (2024) Evidence of hybridization of cattle and aurochs on the Tibetan Plateau ~3750 years ago. Science Bulletin.【IF=18.8】
[2]Yang Lyu#, Fuwen Wang#, Haijian Cheng#, Jing Han#, Ruihua Dang#, Xiaoting Xia#, Hui Wang, Jincheng Zhong, Johannes A. Lenstra, Hucai Zhang, Jianlin Han, David MacHugh, Ivica Medugorac, Maulik Upadhyay, Alexander S Leonard, He Ding, Xiaorui Yang, Mingshan Wang, Suolang Quji, Basang Zhuzha, Pubu Quzhenp, Silang Wangmu, Nima Cangjue, Da Wa, Weidong Ma, Jianyong Liu, Jicai Zhang, Bizhi Huang, Xingshan Qi , Fuqiang Li , Yongzhen Huang, Yun Ma , Yu Wang, Yuanpeng Gao*, Wenfa Lu*, Chuzhao Lei*, Ningbo Chen*. (2024). Recent selection and adaptive introgression facilitated high-altitude adaptation of Qinghai-Tibetan Plateau cattle Science Bulletinhttps://doi.org/10.1016/j.scib.2024.05.030【IF=18.8】
[3]Ningbo Chen#, Xiaoting Xia#, Quratulain Hanif#, Fengwei Zhang#, Ruihua Dang#, Bizhi Huang#, Yang Lyu, Xiaoyu Luo, Hucai Zhang, Shikang Wang, Fuwen Wang, Jialei Chen, Xiwen Guan, Yangkai Liu, Shuang Li, Liangliang Jin, Pengfei Wang, Luyang Sun, Haijian Cheng, Jicai Zhang, Jianyong Liu, Kaixing Qu, Yanhong Cao, Junli Sun, Yuying Liao, Zhengzhong Xiao, Ming Cai,Lan Mu, AMAM Zonaed Siddiki, Muhammad Asif, Shahid Mansoor, Masroor Ellahi Babar, Tanveer Hussain, Gamamada Liyanage Lalanie Pradeepa Silva, Neena Amatya Gorkhali, Endashaw Terefe,, Gurja Belay, Abdulfatai Tijjani, Tsadkan Zegeye, Mebrate Genet Gebre, Yun Ma, Yu Wang, Yongzhen Huang, Xianyong Lan, Hong Chen, Nicola Rambaldi Migliore, Giulia Colombo, Ornella Semino, Alessandro Achilli, Mikkel-Holger S Sinding, Johannes A Lenstra, Olivier Hanotte*, Jianlin Han*, Yu Jiang*, Chuzhao Lei*. (2023) Global genetic diversity, introgression and evolutionary adaptation of indicine cattle revealed by whole genome sequencing. Nature Communications. 14, 7803.【IF=14.7】
[4]Ningbo Chen#, Zhengwei Zhang#, Jiawen Ho#, Jialei Chen#, Xuan Gao, Li Tang, Shargan Wangdue, Xiaoming Zhang, Mikkel-Holger S Sinding, Xuexue Liu, Jianlin Han, Hongliang Lü*, Chuzhao Lei*,
Fiona Marshall* and Xinyi Liu*. (2023) Evidence for early domestic yak, taurine cattle, and their hybrids on the Tibetan Plateau. Science Advances. 9, eadi6857.【IF=11.7】
[5]Xiaoting Xia, Fengwei Zhang, Shuang Li, Xiaoyu Luo, Lixin Peng, Zheng Dong, Hubert Pausch, Alexander S. Leonard, Danang Crysnanto, Shikang Wang, Bin Tong, Johannes A. Lenstra, Jianlin Han, Fuyong Li, Tieshan Xu, Lihong Gu, Liangliang Jin, Ruihua Dang, Yongzhen Huang, Xianyong Lan, Gang Ren, Yu Wang, Yuanpeng Gao, Zhijie Ma, Haijian Cheng, Yun Ma, Hong Chen, Weijun Pang*, Chuzhao Lei*, Ningbo Chen* (2023) Structural variation and introgression from wild populations in East Asian cattle genomes confer adaptation to local environment. Genome Biology. 24, 211.【IF=10.1】
[6]Chen, Ningbo#; Ren, Lele#; Du, Linyao#; Hou, Jiawen#; Mullin, VictoriaE.; Wu, Duo; Zhao, Xueye; Li, Chunmei; Huang, Jiahui; Qi, Xuebin; Capodiferro, Marco Rosario; Achilli, Alessandro; Lei, Chuzhao; Chen, Fahu; Su, Bing*; Dong, Guanghui*; Zhang, Xiaoming*. (2020) Ancient genomes reveal tropical bovid species in the Tibetan Plateau contributed to the prevalence of hunting game until the late Neolithic. Proceedings of the National Academy of Sciences, 2020, 117(45): 28150-28159. 【IF=11.205】
[7]Chen Ningbo#; Cai Yudong#; Chen Qiuming#; Li Ran#; Wang Kun#; Huang Yongzhen#; Hu Songmei; Huang Shisheng; Zhang Hucai; Zheng Zhuqing; Song Weining; Ma Zhijie; Ma Yun; Dang Ruihua; Zhang Zijing; Xu Lei; Jia Yutang; Liu Shanzhai; Yue Xiangpeng; Deng Weidong; Zhang Xiaoming; Sun Zhouyong; Lan Xianyong; Han Jianlin; Chen Hong; Bradley Daniel G; Jiang Yu*; Lei Chuzhao*. (2018) Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia. Nature Communications 9.【IF=14.7】
[8]Chen, Ningbo#; Fu, Weiwei#; Zhao, Jianbang; Shen, Jiafei; Chen, Qiuming; Zheng, Zhuqing; Chen, Hong; Sonstegard, Tad S.; Lei, Chuzhao; Jiang, Yu*. (2020) BGVD: Integrated Web-database for Bovine Sequencing Variations and Selective Signatures. Genomics, Proteomics & Bioinformatics. 2020, 18(2): 186-193.【IF=11.5】
[9]Ningbo Chen, Artem Nedoluzhko. (2023) Ancient DNA: the past for the future. BMC Genomics 2023 24:309.【IF=4.4】
[10]Yang Lyu, Yaxuan Ren, Kaixing Qu, Suolang Quji, Basang Zhuzha, Chuzhao Lei*, Ningbo Chen* (2023) Local ancestry and selection in admixed Sanjiang cattle. Stress Biology. 3:30.
[11]Fengwei Zhang#, Chong Wang#, Haiyue Xu#, Xiaoting Xia, Xiaoyu Luo, Kaihui Li, Jianlin Han, Chuzhao Lei*, Ningbo Chen*, Xiangpeng Yue*. (2023) Genomic analysis reveals a KIT-related chromosomal translocation associated with the white coat phenotype in yak. Journal of Animal Breeding and Genetics. 140(3):330-342.【IF=3.271】
[12]Xiaoting Xia, Kaixing Qu, Yan Wang, Mikkel‑Holger S. Sinding, Fuwen Wang, Quratulain Hanif, Zulfqar Ahmed, Johannes A. Lenstra, Jianlin Han, Chuzhao Lei* and Ningbo Chen*. (2023) Global dispersal and adaptive evolution of domestic cattle: a genomic perspective. Stress Biology. 3:8.
[13]Yuqing Han#, Lulan Zeng#, Shuang Li, Gaoxiang Yuan, Ying Liu, Xuhong Ding, Kaixing Qu, Fuqiang Li, Jicai Zhang, Chuzhao Le, Bizhi Huang*, Ningbo Chen*. (2021) T2R12 gene variation in Chinese native cattle owing to banteng introgression. Animal Genetics,52(4):565-566. 【IF=3.169】
[14]Xiao-Ting Xia, Alessandro Achilli, Johannes A. Lenstra, Bin Tong, Yun Ma, Yong-Zhen Huang, Jian-Lin Han, Zhou-Yong Sun, Hong Chen, Chu-Zhao Lei1, Song-Mei Hu*, Ning-Bo Chen*. (2021) Mitochondrial genomes from modern and ancient Turano-Mongolian cattle reveal an ancient diversity of taurine maternal lineages in East Asia. Heredity, 126(6):100-1008.【IF=3.821】
[15]Chen Ningbo#; Huang Jieping#; Zulfiqar Abbasi; Li Ran; Xi Yulian; Zhang Mingming; Dang Ruihua; Lan Xianyong; Chen Hong; Ma Yun; Lei Chuzhao*. (2018) Population structure and ancestry of Qinchuan cattle. Animal Genetics 49, 246-8. 【IF=1.841】
PRESENTATIONS
[1]Recent selection and introgression facilitated high-altitude adaptation in cattle, PAG Asia (Shenzhen, 2024)；
[2]Structural Variations in East Asian Cattle, PAG Asia (Shenzhen, 2024)；
[3]Structural Variation and Wild Introgression in East Asian Cattle, PAG Australia (Perth, 2023)；
[4]History and unique evolutionary adaptation of indicine cattle, PAG Australia (Perth, 2023)；
[5]Genomics landscape of Chinese cattle PAG Online Conference, June 24, 2022
The tropical and Subtropical Adaptation and Genetic Diversity of Chinese Local Cattle Based on the Whole Genome Data Shenzhen PAG June 7, 2019
