JiangWei Wu

　　 　　

Jiang Wei Wu, Ph.D.

Professor of Northwest A&F University

OFFICE

•College of Animal Science and Technology　3 Taicheng, Road, Yangling, Shaanxi Province, China, 712100

CONTACT INFORMATION

Email wujiangwei@nwafu.edu.cn

Bio

Dr. Wu received her PhD degree from Northwest A&F University in China and conducted joint training at Montreal University in Canada. She continued her research as a postdoctoral fellow at Montreal University, followed by a research assistant residency there. Then, Dr. Wu became an independent principal investigator at Northwest A&F University in Chinaas a full professor. She was selected as a nationalyoung talent and has been awarded the National Excellent Doctoral Thesis, Shaanxi Youth Science and Technology Award, Shaanxi Youth Science and Technology pacesetter, etc. She is an excellent and respected researcher in the field of glucose and lipid metabolism.

RESEARCH FOCUS

•Disorder of glucose and lipid metabolism (obesity, fatty liver etc.)

•Depot specific fat accumulation and muscle development in preclinical model pigs

•Generation of gene modified pigs for xenotransplantation and human diseases

PROFESSIONAL EDUCATION

•Bachelor of Animal Science, Northwest A&F University, China (1999-2003)

•Master’s Degree in Animal Breeding and Genetics, Northwest A&F University, China (2003-2006)

•PhDin Zoology, Northwest A&F University, China(2006-2011)

•Joint PhD training, Montreal University, Canada(2008-2011)

•Research assistant,Montreal University, Canada (2011-2012)

•Postdoctoral researcher,Montreal University, Canada (2012-2016)

•Professor, Northwest A&F University, China (2016-present)

FUNDINGS

•National Natural Science Foundation of China, Exploration of the mechanism underlying ASGR1 deficiency-induced liver injury from the perspective of endoplasmic reticulum stress, 32370569,2024-2027

•National Key Research and Development Program of China, Molecular regulatory network for the formation of high-yield, high-quality, high-efficiency traits in pigs, 2021YFF1000602, 2021-2026

•National Natural Science Foundation of China, Generation of asialoglycoprotein receptor 1 (ASGR1) gene knockout pigmodel for human atherosclerosis using CRISPR-Cas9 gene editingtechnique, 32070602, 2021-2024

•National Key Research and Development Program of China, The Regulation and Mechanism of Dietary Composition and Feeding System on the Formation of Healthy and High-Quality Meat in Livestock and Poultry, 2018YFD0500402-3,2018-2020

•Innovation Capability Support Plan of Shaanxi Science and Technology Department, Muscle Biology and Porcine Genetic Improvement Innovation Group, 2023-CX-TD-57, 2023-2025

•Shaanxi Provincial Key Research Program, The role and mechanism of transcription factor ZBED6 in regulating the growth and development of porcine skeletal muscle, 2020NY-012, 2020-2021

•Oversea High-Level Talent Recruitment Programs, The Role and Regulatory Mechanism of Lipid Metabolism in Intramuscular Fat Deposition and Muscle Development in Animals, 2016-2021

HONORS AND AWARDS

•International Excellent Postdoctoral Fellowships in Canada (2012)

•Postdoctoral Fellowship of the Medical Foundation of Quebec, Canada (2012)

•Excellent Doctoral Dissertation in China (2014)

•Innovative leading talents in science and technology from Shaanxi Province (2017)

•Shaanxi youth science and technology pacesetter (2018)

•The 12th Shaanxi Youth Science and Technology Award (2018)

SELECTED PUBLICATIONS

•Loss ofZBED6ProtectsAgainstSepsis-Induced MuscleAtrophy byUpregulatingDOCK3-MediatedRAC1/PI3K/AKTSignalingPathway inPigs.Huan Liu, Dengke Pan, Pu Li, Dandan Wang, Bo Xia, Ruxin Zhang, Junfeng lu, Xiangyang Xing, Jiaxiang Du, Xiao Zhang, Long Jin, Lin Jiang*, Linong Yao*, Mingzhou Li*, Jiangwei Wu *. Advanced Science. 2023, Aug 07.

•Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver. Luxi Chen#, Jing Li#, Renqiang Yuan#, Yujie Wang#, Jiaman Zhang#, Yu Lin#, Lina Wang, Xingxing Zhu, Wei Zhu, Jingyi Bai, Fanli Kong, Bo Zeng, Lu Lu, Jideng Ma, Keren Long, Long Jin, Zhiqing Huang, Jinlong Huo, Yiren Gu, Danyang Wang, Delin Mo, Diyan Li, Qianzi Tang, Xuewei Li,Jiangwei Wu*, Yaosheng Chen*, Mingzhou Li*. Cell Discovery.2022 Jun 14.

•Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β. Xiao Chen Shi#, Bo Xia#, Jian Feng Zhang, Rui Xin Zhang, Dan Yang Zhang, Huan Liu, Bao Cai Xie, Yong Liang Wang*, Jiang Wei Wu*.PLOS Biology.2022 Apr 27.

•Camptothecin effectively treats obesity in mice through GDF15 induction.Jun Feng Lu#, Meng Qing Zhu#, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Rui Xin Zhang, Bo Xia,Jiang Wei Wu*.PLOS Biology.2022 Feb 24.

•Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.Bo Xia#, Xiao Chen Shi#, Bao Cai Xie#, Meng Qing Zhu, Yan Chen, Xin Yi Chu, Guo He Cai, Min Liu, Shi Zhen Yang, Grant A. Mitchell, Wei Jun Pang*,Jiang Wei Wu*.PLOS Biology.2020 Mar 27.

•AdipoRon exerts opposing effects on insulin sensitivity via fibroblast growth factor 21–mediated time-dependent mechanisms. Yongliang Wang, Huan Liu, Ruixin Zhang, Yuyao Xiang, Junfeng Lu, Bo Xia*, Liang Peng*,Jiangwei Wu*. Journal of Biological Chemistry.2022 Jan 25.

•Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets. Dandan Wang#, Denke Pan#, Baocai Xie#, Shengnan Wang, Xiangyang Xing, Xuexue Liu, Yuehui Ma, Leif Andersson,Jiangwei Wu*, Lin Jiang*.PLOS Genetics. 2021 Oct 28.

•Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans.Bao Cai Xie#, Xiao Chen Shi#, Yan Li#, Bo Xia, Jia Zhou, Minjie Du, Xiangyang Xing, Liang Bai, Enqi Liu, Fernando Alvarez, Long Jin, Shaoping Deng, Grant A. Mitchell, Dengke Pan*, Mingzhou Li*,Jiangwei Wu*. PLOS Genetics. 2021 Nov 11.

•Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.Jiang Wei Wu*#, Christoph Preuss#, Shu Pei Wang, Hao Yang, Bo Ji, Gregory W. Carter, Rebecca Gladdy, Gregor Andelfinger*, Grant A. Mitchell*. PLOS Genetics.2017 May 1.

•Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice. Bo Xia#, Guo He Cai#, Hao Yang, Shu Pei Wang, Grant A. Mitchell*, Jiang Wei Wu*.PLOS Genetics.2017 Dec 12.

•Potential Mechanism Underlying the PNPLA3I148M-Hepatic Steatosis Connection.Jiang Wei Wu, Hao Yang, Grant A. Mitchell*.Hepatology.2015 Jun 19.

•Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis.Jiang Wei Wu,Shu Pei Wang, Fernando Alvarez, Stéphanie Casavant, Nicolas Gauthier, Lynda Abed, Krishnakant G. Soni, Gongshe Yang*, Grant A. Mitchell*.Hepatology.2011 Apr 04.

•Diosmetin Protects Against Obesity and Metabolic Dysfunctions Through Activation of Adipose Estrogen Receptors in Mice.Baocai Xie#, Dengke Pan#, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu*.Molecular Nutrition & Food Research.2021 Jul 05.

•Protocatechuic acid ameliorates high fat diet-induced obesity and insulin resistance in mice. Yuyao Xiang#, Ruolan Huang#, Yongliang Wang#, Shanshan Han#, Xiaochen Qin#, Zhenzhen Li, Xu Wang, Yuqing Han, Tao Wang, Bo Xia, Jiangwei Wu, Gongshe Yang*. Molecular Nutrition & Food Research.2022 October 14.

•Impacts of Selected Dietary Nutrient Intakes on Skeletal Muscle Insulin Sensitivity and Applications to Early Prevention of Type 2 Diabetes.Xin Zhang, Doudou Xu, Meixia Chen, Yubo Wang, Linjuan He, Lu Wang, Jiangwei Wu, Jingdong Yin*.Advances in Nutrition.2021 Jan 8.

•Identification of Dacinostat as a potential anti-obesity compound through transcriptional activation of adipose thermogenesis in mice.Xin Yi Chu#, Cong Cong Zhang#, Rui Xin Zhang, Jian Feng Zhang, Bo Xia, Jiang Wei Wu*.BBA-Molecular Basis of Disease.2021 May 15.

•Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high-fat diet-fed mice.Jun Feng Lu#, Meng Qing Zhu#, Heng Zhang, Hao Liu, Bo Xia, Yong Liang Wang, Xin’e Shi, Liang Peng*,Jiang Wei Wu*.The FASEB Journal.2020 Jul 30.

•Mitochondrial aconitase controls adipogenesis through mediation of cellular ATP production.Yan Chen#, Guo He Cai#, Bo Xia, Xin Wang, Cong Cong Zhang, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Jun Feng Lu, Rui Xin Zhang, Meng Qing Zhu, Min Liu, Shi Zhen Yang, Dan Yang Zhang, Xin Yi Chu, Rajwali Khan, Yong Liang Wang, Jiang Wei Wu*.The FASEB Journal.2020 Mar 24.

•Isorhapontigenin Improves Diabetes in Mice via Regulating the Activity and Stability of PPARgamma in Adipocytes.Xin Yi Chu, Shi Zhen Yang, Meng Qing Zhu, Dan Yang Zhang, Xiao Chen Shi, Bo Xia, Ye Yuan, Min Liu, Jiang Wei Wu*. Journal of Agricultural and Food Chemistry.2020 Mar 16.

•A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion.Xin Wang#, Min Liu#, Guo He Cai, Yan Chen, Xiao Chen Shi, Cong Cong Zhang, Bo Xia, Bao Cai Xie, Huan Liu, Rui Xin Zhang, Jun Feng Lu, Meng Qing Zhu, Shi Zhen Yang, Xin Yi Chu, Dan Yang Zhang, Yong Liang Wang, Jiang Wei Wu*.Cells.2020 Jan 31.

•An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis.Xiao Zhang, Cong Cong Zhang, Hao Yang, Krishnakant G. Soni, Shu Pei Wang, Grant A. Mitchell*, Jiang Wei Wu*. Cells.2019 Apr 29.

•Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance.Hao Yang, Jiang Wei Wu, Shu Pei Wang, Ilenia Severi, Loris Sartini, Norma Frizzell, Saverio Cinti, Gongshe Yang*, Grant A. Mitchell*.Diabetes.2012 Dec.

•Inborn errors of cytoplasmic triglyceride metabolism. Jiang Wei Wu, Hao Yang, Shu Pei Wang, Krishnakant G. Soni, Catherine Brunel-Guitton & Grant A. Mitchell*.Journal of Inherited Metabolic Disease.2016 Aug 16.

•Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase.Jiang Wei Wu, Shu Pei Wang, Stéphanie Casavant, Alain Moreau, Gong She Yang, Grant A. Mitchell*.Endocrinology.2012 May 01.