1．基本信息

朱斌，男，1985年12月生，湖北宜昌人，博士，教授，博士生导师。主要从事水产动物病害免疫防控方面的教学和科研工作。入选西北农林科技大学“青年英才计划”、西北农林科技大学“卓越新星”、西北农林科技大学首批“高层次人才发展支持计划”青年拔尖人才。担任《水生生物学报》青年编委、《Microbiology Spectrum》、《Fishes》编委，《Journal of Advanced Research》、《Journal of Virology》、《The Journal of Immunology》、《Vaccine》、《Vaccines》、《Aquaculture》和《Fish & Shellfish Immunology》等期刊审稿人。

2．教育经历

2005年9月-2009年6月，西北农林科技大学动物科技学院，水产养殖学学士

2009年9月-2012年6月，西北农林科技大学动物科技学院，水生生物学硕士

2012年9月-2015年6月，西北农林科技大学动物科技学院，水生生物学博士

3．工作经历

2015年6月-2015年8月，西北农林科技大学动物科技学院，讲师

2015年9月-2021年12月，西北农林科技大学动物科技学院，副教授

2022年1月至今西北农林科技大学动物科技学院，教授

4．研究方向

[1] 水产动物高效疫苗设计及其分子免疫机制；

[2] 水产动物病原抗体诊断与靶向治疗。

5．开设课程与学生培养

承担本科生《水产动物免疫学》、《水产动物病害学实验》和研究生《水产动物病害学研究进展》、《现代渔业进展》、《水产生物疫病综合防技术与应用案例》等课程教学任务。主持课程建设项目3项，参与编写本科和研究生课程教材3部。

指导本科毕业论文21人，荣获校级百篇优秀毕业论文1人，校级优秀毕业论文2人，院级优秀毕业论文7人。指导大学生科创项目9项（国家级3项、省级3项、校级3项），发表SCI论文6篇，获大学生创新创业论坛特等奖、全国大学生生命科学竞赛创新创业类一等奖等。

在读研究生12人（博士4人，硕士8人）。已毕业3名博士和14名硕士，3名博士分别入职西北农林科技大学、海南大学和中国水产科学研究院，8名硕士研究生继续攻读博士学位（厦门大学、中山大学、华东师范大学、中国海洋大学、西北农林科技大学），2名硕士研究生录取为选调生，1名硕士研究生录取为公务员，1名硕士研究生进入事业单位。研究生累计荣获国家奖学金8次、校长奖学金1次、陕西省优秀毕业生1次、校级优秀毕业生1次、校级优秀博士学位论文2次、校级优秀学术型硕士学位论文3次、校级优秀专业学位硕士学位论文3次、大学生创新创业大赛陕西省银奖、校级优秀研究生等。

6．主持科研项目

主持科研项目10余项，包括国家基金面上项目、国家基金青年基金、中国博士后基金特别资助、中国博士后基金面上项目、陕西省重点研发项目、陕西省自然科学基金面上项目和青年项目等。

[1] 国家自然科学基金-面上项目（32173011），2022-2025。

[2] 国家自然科学基金-青年基金（31602204），2017-2019。

[3] 中国博士后科学基金-特别资助（2016T90956），2016-2017。

[4] 中国博士后科学基金-面上项目一等资助（2015M580888），2015-2017。

[5] 陕西省重点研发一般项目-农业领域（2024NC-YBXM-095），2024-2025。

[6] 陕西省自然科学基础研究计划-面上项目（2019JM-035），2019-2020。

[7] 陕西省自然科学基础研究计划-青年人才项目（2016JQ3016），2016-2017。

[8] 陕西省博士后科学基金二等资助（2016BSHEDZZ114），2016-2017。

[9] 深圳万可森生物科技有限公司横向课题，2024-2025。

[10] 深圳万可森生物科技有限公司横向课题，2025-2026。

7．学术论文（通讯作者论文*）

以第一作者或通讯作者在《PLOS Pathogens》、《Journal of Virology》、《The Journal of Immunology》、《Cell Communication and Signaling》、《Journal of Nanobiotechnology》、《ACS Applied Materials & Interfaces》、《Water Biology and Security》、《Antiviral Research》、《Microbiology Spectrum》、《Vaccine》、《Vaccines》、《Aquaculture》和《Fish & Shellfish Immunology》等期刊发表SCI论文90余篇，2020年至今连续入选全球前2%顶尖科学家榜单（World’s Top 2%）。近年文章信息如下：

2025年

[1] Xu Fei-Fan, Zhao Zhao, Deng Zhu-Yang, Tang Jia-Lun, Zhu Bin*. Self-assembled nanoparticle vaccine comprised of multiple epitopes provides robust protective immunity against reoviruses in fish model. Cell Communication and Signaling. 2025, 23:389.

[2] Zhao Liang, Wei Xue-Feng, Xu Kun*, Zhao Zhao, Chen Guo, Wang Hou-Peng*, Zhu Bin*. Single-chain antibody gene therapy strategy based on high-throughput screening triggers sustained antiviral activity in the body. Journal of Virology. 2025, 99(1):e01497-24.

[3] Wei Xue-Feng, Zhao Liang, Zhao Zhao, Gong Yu-Ming, Zheng Yu-Ying, Cheng Gao-Feng, Wang Gao-Xue*, Zhu Bin*, Kong Wei-Guang*. Design of antibody structure-guided epitope vaccines in silico to induce potent immune responses against emerging viruses. Journal of Virology. 2025, https://doi.org/10.1128/jvi.00689-25.

[4] Wei Xue-Feng, Deng Zhu-Yang, Xu Fei-Fan, Tang Jia-Lun, Chen Le-Yang, Zhu Bin*. APC receptor TLR22a-targeted antigen structure optimization enhances immune protection against grass carp reovirus II. Water Biology and Security. https://doi.org/10.1016/j.watbs.2025.100505.

[5] Xia Jun-Yao, Jia Yi-Jun, Zhao Liang, Yang Zhi-Bang, Zhao Zhao, Zhu Bin*. Ferritin-based self-assembling nanovaccines induces durable and effective immune responses against LMBV in largemouth bass. Water Biology and Security. https://doi.org/10.1016/j.watbs.2025.100450.

[6] Deng Zhu-Yang, Li Yu-Ya, Liu Yong-Qi, Chen Le-Yang, Zhao Zhao*, Zhu Bin*. Evaluation of synthetic peptide vaccines based on phage display technology for Grass carp reovirus. Aquaculture. 2025, https://doi.org/10.1016/j.aquaculture.2025.743383.

[7] Sheng Jun-Jie, Wei Xue-Feng, Deng Zhu-Yang, Jiang Hai-Feng, Zhu Bin*. Platycodin D: A promising anti tilapia lake virus natural compound from Platycodon grandiflorus. Aquaculture. 2025, 595:741618.

[8] Xu Fei-Fan, Deng Zhu-Yang, Li Jing-Kai, Chen Le-Yang, Liu Yong-Qi, Jiang Hai-Feng, Zhu Bin*. Self-assembled nanoparticle vaccine based on the grass carp ferritin remarkably enhance the protective immune responses against GCRV type II infection. Aquaculture. 2025, 602:742349.

[9] Sheng Jun-Jie, Wei Xue-Feng, Liu Mao-Lin, Ren Xiao-Hang, Liu Ming-Zhu, Zhu Bin*. Evaluation of a tilapia epitopes vaccine against Streptococcus agalactiae based on phage display technology. Fish & Shellfish Immunology. 2025, 167:110896.

[10] Jiang Fu-Yi, Xia Jun-Yao, Jia Yi-Jun, Zhu Bin*. Multi-epitope microsphere vaccine modified immunological efficacy against LMBV in largemouth bass (Micropterus salmoides). Virology. 2025, 602:742349.

[11] Jia Yi-Jun, Zhao Zhao, Chen Le-Yang, Liu Yong-Qi, Zhu Bin*. Carbon nanotube-based drug delivery system increases drug content and promotes immune response in mandarin fish. Fishes. 2025, 10(3):92.

2024年

[12] Zhao Zhao, Zhao Liang, Wei Xue-Feng, Jia Yi-Jun, Zhu Bin*. Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus. PLOS Pathogens. 2024, 20(12):e1012744.

[13] Zheng Yu-Ying, Zhao Liang, Wei Xue-Feng, Sun Tian-Zi, Xu Fei-Fan, Wang Gao-Xue*, Zhu Bin*. Vaccine molecule design based on phage display and computational modeling against rhabdovirus. The Journal of Immunology. 2024, 212(4):551-562.

[14] Zhang Chen, Zhao Zhao, Jia Yi-Jun, Zhang Peng-Qi, Sun Yun, Zhou Yong-Can, Wang Gao-Xue*, Zhu Bin*. Rationally designed self-assembling nanovaccine elicit robust mucosal and systemic immunity against rhabdovirus. ACS Applied Materials & Interfaces. 2024, 16(1):228-244.

[15] Sun Tian-Zi, Zhang Peng-Qi, Zhang Chen, Jiang Hai-Feng, Zhu Bin*. Development and evaluation of self-assembling nanovaccine for immune protection against spring viremia of carp. Aquaculture. 2024, 593:741273.

[16] Xia Jun-Yao, Jia Yi-Jun, Zheng Yu-Ying, Jiang Fu-Yi, Zhu Bin*. Evaluation of epitope vaccine based on phage display technology for largemouth bass virus. Aquaculture. 2024, 580:740288.

[17] Zhao Liang, Wang Wei-Ze, Jiang Tian-Tian, Sun Tian-Zi, Liu Bo*, Zhu Bin*. Drug delivery system based on metal-organic framework improved 5-Fluorouracil against spring viraemia of carp virus. Antiviral Research. 2024, 226:105881.

[18] Zhao Zhao, Meng Qiang, Sun Tian-Zi, Zhu Bin*. Mannose modified targeted immersion vaccine delivery system improves protective immunity against Infectious spleen and kidney necrosis virus in mandarin fish (Siniperca chuatsi). Vaccine. 2024, 42(11):2886-2894.

[19] Xu Fei-Fan, Deng Zhu-Yang, Sheng Jun-Jie, Zhu Bin*. The HSP70 and IL-1β of Nile tilapia as molecular adjuvants can enhance the immune protection of DNA vaccine against Streptococcus agalactiae infection. Journal of Fish Diseases. 2024, 47(11):e14002.

2023年

[20] Gong Yu-Ming, Wei Xue-Feng, Zheng Yu-Ying, Li Yang, Yu Qing, Li Peng-Fei*, Zhu Bin*. Combining phage display technology with in silico-designed epitope vaccine to elicit robust antibody responses against emerging pathogen Tilapia Lake Virus. Journal of Virology. 2023, 97(4):e00050-23.

[21] Zheng Yu-Ying, Li Yang, Sun Tian-Zi, Wei Xue-Feng, Liu Ming-Zhu, Li Peng-Fei*, Wang Gao-Xue*, Zhu Bin*. Inulin acetate as a novel recombinant subunit vaccine carrier for immunization of tilapia against tilapia lake virus. Aquaculture. 2023, 571:739439.

[22] Wei Xue-Feng, Gong Yu-Ming, Xia Jun-Yao, Liu Ming-Zhu, Li Peng-Fei*, Wang Gao-Xue*, Zhu Bin*. Biomimetic nanovaccine based on erythrocyte membrane enhances immune response and protection against Tilapia Lake Virus. Virology. 2023, 580:41-49.

2022年

[23] Zhang Chen, Zhao Zhao, Zhang Peng-Qi, Guo Sheng, Zhu Bin*. TLR2-mediated mucosal immune priming boosts anti-rhabdoviral immunity in early vertebrates. Antiviral Research. 2022, 203:105346.

[24] Zhang Chen, Zhang Peng-Qi, Guo Sheng, Zhao Zhao, Wang Gao-Xue*, Zhu Bin*. Dual-targeting polymer nanoparticles efficiently deliver DNA vaccine and induce robust prophylactic immunity against spring viremia of carp virus infection. Microbiology Spectrum. 2022, 10(5):e0308522.

[25] Zhang Chen, Guo Sheng, Chen Guo, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Mucosal delivery of mannose functionalized biomimetic nanoparticles via the branchial route induces robust mucosal and systemic immune responses against fish viral disease. Aquaculture. 2022, 546:737329.

[26] Gong Yu-Ming, Wei Xue-Feng, Zhou Guo-Qing, Liu Ming-Zhu, Li Peng-Fei*, Zhu Bin*. Mannose functionalized biomimetic nanovaccine enhances immune responses against tilapia. Aquaculture. 2022, 560:738535.

[27] Jia Yi-Jun, Xia Jun-Yao, Jiang Fu-Yi, Li Yang, Chen Guo, Zhu Bin*. Antigenic epitope screening and functional modification of mannose enhance the efficacy of largemouth bass virus subunit vaccines. Journal of Fish Diseases. 2022, 45: 1635-1643.

[28] Xu Fei-Fan, Jiang Fu-Yi, Zhou Guo-Qing, Xia Jun-Yao, Yang Fei, Zhu Bin*. The recombinant subunit vaccine encapsulated by alginate-chitosan microsphere enhance the immune effect against Micropterus Salmoides rhabdovirus. Journal of Fish Diseases. 2022, 45: 1757-1765.

[29] Zhao Zhao, Li Yang, Chen Guo, Zhang Chen, Wang Gao-Xue*, Zhu Bin*. Protective immunity against infectious spleen and kidney necrosis virus induced by mannose modified subunit vaccine with carbon nanotubes in mandarin fish. Aquaculture Research. 2022, 53:2175-2184.

[30] Zhao Zhao, Jiang Fu-Yi, Zhou Guo-Qing, Duan Hui-Xin, Xia Jun-Yao, Zhu Bin*. Protective immunity against spring viremia of carp virus by mannose modified chitosan loaded DNA vaccine. Virus Research. 2022, 320:198896.

8．发明专利

[1] Zhu Bin. TiLV-2 protein or gene encoding TiLV-2 protein in preparation of subunit vaccine against Tilapia lake virus. Date of grant: 2022-6-3, Netherlands, Patent Number: 2028806.

[2] Zhu Bin, Zhang Chen, Guo Sheng. Dual-targeting DNA vaccine of spring viraemia of carp virus and a preparation method thereof. Date of grant: 2021-10-27, South African, Patent Number: 2021/05991.

[3] 朱斌，孙天姿，陈宙，柳永琪，杨志邦。一种抗LMBV的单链抗体及其在制备量子点荧光免疫层析试纸条中的应用，2025.10，中国，专利号：ZL202411457247.6。

[4] 朱斌，夏军尧，王文博，焦铁军，卢静，马瑞，孟强。一种大口黑鲈蛙虹彩病毒的多表位肽及其制备方法与应用。2024.11，中国，专利号：ZL202411059791.5

[5] 朱斌，王高学，张晨，赵昭。鱼类蛋白自组装纳米抗原及其制备的疫苗与应用，2024.06，中国，专利号：ZL202211434461.0。

[6] 王文博，朱斌，夏军尧，焦铁军，马瑞，孟强，卢静。抗大口黑鲈虹彩病毒的单链抗体蛋白及其筛选方法与应用，2024.08，中国，专利号：ZL202410756105.3。

[7] 王高学，朱斌，凌飞，郭孜饶，焦铁军. 一种鲈鱼弹状病毒亚单位疫苗及其制备方法，2021.11，中国，授权号ZL202111066165.5。

[8] 王高学，朱斌，凌飞，郭孜饶，焦铁军. 一种鲈鱼弹状病毒重组G2蛋白及其应用，2021.11，中国，授权号ZL202111066177.8。

[9] 王高学，朱斌，刘广路，凌飞. 碳纳米管载体免注射疫苗、制备方法及其在制备水产免疫苗种中的应用，2016.01，中国，授权号ZL201310482649.7.

[10] 王高学，赵昭，朱斌，凌飞，马瑞，龚宇明. 截短表达的鳜传染性脾肾坏死病毒主衣壳蛋白及其应用，2023.07，中国，授权号ZL202111449927.X.

9．联系方式

通讯地址：陕西杨凌西农路22号西北农林科技大学动物科技学院

联系电话：13572487467

E-mail：zhubin1227@126.com