朱斌

　　

　　

　　1．基本信息　　

　　朱斌，男，1985年12月生，湖北宜昌人，博士，副教授、博士生导师。2015年7月入选西北农林科技大学“青年英才计划”留校任教。现为中国水产学会鱼病专业委员会会员。

　　2．教育经历

　　2012.9-2015.6，西北农林科技大学水生生物学专业获博士学位；

　　2009.9-2012.6，西北农林科技大学水生生物学专业获硕士学位；

　　2005.9-2009.6，西北农林科技大学水产养殖学专业获学士学位。

　　3．工作经历

　　2015.7至今，西北农林科技大学动物科技学院任教。

　　4．研究方向

　　主要从事水产动物病害防控研究，具体研究内容包括：（1）水产纳米载药系统的开发应用；（2）水产疫苗的分子设计和开发应用；（3）水产疫苗免疫分子机制研究。

　　5．开设课程

　　承担本科生《水产动物免疫学》、《鱼类药理学》、《水产动物病害学》和研究生《水生动植物疾病诊治及防控》等课程教学任务。

　　6．学术成果

　　主要围绕水产动物新型疫苗的创制及其分子免疫作用机制开展研究，现已获批主持国家和省部级等科研项目10余项。目前发表SCI论文50余篇，累计影响因子超过200。以第一作者或通讯作者在《Nanotoxicology》、《Journal of Nanobiotechnology》、《Antiviral Research》、《Vaccine》、《Cellular Signalling》、《Fish & Shellfish Immunology》和《Science of The Total Environment》等期刊发表SCI论文37篇，总影响因子超过130，其中包括中科院大类1区论文13篇、2区论文13篇，TOP期刊论文26篇。获批国家发明专利2项。

　　6.1主持科研项目

　　（1）陕西省自然科学基础研究计划-面上项目（2019JM-035），碳纳米管载鲤春病毒血症病毒DNA疫苗系统靶向免疫作用研究，2019.1-2020.12。

　　（2）广东省水生经济动物良种繁育重点实验室开放基金，碳纳米管载鳜DNA疫苗系统免疫效果研究，2018.06-2019.12。

　　（3）西北农林科技大学青年英才培育计划“卓越新星”资助（2452018029）：水产动物纳米靶向抗病研究，2018.01-2020.12。

　　（4）西北农林科技大学动物科技学院“博领青年学者”项目资助，2018.01-2019.12。

　　（5）陕西省博士后科研配套资助项目：2017.06-2019.06。

　　（6）中央高校基本科研业务费（2452017078）：碳纳米管载鲤春病毒血症病毒疫苗系统靶向免疫作用研究，2017.01-2020.01。

　　（7）农业部渔用药物创制重点实验室开放课题（201602）：碳纳米管载鳜ISKNV疫苗系统研究，2017.01-2018.12。

　　（8）国家自然科学基金-青年基金（31602204）：碳纳米管载草鱼呼肠孤病毒DNA疫苗系统靶向免疫机制研究，2017.01-2019.12。

　　（9）陕西省自然科学基础研究计划-青年人才项目（2016JQ3016）：靶向甘露糖受体的草鱼出血病碳纳米管载体疫苗系统基础研究，2016.01-2017.12。

　　（10）陕西省博士后科学基金二等资助（2016BSHEDZZ114）：碳纳米管载嗜水气单胞菌疫苗系统靶向免疫作用机制研究，2016.03-2017.12。

　　（11）中国博士后科学基金特别资助（2016T90956）：碳纳米管载药系统靶向抗病毒和靶向免疫作用机制研究，2016.03-2017.12。

　　（12）西北农林科技大学优博论文获得者留校基金（A213021620）：2016.01- 2018.12。

　　（13）中国博士后科学基金面上资助金一等资助（2015M580888）：碳纳米管载药系统靶向抗草鱼呼肠孤病毒研究，2015.09-2017.07。

　　（14）西北农林科技大学“青年英才计划”（Z111021510）：碳纳米管载药靶向抗草鱼呼肠孤病毒研究，2015.09-2020.09。

　　6.2代表性学术论文（*通讯作者）

　　（1）Hu Yang, Chen Wei-Chao, Shen Yu-Feng, Zhu Bin*, Wang Gao-Xue*. Synthesis and antiviral activity of a new arctigenin derivative against IHNV in vitro and in vivo. Fish & Shellfish Immunology. 2019. (Accepted) (IF="3.298，Top期刊，中科院农林科学1区)

　　（2）Zhao Zhao, Zhang Chen, Jia Yi-Jun, Qiu De-Kui, Lin Qiang, Li Ning-Qiu, Huang Zhi-Bin, Fu Xiao-Zhe, Wang Gao-Xue*, Zhu Bin*. Immersion vaccination of Mandarin fish Siniperca chuatsi against infectious spleen and kidney necrosis virus with a SWCNTs-based subunit vaccine. Fish & Shellfish Immunology. 2019, 92:133-140. (IF="3.298，Top期刊，中科院农林科学1区)

　　（3）Shen Yu-Feng, Hu Yang, Zhu Bin*, Wang Gao-Xue*. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish. Virus Research. 2019, 268:38-44. (IF="2.736，中科院医学3区)

　　（4）Hu Yang, Chen Wei-Chao, Shen Yu-Feng, Zhu Bin*, Wang Gao-Xue*. Synthesis and antiviral activity of coumarin derivatives against infectious hematopoietic necrosis virus. Bioorganic & Medicinal Chemistry Letters. 2019, 29(14):1749-1755. (IF="2.448，中科院医学3区)

　　（5）Hu Yang, Liu Lei, Li Bo-Yang, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus. European Journal of Medicinal Chemistry. 2019, 163:183-194. (IF="4.833，Top期刊，中科院医学2区)

　　（6）Zhang Chen, Zhao Zhao, Li Jian, Song Kai-Ge, Hao Kai, Wang Jin, Wang Gao-Xue, Zhu Bin*. Bacterial ghost as delivery vehicles loaded with DNA vaccine induce significant and specific immune responses in common carp against spring viremia of carp virus. Aquaculture. 2019, 504:361-368. (IF="3.022，Top期刊，中科院农林科学2区)

　　（7）Huang Ai-Guo, Tu Xiao, Qi, Xiao-Zhou, Ling Fei, Zhu Bin*, Wang Gao-Xue*. Gardenia jasminoides Ellis inhibit white spot syndrome virus replication in red swamp crayfish Procambarus clarkii. Aquaculture. 2019, 504:239-247. (IF="3.022，Top期刊，中科院农林科学2区)

　　（8）Shen Yu-Feng, Hu Yang, Zhang Zhao, Liu Lei, Chen Cheng, Tu Xiao, Wang Gao-Xue*, Zhu Bin*. Saikosaponin D efficiently inhibits SVCV infection in vitro and in vivo. Aquaculture. 2019, 504:281-290. (IF="3.022，Top期刊，中科院农林科学2区)

　　（9）Hu Yang, Shen Yu-Feng, Li Bo-Yang, Wang Gao-Xue*, Zhu Bin*. Evaluation on the antiviral activity of ribavirin against infectious hematopoietic necrosis virus in epithelioma papulosum cyprini cells. Virus Research. 2019, 263:73-79. (IF="2.736，中科院医学3区)

　　（10）Zhu Song, Luo Fei, Li Jian, Zhu Bin*, Wang Gao-Xue*. Biocompatibility assessment of single-walled carbon nanotubes using Saccharomyces cerevisiae as a model organism. Journal of Nanobiotechnology. 2018, 16(1):44. (IF="5.345，Top期刊，中科院工程技术1区)

　　11）Zhang Chen, Li Lin-Han, Wang Jin, Zhao Zhao, Li Jian, Tu Xiao, Huang Ai-Guo, Wang Gao-Xue*, Zhu Bin*. Enhanced protective immunity against spring viremia of carp virus infection can be induced by recombinant subunit vaccine conjugated to single-walled carbon nanotubes. Vaccine. 2018, 36(42):6334-6344. (IF="3.269，Top期刊，中科院医学2区)

　　12）Chen Wei-Chao, Liu Lei, Shen Yu-Feng, Hu Yang, Ling Fei, Wang Gao-Xue*, Zhu Bin*. A new coumarin derivative plays a role in rhabdoviral clearance by interfering glycoprotein function during the early stage of viral infection. Cellular Signalling. 2018, 51:199-210. (IF="3.388，中科院生物2区)

　　13）Chen Wei-Chao, Hu Yang, Liu Lei, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Synthesis and in vitro activities evaluation of arctigenin derivatives against spring viraemia of carp virus. Fish & Shellfish Immunology. 2018, 82:17-26. (IF="3.298，Top期刊，中科院农林科学1区)

　　14）Shen Yu-Feng, Liu Lei, Feng Cheng-Zhang, Hu Yang, Chen Cheng, Wang Gao-Xue*, Zhu Bin*. Synthesis and antiviral activity of a new coumarin derivative against spring viraemia of carp virus. Fish & Shellfish Immunology. 2018, 81:57-66. (IF="3.298，Top期刊，中科院农林科学1区)

　　15）Zhang Chen, Zhao Zhao, Liu Gao-Yang, Li Jian, Wang Gao-Xue*, Zhu Bin*. Immune response and protective effect against spring viremia of carp virus induced by intramuscular vaccination with a SWCNTs-DNA vaccine encoding matrix protein. Fish & Shellfish Immunology. 2018, 79:256-264. (IF="3.298，Top期刊，中科院农林科学1区)

　　（16）Shan Li-Peng, Chen Xiao-Hui, Ling Fei, Zhu Bin*, Wang Gao-Xue*.Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection. Virus Research. 2018, 247:1-9. (IF="2.736，中科院医学3区)

　　（17）Chen Cheng, Shen Yu-Feng, Hu Yang, Liu Lei, Chen Wei-Chao, Wang Gao-Xue*, Zhu Bin*. Highly efficient inhibition of spring viraemia of carp virus replication in vitro mediated by bavachin, a major constituent of Psoralea corlifonia Lynn. Virus Research. 2018. 255:24-35. (IF="2.736，中科院医学3区)

　　（18）Zhu Bin*, Zhu Song, Li Jian, Wang Gao-Xue. The developmental toxicity, bioaccumulation and distribution of oxidized single walled carbon nanotubes in Artemia salina. Toxicology Research. 2018. 79:256-264. (IF="1.593，中科院环境科学与生态学3区)

　　（19）Zhu Song, Luo Fei, Chen Weichao, Zhu Bin*, Wang Gao-Xue*. Toxicity evaluation of graphene oxide on cysts and three larval stages of Artemia salina. Science of The Total Environment. 2017, 595:101-109. (IF="5.589，Top期刊，中科院环境科学与生态学2区)

　　（20）Liu Lei, Hu Yang, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Evaluation on antiviral activity of coumarin derivatives against spring viraemia of carp virus in epithelioma papulosum cyprini cells. Antiviral Research. 2017, 144:173-185. (IF="4.130，中科院医学2区)

　　（21）Hao Kai, Chen Xiao-Hui, Qi Xiao-Zhou, Yu Xiao-Bo, Du En-Qi, Ling Fei, Zhu Bin*, Wang Gao-Xue*. Protective immunity of grass carp induced by DNA vaccine encoding capsid protein gene (vp7) of grass carp reovirus using bacterial ghost as delivery vehicles. Fish & Shellfish Immunology. 2017, 64:414-425. (IF="3.298，Top期刊，中科院农林科学1区)

　　（22）Zhang Chen, Zhao Zhao, Zha Ji-Wei, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of a DNA vaccine against spring viremia of carp virus in common carp. Fish & Shellfish Immunology. 2017, 71:191-201. (IF="3.298，Top期刊，中科院农林科学1区)

　　（23）Liu Lei, Tu Xiao, Shen Yu-Feng, Chen Wei-Chao, Zhu Bin*, Wang Gao-Xue*. The replication of spring viraemia of carp virus can be regulated by reactive oxygen species and NF-κB pathway. Fish & Shellfish Immunology. 2017, 67:211-217. (IF="3.298，Top期刊，中科院农林科学1区)

　　（24）Zhu Song, Luo Fei, Zhu Bin*, Wang Gao-Xue*. Mitochondrial impairment and oxidative stress mediated apoptosis induced by α-Fe₂O₃ nanoparticles in Saccharomyces cerevisiae. Toxicology Research. 2017, 6:719-728. (IF="1.593，中科院环境科学与生态学3区)

　　（25）Zhu Song, Luo Fei, Zhu Bin*, Wang Gao-Xue*. Toxicological effects of graphene oxide on Saccharomyces cerevisiae. Toxicology Research. 2017, 6:535-543. (IF="1.593，中科院环境科学与生态学3区)

　　（26）Yu Xiao-Bo, Chen Xiao-Hui, Ling Fei, Hao Kai, Wang Gao-Xue*, Zhu Bin*. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Research. 2016, 131:156-165. (IF="4.130，中科院医学2区)

　　（27）Wang Yuan, Liu Guang-Lu, Li Dong-Liang, Ling Fei, Zhu Bin*, Wang Gao-Xue*. The protective immunity against grass carp reovirus in grass carp induced by a DNA vaccination using single-walled carbon nanotubes as delivery vehicles. Fish & Shellfish Immunology. 2015, 47:732-742. (IF="3.298，Top期刊，中科院农林科学1区)

　　（28）Zhu Bin, Liu Guang-Lu, Ling Fei, Song Lin-Sheng, Wang Gao-Xue*. Development toxicity of functionalized carbon nanotubes on rare minnow embryos and larvae. Nanotoxicology. 2015. 9(5):579-590. (IF="7.913，Top期刊，中科院医学1区)

　　（29）Zhu Bin, Liu Guang-Lu, Ling Fei, Wang Gao-Xue*. Carbon nanotube-based nanocarrier loaded with ribavirin against grass carp reovirus. Antiviral Research. 2015, 118:29-38. (IF="4.130，中科院医学2区)

　　（30）Zhu Bin, Liu Guang-Lu, Liu Lei, Ling Fei, Wang Gao-Xue*. Assessment of trifloxystrobin uptake kinetics, developmental toxicity and mRNA expression in rare minnow embryos. Chemosphere. 2015, 120:447-455. (IF="5.108，Top期刊，中科院环境科学与生态学2区)

　　（31）Zhu Bin, Liu Guang-Lu, Gong Yu-Xin, Ling Fei, Wang Gao-Xue*. Protective immunity of grass carp immunized with DNA vaccine encoding the vp7 gene of grass carp reovirus using carbon nanotubes as a carrier molecule. Fish & Shellfish Immunology. 2015, 42(2):325-334. (IF="3.298，Top期刊，中科院农林科学1区)

　　（32）Zhu Bin, Liu Guang-Lu, Gong Yu-Xin, Ling Fei, Song Lin-Sheng, Wang Gao-Xue*. Single-walled carbon nanotubes as candidate recombinant subunit vaccine carrier for immunization of grass carp against grass carp reovirus. Fish & Shellfish Immunology. 2014, 41(2):279-293. (IF="3.298，Top期刊，中科院农林科学1区)

　　（33）Zhu Bin, Gong Yu-Xin, Liu Lei, Li Dong-Liang, Wang Yuan, Ling Fei, Wang Gao-Xue*. Toxic effects of triazophos on rare minnow (Gobiocypris rarus) embryos and larvae. Chemosphere. 2014, 108:46-54. (IF="5.108，Top期刊，中科院环境科学与生态学2区)

　　（34）Zhu Bin, Liu Lei, Li Dong-Liang, Ling Fei, Wang Gao-Xue*. Developmental toxicity in rare minnow (Gobiocypris rarus) embryos exposed to Cu, Zn and Cd. Ecotoxicology and Environmental Safety. 2014, 104:269-277. (IF="4.527，中科院环境科学与生态学3区)

　　（35）Zhu Bin, Liu Lei, Gong Yu-Xin, Ling Fei, Wang Gao-Xue*. Triazole-induced toxicity in developing rare minnow (Gobiocypris rarus) embryos. Environmental Science and Pollution Research. 2014, 21(23): 13625-13635. (IF="2.914，中科院环境科学与生态学3区)

　　（36）Zhu Bin, Liu Tian-Qiang, Hu Xue-Gang, Wang Gao-Xue*. Developmental toxicity of 3,4-dichloroaniline on rare minnow (Gobiocypris rarus) embryos and larvae. Chemosphere. 2013, 90(3):1132-1139. (IF="5.108，Top期刊，中科院环境科学与生态学2区)

　　（37）Zhu Bin, Wu Zong-Fan, Li Jun, Wang Gao-Xue*. Single and joint action toxicity of heavy metals on early developmental stages of Chinese rare minnow (Gobiocypris rarus). Ecotoxicology and Environmental Safety. 2011, 74(8): 2193- 2202. (IF="4.527，中科院环境科学与生态学3区)

　　6.3发明专利

　　（1）王高学, 朱斌, 刘广路, 凌飞. 碳纳米管载体免注射疫苗、制备方法及其在制备水产免疫苗种中的应用, 2016.01, 中国, 授权号ZL. 201310482649.7.

　　（2）王高学, 刘广路, 朱斌, 凌飞. 碳纳米管载抗病毒药物复合物、制备方法及其在水产养殖无病毒携带苗生产中的应用, 2016.01, 中国, 授权号ZL. 201310482759.3.

　　7．联系方式

　　通讯地址：陕西杨凌西农路22号 西北农林科技大学动物科技学院

　　邮编：712100

　　Email：zhubin@nwsuaf.edu.cn, zhubin1227@126.com