Chao Sun

　　 　　

　　Chao Sun

　　ADDRESS:

　　College of Animal Science and TechnologyNorthwest A&F University　No.3 Taicheng Road　Yangling, Shaanxi, 712100, China

　　Email: sunchao2775@163.com

　　EDUCATION:

　　Ph.D. in Animal genetic breeding and reproduction.Northwest A&F University, Yangling, 2001.12

　　M. S.in Animal genetic breeding and reproduction. Northwest A&F University, Yangling, 1998.06

　　B. S. in nimal Science. Northwest A&F University, Yangling,1993.06

　　PROFESSIONAL EXPERIENCE:

　　Post-doctor, 2009/03-2011/02

　　Department of cellular and Molecular Physiology

　　Pennsylvania State University College of Medicine

　　Professor, 2008/12-present,

　　College of Animal Science and Technology, Northwest A&F University

　　Associate professor, 2003/01- 2008/11,

　　College of Animal Science and Technology, Northwest A&F University

　　Lecturer,1999/01 - 2002/12,

　　College of Animal Science and Technology, Northwest A&F University

　　Assistant, 1993/07 - 1998/12,

　　College of Animal Science and Technology, Northwest A&F University

　　PUBLICATIONS:

　　１.Wei, D., Tian, X., Zhu, L., Wang, H., & Sun, C. （2023）。 USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1. Cell Death & Disease, 14（8）， 566.2.Yang, H., Li, C., Che, M., Li, Y., Feng, R., & Sun, C. （2023）。 Gut microbiota mediates the anti-obesity effect of intermittent fasting by inhibiting intestinal lipid absorption. The Journal of Nutritional Biochemistry, 116, 109318.

　　3.Li, Y., Liang, J., Tian, X., Chen, Q., Zhu, L., Wang, H., … & Sun, C. （2023）。 Intermittent fasting promotes adipocyte mitochondrial fusion through Sirt3-mediated deacetylation of Mdh2. British Journal of Nutrition, 1-14.

　　4.Li, C., Chen, Q., Liu, Y., Sun, Z., Shen, Z., Li, S., … & Sun, C. （2023）。 Methionine enkephalin promotes white fat browning through cAMP/PKA pathway. Life Sciences, 312, 121189.

　　5.Wei, D., Li, Y., Che, M., Li, C., Wu, Q., & Sun, C. （2022）。 Melatonin relieves hepatic lipid dysmetabolism caused by aging via modifying the secondary bile acid pattern of gut microbes. Cellular and Molecular Life Sciences, 79（10）， 527.

　　6.Pan, M., Sun, Q., Li, C., Tai, R., Shi, X. E., & Sun, C. （2022）。 Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2/STAT3 signaling pathway in mice. Biochemistry and Cell Biology, 100（4）， 325-337.

　　7.Liu, Y., Li, Y., Liang, J., Sun, Z., Wu, Q., Liu, Y., & Sun, C. （2022）。 Leptin: an entry point for the treatment of peripheral tissue fibrosis and related diseases. International Immunopharmacology, 106, 108608.

　　8.Chen, Y., Che, M., Li, C., Li, Y., Zhang, T., Li, X., & Sun, C. （2022）。 PP1A prevents ROS‐induced pyroptosis by inhibiting MAPK/caspase‐3 in mouse adipose tissue. The FEBS Journal, 289（13）， 3839-3853.

　　9.Wu, Q., Yang, H., Tai, R., Li, C., Xia, T., Liu, Y., & Sun, C. （2022）。 Lnc‐hipk1 inhibits mouse adipocyte apoptosis as a sponge of miR‐497. BioFactors, 48（1）， 135-147.

　　10.Yang, H., Li, C., Li, Y., Tai, R., & Sun, C. （2021）。 Adipose-derived stem cells and obesity: The spear and shield relationship. Genes & Diseases.

　　11.Rong, B., Wu, Q., Reiter, R. J., & Sun, C. （2021）。 The mechanism of oral melatonin ameliorates intestinal and adipose lipid dysmetabolism through reducing Escherichia Coli-derived lipopolysaccharide. Cellular and Molecular Gastroenterology and Hepatology, 12（5）， 1643-1667.

　　12.Rong, B., Wu, Q., Saeed, M., & Sun, C. （2021）。 Gut microbiota—A positive contributor in the process of intermittent fasting-mediated obesity control. Animal Nutrition, 7（4）， 1283-1295.

　　13.Shen, Z., Liu, P., Sun, Q., Li, Y., Acharya, R., Li, X., & Sun, C. （2021）。 FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes. Apoptosis, 26（7-8）， 474-487.

　　14.Liu, Y., Yang, H., Liu, X., Gu, H., Li, Y., & Sun, C. （2021）。 Protein acetylation: a novel modus of obesity regulation. Journal of Molecular Medicine, 99（9）， 1221-1235.

　　15.Gu, H., Yang, K., Shen, Z., Jia, K., Liu, P., Pan, M., & Sun, C. （2021）。 ER stress—induced adipocytes secrete-aldo-keto reductase 1B7—containing exosomes that cause nonalcoholic steatohepatitis in mice. Free Radical Biology and Medicine, 163, 220-233.

　　16.Yang, H., Chen, L., Sun, Q., Yao, F., Muhammad, S., & Sun, C. （2021）。 The role of HDAC11 in obesity‐related metabolic disorders: A critical review. Journal of Cellular Physiology, 236（8）， 5582-5591.

　　17.Zhang, T., Chen, Y., Cai, J., Pan, M., Sun, Q., Zhang, J., & Sun, C. （2020）。 SOCS2 inhibits mitochondrial fatty acid oxidation via suppressing LepR/JAK2/AMPK signaling pathway in mouse adipocytes. Oxidative Medicine and Cellular Longevity, 2020.

　　18.Xia, T., Shen, Z., Cai, J., Pan, M., & Sun, C. （2020）。 ColXV aggravates adipocyte apoptosis by facilitating abnormal extracellular matrix remodeling in mice. International Journal of Molecular Sciences, 21（3）， 959.

　　19.Yang, K., Cai, J., Pan, M., Sun, Q., & Sun, C. （2020）。 Mark4 inhibited the browning of white adipose tissue by promoting adipocytes autophagy in mice. International Journal of Molecular Sciences, 21（8）， 2752.

　　20.Yang, H., Yang, K., Gu, H., & Sun, C. （2020）。 Dynamic post‐translational modifications in obesity. Journal of Cellular and Molecular Medicine, 24（3）， 2384.

　　21.Saeed, M., Khan, M. S., Kamboh, A. A., Alagawany, M., Khafaga, A. F., Noreldin, A. E., … & Chao, S. （2020）。 L-theanine: an astounding sui generis amino acid in poultry nutrition. Poultry science, 99（11）， 5625-5636.

　　22.Saeed, M., Naveed, M., BiBi, J., Ali Kamboh, A., Phil, L., & Chao, S. （2019）。 Potential nutraceutical and food additive properties and risks of coffee: A comprehensive overview. Critical reviews in food science and nutrition, 59（20）， 3293-3319.

　　23.Rong, B., Feng, R., Liu, C., Wu, Q., & Sun, C. （2019）。 Reduced delivery of epididymal adipocyte‐derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice. Journal of Pineal Research, 66（4）， e12561.

　　24.Zhang, Z., Zhang, T., Feng, R., Huang, H., Xia, T., & Sun, C. （2019）。 circARF3 alleviates mitophagy-mediated inflammation by targeting miR-103/TRAF3 in mouse adipose tissue.Molecular Therapy-Nucleic Acids,14, 192-203.

　　25.Bohan, R., Tianyu, X., Tiantian, Z., Ruonan, F., Hongtao, H., Qiong, W., & Chao, S. （2019）。 Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism.The journal of nutritional biochemistry,64, 206-217.

　　26.Zhang, T., Zhang, Z., Xia, T., Liu, C., & Sun, C. （2019）。 circNrxn2 promoted WAT browning via sponging miR-103 to relieve its inhibition of FGF10 in HFD mice.Molecular Therapy-Nucleic Acids,17, 551-562.

　　27.Cao, W., Zhang, T., Feng, R., Xia, T., Huang, H., Liu, C., & Sun, C. （2019）。 Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue.Journal of cellular and molecular medicine,23（10）， 7029-7042.

　　28.Saeed, M., Yatao, X., Tiantian, Z., Qian, R., & Chao, S. （2019）。 16S ribosomal RNA sequencing reveals a modulation of intestinal microbiome and immune response by dietary L-theanine supplementation in broiler chickens.Poultry science,98（2）， 842-854.

　　29.Song, Z., Wang, Y., Zhang, F., Yao, F., & Sun, C. （2019）。 Calcium signaling pathways: key pathways in the regulation of obesity.International Journal of Molecular Sciences,20（11）， 2768.

　　30.Liu, Z., Gan, L., Zhang, T., Ren, Q., & Sun, C. （2018）。 Melatonin alleviates adipose inflammation through elevating α‐ketoglutarate and diverting adipose‐derived exosomes to macrophages in mice. Journal of pineal research, 64（1）， e12455.

　　31.Gan, L., Liu, Z., & Sun, C. （2018）。 Obesity linking to hepatocellular carcinoma: a global view. Biochimica et Biophysica Acta （BBA）-Reviews on Cancer, 1869（2）， 97-102.

　　32.Cao, W., Huang, H., Xia, T., Liu, C., Muhammad, S., & Sun, C. （2018）。 Homeobox a5 promotes white adipose tissue browning through inhibition of the tenascin C/toll-like receptor 4/nuclear factor kappa B inflammatory signaling in mice.Frontiers in Immunology,9, 647.

　　33.Zhang, Z., Wu, S., Muhammad, S., Ren, Q., & Sun, C. （2018）。 miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/β-catenin/ATF6 pathway in preadipocytes.Journal of lipid research,59（5）， 843-853.

　　34.Saeed, M., Yatao, X., Hassan, F. U., Arain, M. A., Abd El-Hack, M. E., Noreldin, A. E., & Sun, C. （2018）。 Influence of graded levels of l-theanine dietary supplementation on growth performance, carcass traits, meat quality, organs histomorphometry, blood chemistry and immune response of broiler chickens.International Journal of Molecular Sciences,19（2）， 462.

　　35.Gan, L., Liu, Z., Feng, F., Wu, T., Luo, D., Hu, C., & Sun, C. （2018）。 Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice.International Journal of Obesity,42（2）， 252-259.

　　36.Li, M., Beauchemin, H., Popovic, N., Peterson, A., d’Hennezel, E., Piccirillo, C. A., … & Polychronakos, C. （2017）。 The common, autoimmunity-predisposing 620Arg> Trp variant of PTPN22 modulates macrophage function and morphology. Journal of autoimmunity, 79, 74-83.

　　37.Liu, Z., Gan, L., Xu, Y., Luo, D., Ren, Q., Wu, S., & Sun, C. （2017）。 Melatonin alleviates inflammasome‐induced pyroptosis through inhibiting NF‐κB/GSDMD signal in mice adipose tissue. Journal of Pineal Research, 63（1）， e12414.

　　38.Liu, Z., Gan, L., Luo, D., & Sun, C. （2017）。 Melatonin promotes circadian rhythm‐induced proliferation through C lock/histone deacetylase 3/c‐M yc interaction in mouse adipose tissue. Journal of pineal research, 62（4）， e12383.

　　39.Saeed, M., Naveed, M., Arif, M., Kakar, M. U., Manzoor, R., Abd El-Hack, M. E., … & Sun, C. （2017）。 Green tea （Camellia sinensis） and l-theanine: Medicinal values and beneficial applications in humans—A comprehensive review. Biomedicine & Pharmacotherapy, 95, 1260-1275.

　　40.Liu, Z., Gan, L., Wu, T., Feng, F., Luo, D., Gu, H., … & Sun, C. （2016）。 Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell death & disease, 7（11）， e2487-e2487.

　　PROJECTS:

　　1.Regulatory network and multi-gene interaction mechanism of high-yield, high-quality and efficient traits in pigs, "14th Five-Year Plan" national key research and development plan,2021.01-2026.12, 1.2 million.（Sub-project leader）

　　2.R&D and application of composite microecological preparations to replace antibiotic additives, R&D and Transformation Plan of Qinghai Province, 2022.01-2025.12, 600,000.

　　3.Research and practice of low-carbon healthy breeding and efficient nutrient utilization technology of pigs, Shaanxi Province2021Annual key R&D plan,2021.01-2022.12, 100,000.

　　4.Molecular mechanism of Hoxa5 promoting white fat browning in pigs through adipose tissue intrinsic lymphocytes, National Natural Science Foundation of China,2019.01-2021.12, 490,000.

　　5.Molecular regulation of intramuscular fat formation in pigs and innovative team for breeding of new varieties, Shaanxi Province Key Science and Technology Innovation Team Building Project（2017KCT-24），2017/01-2019/12, 1 million

　　6.Molecular mechanisms of Leptin and related factors regulating pig fat development, National Program on Key Basic Research Project （973 Program）（2015CB943102），2016/01-2019/12, 4.5 million

　　7.Collagen XV regulates the mechanism of action of porcine white fat browning through the "Ca2+-endoplasmic reticulum" axis, National Natural Science Foundation of China（31572365），2016/01-2019/12, 768,000.

　　8.Cloning and functional verification of the key gene bambi for porcine fat deposition, Major special project of the Ministry of Agriculture on transgenetics,2014/01-2016/12, 1.7 million.

　　9.αMSH regulates the molecular mechanism of porcine fat deposition and Leptin and Foxc2 secretion through PKA and ERK signaling pathways，National Natural Science Foundation of China（31172185），2014/01-2016/12, 580,000.

　　10.Molecular mechanism of SOCS-2 in GH signaling pathway regulation of porcine fat metabolism and its relationship with SOCS-3, National Natural Science Foundation of China,2009.01-2011.12, 380,000.

　　AWARDS:

　　SCIENTIFIC RESEARCH

　　1.Leptin regulates the molecular mechanism of adipocyte development and metabolism, Wu Changxin Animal Genetics and Breeding Scientific and Technological Achievement Award,2015, ranked 1;

　　2.Research on Livestock and Poultry Genetic Resources of Important Places in Five Provinces and Regions in Northwest China, Shaanxi Provincial People's Government, Second Prize of Science and Technology of Shaanxi Province, 2012, ranked 3;

　　3.Research on Fatty Deposition of Pigs and Its Regulatory Mechanism, People's Government of Shaanxi Province, Third Prize of Science and Technology of Shaanxi Province, 2016, Rank 4;

　　PERSONALREWARD

　　1.Special Prize for Teaching Achievement of Shaanxi Province, People's Government of Shaanxi Province, 2020, ranked 2;

　　2.First Prize of Shaanxi Province Teaching Achievement, Shaanxi Provincial People's Government, 2020, ranked 8;

　　3.Shaanxi Provincial First-class Course （Person in Charge）， Shaanxi Provincial Department of Education, 2019, Rank 1;

　　4.National Baosteel Outstanding Teacher Award, Baosteel Education Foundation, 2017, ranked 1;

　　5.Excellent Teaching Team of Shaanxi Province （Person in Charge）， Department of Education of Shaanxi Province, 2015, ranked 1;

　　6.Selected as "New Century Excellent Talent" by the Ministry of Education, Ministry of Education, 2007, ranked 1.