Bin Zhu

　　 　　

1. Basic Information

Bin Zhu, Ph.D.

Professor ofAquatic Science

Supervisor of Doctoral/Master's Candidates

Email: zhubin1227@126.com

Address:College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100

2. Educational Experience

2005.09-2009.06,Northwest A&F University, B.S., Aquaculture.

2009.09-2012.06, Northwest A&F University, M. S., Aquaculture.

2012.09-2015.06, Northwest A&F University, Ph. D., Hydrobiology.

3. Work Experience

2015.06-2015.08, Lecturer at College of Animal Science and Technology, Northwest A&F University.

2015.09-2021.12, Associate professor at College of Animal Science and Technology, Northwest A&F University.

2022.01-present, Professor at College of Animal Science and Technology, Northwest A&F University.

4. Research Interests

(1) Aquatic vaccine design and molecular immune mechanism.

(2) Development and application of aquatic nano drug delivery system.

(3) Antibody diagnosis and targeted therapy of aquatic pathogens.

5. Teaching Interests

Undergraduate course, Aquatic Animal Immunology.

Undergraduate course, Aquatic Animal Diseases.

Graduate course, Research Progress in Aquatic Animal Diseases.

6. Research Funding

(1) National Natural Science Foundation of China,32173011,2022-2025.

(2) National Natural Science Foundation of China,31602204,2017-2019.

(3) Natural Science Basic Research Program of Shaanxi Province,2019JM-035,2019-2020.

(4) Natural Science Basic Research Program of Shaanxi Province,2016JQ3016,2016-2017.

7. Publications (Since 2020, # co-first author, *corresponding author)

(1)Gong Yu-Ming#, Wei Xue-Feng#, Zheng Yu-Ying, Li Yang, Yu Qing, Li Peng-Fei*, Zhu Bin*. Combining phage display technology with in silico-designed epitope vaccine to elicit robust antibody responses against emerging pathogen Tilapia Lake Virus. Journal of Virology. 2023, 97(4):e00050-23.

(2)Zheng Yu-Ying#, Li Yang#, Sun Tian-Zi, Wei Xue-Feng, Liu Ming-Zhu, Li Peng-Fei*, Wang Gao-Xue*, Zhu Bin*. Inulin acetate as a novel recombinant subunit vaccine carrier for immunization of tilapia against tilapia lake virus. Aquaculture. 2023, 571:739439.

(3)Wei Xue-Feng, Gong Yu-Ming, Xia Jun-Yao, Liu Ming-Zhu, Li Peng-Fei*, Wang Gao-Xue*, Zhu Bin*. Biomimetic nanovaccine based on erythrocyte membrane enhances immune response and protection against Tilapia Lake Virus. Virology. 2023, 580:41-49.

(4)Zhang Chen, Zhao Zhao, Zhang Peng-Qi, Guo Sheng, Zhu Bin*. TLR2-mediated mucosal immune priming boosts anti-rhabdoviral immunity in early vertebrates. Antiviral Research. 2022, 203:105346.

(5)Zhang Chen, Zhang Peng-Qi, Guo Sheng, Zhao Zhao, Wang Gao-Xue*, Zhu Bin*. Dual-targeting polymer nanoparticles efficiently deliver DNA vaccine and induce robust prophylactic immunity against spring viremia of carp virus infection. Microbiology Spectrum. 2022, 10(5):e0308522.

(6)Zhang Chen, Guo Sheng, Chen Guo, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Mucosal delivery of mannose functionalized biomimetic nanoparticles via the branchial route induces robust mucosal and systemic immune responses against fish viral disease. Aquaculture. 2022, 546:737329.

(7)Gong Yu-Ming, Wei Xue-Feng, Zhou Guo-Qing, Liu Ming-Zhu, Li Peng-Fei*, Zhu Bin*. Mannose functionalized biomimetic nanovaccine enhances immune responses against tilapia. Aquaculture. 2022, 560:738535.

(8)Zhao Zhao#, Li Yang#, Chen Guo, Zhang Chen, Wang Gao-Xue*, Zhu Bin*. Protective immunity against infectious spleen and kidney necrosis virus induced by mannose modified subunit vaccine with carbon nanotubes in mandarin fish. Aquaculture Research. 2022, 53:2175-2184.

(9)Jia Yi-Jun, Xia Jun-Yao, Jiang Fu-Yi, Li Yang, Chen Guo, Zhu Bin*. Antigenic epitope screening and functional modification of mannose enhance the efficacy of largemouth bass virus subunit vaccines. Journal of Fish Diseases. 2022, 45: 1635-1643.

(10)XuFei-Fan, Jiang Fu-Yi, Zhou Guo-Qing, Xia Jun-Yao, Yang Fei, Zhu Bin*. The recombinant subunit vaccine encapsulated by alginate-chitosan microsphere enhance the immune effect againstMicropterusSalmoidesrhabdovirus. Journal of Fish Diseases. 2022, 45: 1757-1765.

(11)Zhao Zhao, Jiang Fu-Yi, Zhou Guo-Qing, DuanHui-Xin, Xia Jun-Yao, Zhu Bin*. Protective immunity against spring viremia of carp virus by mannose modified chitosan loaded DNA vaccine. Virus Research. 2022, 320:198896.

(12)Zhao Zhao, Ma Rui, GuoZi-Rao, Zhang Chen, Xiong Yan, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as drug carrier loaded with moroxydine hydrochloride against infectious spleen and kidney necrosis virus in mandarin fish. Aquaculture. 2021, 536:736469.

(13)Qiu De-Kui, Jia Yi-Jun, Gong Yu-Ming, Zheng Yu-Ying, Wang Gao-Xue, Zhu Bin*. Optimizing the immunization procedure of single-walled carbon nanotubes based vaccine against grass carp reovirus for grass carp. Aquaculture. 2021, 533:736152.

(14)Qiu De-Kui, Xiong Yan, Gong Yu-Ming, Zheng Yu-Ying, Ma Rui, Zhang Chen, Wang Gao-Xue, Zhu Bin*. Dominant antigen of Grass Carp Reovirus and immunity assessment with DNA vaccine for grass carp. Aquaculture. 2021, 530:735948.

(15)Zheng Yu-Ying, Qiu De-Kui, GuoZi-Rao, Gong Yu-Ming, Wang Gao-Xue*, Zhu Bin*. Evaluation of SWCNTs-loaded DNA vaccine encoding predominant antigen epitope VP4-3 against type II GCRV. Aquaculture. 2021, 534:736197.

(16)Zheng Yu-Ying#, Zhang Chen#, Li Yang, Zhang Peng-Qi, Chen Guo, Wang Gao-Xue, Zhu Bin*. Immersion immunization of common carp with bacterial ghost-based DNA vaccine induces prophylactic protective immunity against spring viremia of carp virus. Journal of Fish Diseases. 2021, 44(12): 2021-2029.

(17)Gong Yu-Ming#, Zhang Chen#, Li Yang, Chen Guo, Wang Gao-Xue, Zhu Bin*. Optimization of immunization procedure for SWCNTs-based subunit vaccine with mannose modification against spring viremia of carp virus in common carp. Journal of Fish Diseases. 2021, 44(12): 1925-1936.

(18)DuanHui-Xin#, Zhao Zhao#, Jin Ying-Jie, Wang Zi-Long, Deng Jie-Fang, He Jie, Zhu Bin*. PEG-modified subunit vaccine encoding dominant epitope to enhance immune response against spring viraemia of carp virus. Journal of Fish Diseases. 2021, 44(10):1587-1594.

(19)Liu Gao-Yang, Li Jian, Zhang Zhong-Yu, Liu Jing-Yao, Zhang Chen, Zhu Bin*, Wang Gao-Xue*. An immersion subunit vaccine loaded by single-walled carbon nanotube protects pearl gentian grouper from viral nervous necrosis virus. Aquaculture. 2021, 541:736813.

(20)Zhang Chen, Wang Gao-Xue, Zhu Bin*. Application of antigen presenting cell-targeted nanovaccine delivery system in rhabdovirus disease prophylactics using fish as a model organism. Journal of Nanobiotechnology. 2020, 18(1):24.

(21)Zhang Chen, Zhang Peng-Qi, Guo Sheng, Chen Guo, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Application of biomimetic cell-derived nanoparticles with mannose modification as a novel vaccine delivery platform against teleost fish viral disease. ACS Biomaterials Science & Engineering. 2020, 6(12):6770-6777.

(22)Zhao Zhao, Xiong Yan, Zhang Chen, Jia Yi-Jun, Qiu De-Kui, Wang Gao-Xue*, Zhu Bin*. Optimization of the efficacy of a SWCNTs-based subunit vaccine against infectious spleen and kidney necrosis virus in mandarin fish. Fish & Shellfish Immunology. 2020, 106:190-196.

(23)Liu Gao-Yang#, Wang Er-Long#, Qu Xiang-Yu, Yang Ke-Chen, Zhang Zhong-Yu, Liu Jing-Yao, Zhang Chen, Zhu Bin*, Wang Gao-Xue*. Single-walled carbon nanotubes enhance the immune protective effect of a bath subunit vaccine for pearl gentian grouper against Iridovirus of Taiwan. Fish & Shellfish Immunology. 2020.106:510-517.

(24)Zhang Chen, Guo Sheng, Zhao Zhao, GuoZi-Rao, Ma Rui, Wang Gao-Xue, Zhu Bin*. Surface display of spring viremia of carp virus glycoprotein on Lactococcuslactis and its protection efficacy in common carp (Cyprinuscarpio L.). Fish & Shellfish Immunology. 2020, 104:262-268.

(25)Zhao Zhao, Zhang Chen, Jia Yi-Jun, Wang Gao-Xue*, Zhu Bin*.In vivo efficacy of ganciclovir by using single-walled carbon nanotubes as a drug carrier against infectious spleen and kidney necrosis virus in mandarin fish. Aquaculture. 2020, 526:735434.

(26)Huang Ai-Guo, Tan Xiao-Ping, Cui Hai-Bo, Qi Xiao-Zhou, Zhu Bin*, Wang Gao-Xue*. Antiviral activity of geniposidic acid against white spot syndrome virus replication in red swamp crayfish Procambarus clarkia. Aquaculture. 2020, 528:735533.

(27)Jia Yi-Jun, GuoZi-Rao, Ma Rui, Qiu De-Kui, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Immune efficacy of carbon nanotubes recombinant subunit vaccine against largemouth bass ulcerative syndrome virus. Fish & Shellfish Immunology. 2020, 100:317-323.

(28)GuoZi-Rao, Zhao Zhao, Zhang Chen, Jia Yi-Jun, Qiu De-Kui, Zhu Bin*, Wang Gao-Xue*. Carbon nanotubes-loaded subunit vaccine can increase protective immunity against rhabdovirus infections of largemouth bass (MicropterusSalmoides). Fish & Shellfish Immunology. 2020, 99:548-554.

(29)Zhao Zhao, Zhang Chen, Lin Qiang, Li Ning-qiu, Huang Zhi-Bin, Zhao Mi, Fu Xiao-Zhe*, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of an immersion DNA vaccine against infectious spleen and kidney necrosis virus in mandarin fish. Fish & Shellfish Immunology. 2020, 97:432-439.

(30)Zhang Zhong-Yu, Liu Gao-Yang, Ma Rui, Qi Xiao-Zhou, Wang Gao-Xue, Zhu Bin*, Ling Fei*. The immunoprotective effect of whole-cell lysed inactivated vaccine with SWCNT as a carrier against Aeromonashydrophila infection in grass carp. Fish & Shellfish Immunology. 2020, 97:336-343.

(31)Qiu De-Kui, Zhao Zhao, Ma Rui, Guo Zi-Rao, Jia Yi-Jun, Zhang Chen, Wang Gao-Xue, Zhu Bin*. Antigen epitope screening of grass carp reovirus and its protectively immunity assessment for grass carp. Aquaculture. 2020, 515:734550.

(32)Zhu Bin#*, Zhang Chen#, Zhao Zhao, Wang Gao-Xue. Targeted delivery of mannosylated nanoparticles improve prophylactic efficacy of immersion vaccine against fish viral disease. Vaccines. 2020, 8(1):87.

(33)Jia Yi-Jun, GuoZi-Rao, Ma Rui, Qiu De-Kui, Wang Gao-Xue, Zhu Bin*. Protective immunity of largemouth bass immunized with immersed DNA vaccine against largemouth bass ulcerative syndrome virus. Fish & Shellfish Immunology. 2020, 107:269-276.